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The Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease.

Adherence to a Mediterranean diet (MD) is associated with a reduced risk of coronary heart disease. However, the molecular mechanisms involved are not fully understood. The aim of this study was to compare the effects of 2 MD with those of a low-fat-diet (LFD) on circulating inflammatory biomarkers... Full description

Journal Title: The Journal of nutrition June 2012, Vol.142(6), pp.1019-1025
Main Author: Urpi-Sarda, Mireia
Other Authors: Casas, Rosa , Chiva-Blanch, Gemma , Romero-Mamani, Edwin Saúl , Valderas-Martínez, Palmira , Salas-Salvadó, Jordi , Covas, María Isabel , Toledo, Estefanía , Andres-Lacueva, Cristina , Llorach, Rafael , García-Arellano, Ana , Bulló, Monica , Ruiz-Gutierrez, Valentina , Lamuela-Raventos, Rosa M , Estruch, Ramon
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1541-6100 ; DOI: 10.3945/jn.111.148726
Link: http://search.proquest.com/docview/1015244088/?pq-origsite=primo
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title: The Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease.
format: Article
creator:
  • Urpi-Sarda, Mireia
  • Casas, Rosa
  • Chiva-Blanch, Gemma
  • Romero-Mamani, Edwin Saúl
  • Valderas-Martínez, Palmira
  • Salas-Salvadó, Jordi
  • Covas, María Isabel
  • Toledo, Estefanía
  • Andres-Lacueva, Cristina
  • Llorach, Rafael
  • García-Arellano, Ana
  • Bulló, Monica
  • Ruiz-Gutierrez, Valentina
  • Lamuela-Raventos, Rosa M
  • Estruch, Ramon
subjects:
  • Aged–Blood
  • Biomarkers–Prevention & Control
  • Cardiovascular Diseases–Metabolism
  • Diet, Mediterranean–Blood
  • Dietary Fats–Metabolism
  • Dietary Supplements–Metabolism
  • Female–Metabolism
  • Humans–Metabolism
  • Inflammation–Metabolism
  • Male–Metabolism
  • Middle Aged–Metabolism
  • Nuts–Metabolism
  • Olive Oil–Metabolism
  • Plant Oils–Metabolism
  • Receptors, Tumor Necrosis Factor, Type I–Metabolism
  • Risk Factors–Metabolism
  • Biomarkers
  • Dietary Fats
  • Olive Oil
  • Plant Oils
  • Receptors, Tumor Necrosis Factor, Type I
ispartof: The Journal of nutrition, June 2012, Vol.142(6), pp.1019-1025
description: Adherence to a Mediterranean diet (MD) is associated with a reduced risk of coronary heart disease. However, the molecular mechanisms involved are not fully understood. The aim of this study was to compare the effects of 2 MD with those of a low-fat-diet (LFD) on circulating inflammatory biomarkers related to atherogenesis. A total of 516 participants included in the Prevention with Mediterranean Diet Study were randomized into 3 intervention groups [MD supplemented with virgin olive oil (MD-VOO); MD supplemented with mixed nuts (MD-Nuts); and LFD]. At baseline and after 1 y, participants completed FFQ and adherence to MD questionnaires, and plasma concentrations of inflammatory markers including intercellular adhesion molecule-1 (ICAM-1), IL-6, and 2 TNF receptors (TNFR60 and TNFR80) were measured by ELISA. At 1 y, the MD groups had lower plasma concentrations of IL-6, TNFR60, and TNFR80 (P < 0.05), whereas ICAM-1, TNFR60, and TNFR80 concentrations increased in the LFD group (P < 0.002). Due to between-group differences, participants in the 2 MD groups had lower plasma concentrations of ICAM-1, IL-6, TNFR60, and TNFR80 compared to those in the LFD group (P [less than or equal] 0.028). When participants were categorized in tertiles of 1-y changes in the consumption of selected foods, those in the highest tertile of virgin olive oil (VOO) and vegetable consumption had a lower plasma TNFR60 concentration compared with those in tertile 1 (P< 0.02). Moreover, the only changes in consumption that were associated with 1 -y changes in the geometric mean TNFR60 concentrations were those of VOO and vegetables (P = 0.01). This study suggests that a MD reduces TNFR concentrations in patients at high cardiovascular risk. doi: 10.3945/jn.111.148726.
language: eng
source:
identifier: E-ISSN: 1541-6100 ; DOI: 10.3945/jn.111.148726
fulltext: fulltext
issn:
  • 15416100
  • 1541-6100
url: Link


