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NK cells are not required for spontaneous autoimmune diabetes in NOD mice.

NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute induced disease models of diabetes. Yet, the role of... Full description

Journal Title: PloS one 2012, Vol.7(4), p.e36011
Main Author: Beilke, Joshua N
Other Authors: Meagher, Craig T , Hosiawa, Karoline , Champsaur, Marine , Bluestone, Jeffrey A , Lanier, Lewis L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0036011
Link: http://search.proquest.com/docview/1011192293/?pq-origsite=primo
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recordid: proquest1011192293
title: NK cells are not required for spontaneous autoimmune diabetes in NOD mice.
format: Article
creator:
  • Beilke, Joshua N
  • Meagher, Craig T
  • Hosiawa, Karoline
  • Champsaur, Marine
  • Bluestone, Jeffrey A
  • Lanier, Lewis L
subjects:
  • Animals–Immunology
  • Cell Differentiation–Metabolism
  • Cell Membrane–Metabolism
  • Cell Proliferation–Immunology
  • Cytokines–Immunology
  • Cytotoxicity, Immunologic–Immunology
  • Dendritic Cells–Metabolism
  • Diabetes Mellitus, Type 1–Pathology
  • Disease Progression–Immunology
  • Killer Cells, Natural–Pathology
  • Liver–Immunology
  • Lymphocyte Activation–Immunology
  • Mice–Pathology
  • Mice, Inbred Nod–Pathology
  • Pancreas–Pathology
  • Phenotype–Pathology
  • Cytokines
ispartof: PloS one, 2012, Vol.7(4), p.e36011
description: NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute induced disease models of diabetes. Yet, the role of NK cells in spontaneous diabetes has not been directly addressed. Here, we used the NOD.NK1.1 congenic mouse model to examine the role of NK cells in spontaneous diabetes. Significant numbers of NK cells were only seen in the pancreas of mice with disease. Pancreatic NK cells displayed an activated surface phenotype and proliferated more than NK cells from other tissues in the diseased mice. Nonetheless, depletion of NK cells had no effect on dendritic cell maturation or T cell proliferation. In spontaneous disease, the deletion of NK cells had no significant impact on disease onset. NK cells were also not required to promote disease induced by adoptively transferred pathogenic CD4.sup.+ T cells. Thus, NK cells are not required for spontaneous autoimmune diabetes in NOD mice.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0036011
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleNK cells are not required for spontaneous autoimmune diabetes in NOD mice.
creatorBeilke, Joshua N ; Meagher, Craig T ; Hosiawa, Karoline ; Champsaur, Marine ; Bluestone, Jeffrey A ; Lanier, Lewis L
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0036011
subjectAnimals–Immunology ; Cell Differentiation–Metabolism ; Cell Membrane–Metabolism ; Cell Proliferation–Immunology ; Cytokines–Immunology ; Cytotoxicity, Immunologic–Immunology ; Dendritic Cells–Metabolism ; Diabetes Mellitus, Type 1–Pathology ; Disease Progression–Immunology ; Killer Cells, Natural–Pathology ; Liver–Immunology ; Lymphocyte Activation–Immunology ; Mice–Pathology ; Mice, Inbred Nod–Pathology ; Pancreas–Pathology ; Phenotype–Pathology ; Cytokines
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descriptionNK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute induced disease models of diabetes. Yet, the role of NK cells in spontaneous diabetes has not been directly addressed. Here, we used the NOD.NK1.1 congenic mouse model to examine the role of NK cells in spontaneous diabetes. Significant numbers of NK cells were only seen in the pancreas of mice with disease. Pancreatic NK cells displayed an activated surface phenotype and proliferated more than NK cells from other tissues in the diseased mice. Nonetheless, depletion of NK cells had no effect on dendritic cell maturation or T cell proliferation. In spontaneous disease, the deletion of NK cells had no significant impact on disease onset. NK cells were also not required to promote disease induced by adoptively transferred pathogenic CD4.sup.+ T cells. Thus, NK cells are not required for spontaneous autoimmune diabetes in NOD mice.
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