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titleThe Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease.
creatorUrpi-Sarda, Mireia ; Casas, Rosa ; Chiva-Blanch, Gemma ; Romero-Mamani, Edwin Saúl ; Valderas-Martínez, Palmira ; Salas-Salvadó, Jordi ; Covas, María Isabel ; Toledo, Estefanía ; Andres-Lacueva, Cristina ; Llorach, Rafael ; García-Arellano, Ana ; Bulló, Monica ; Ruiz-Gutierrez, Valentina ; Lamuela-Raventos, Rosa M ; Estruch, Ramon
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ispartofThe Journal of nutrition, June 2012, Vol.142(6), pp.1019-1025
identifierE-ISSN: 1541-6100 ; DOI: 10.3945/jn.111.148726
subjectAged–Blood ; Biomarkers–Prevention & Control ; Cardiovascular Diseases–Metabolism ; Diet, Mediterranean–Blood ; Dietary Fats–Metabolism ; Dietary Supplements–Metabolism ; Female–Metabolism ; Humans–Metabolism ; Inflammation–Metabolism ; Male–Metabolism ; Middle Aged–Metabolism ; Nuts–Metabolism ; Olive Oil–Metabolism ; Plant Oils–Metabolism ; Receptors, Tumor Necrosis Factor, Type I–Metabolism ; Risk Factors–Metabolism ; Biomarkers ; Dietary Fats ; Olive Oil ; Plant Oils ; Receptors, Tumor Necrosis Factor, Type I
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descriptionAdherence to a Mediterranean diet (MD) is associated with a reduced risk of coronary heart disease. However, the molecular mechanisms involved are not fully understood. The aim of this study was to compare the effects of 2 MD with those of a low-fat-diet (LFD) on circulating inflammatory biomarkers related to atherogenesis. A total of 516 participants included in the Prevention with Mediterranean Diet Study were randomized into 3 intervention groups [MD supplemented with virgin olive oil (MD-VOO); MD supplemented with mixed nuts (MD-Nuts); and LFD]. At baseline and after 1 y, participants completed FFQ and adherence to MD questionnaires, and plasma concentrations of inflammatory markers including intercellular adhesion molecule-1 (ICAM-1), IL-6, and 2 TNF receptors (TNFR60 and TNFR80) were measured by ELISA. At 1 y, the MD groups had lower plasma concentrations of IL-6, TNFR60, and TNFR80 (P < 0.05), whereas ICAM-1, TNFR60, and TNFR80 concentrations increased in the LFD group (P < 0.002). Due to between-group differences, participants in the 2 MD groups had lower plasma concentrations of ICAM-1, IL-6, TNFR60, and TNFR80 compared to those in the LFD group (P [less than or equal] 0.028). When participants were categorized in tertiles of 1-y changes in the consumption of selected foods, those in the highest tertile of virgin olive oil (VOO) and vegetable consumption had a lower plasma TNFR60 concentration compared with those in tertile 1 (P< 0.02). Moreover, the only changes in consumption that were associated with 1 -y changes in the geometric mean TNFR60 concentrations were those of VOO and vegetables (P = 0.01). This study suggests that a MD reduces TNFR concentrations in patients at high cardiovascular risk. doi: 10.3945/jn.111.148726.
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titleThe Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease.
authorUrpi-Sarda, Mireia ; Casas, Rosa ; Chiva-Blanch, Gemma ; Romero-Mamani, Edwin Saúl ; Valderas-Martínez, Palmira ; Salas-Salvadó, Jordi ; Covas, María Isabel ; Toledo, Estefanía ; Andres-Lacueva, Cristina ; Llorach, Rafael ; García-Arellano, Ana ; Bulló, Monica ; Ruiz-Gutierrez, Valentina ; Lamuela-Raventos,...
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