schliessen

Filtern

 

Bibliotheken

Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.

Removal of the parametrial fat pads (partial lipectomy) from female SKH-1 mice fed a high-fat diet inhibited UVB-induced carcinogenesis, but this was not observed in mice fed a low-fat chow diet. Partial lipectomy in high-fat-fed mice decreased the number of keratoacanthomas and squamous cell carcin... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America June 5, 2012, Vol.109(23), pp.9065-9070
Main Author: Lu, Yao-Ping
Other Authors: Lou, You-Rong , Bernard, Jamie J , Peng, Qing-Yun , Li, Tao , Lin, Yong , Shih, Weichung Joe , Nghiem, Paul , Shapses, Sue , Wagner, George C , Conney, Allan H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; DOI: 1091-6490 ; DOI: 10.1073/pnas.1205810109
Link: http://search.proquest.com/docview/1019099004/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1019099004
title: Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.
format: Article
creator:
  • Lu, Yao-Ping
  • Lou, You-Rong
  • Bernard, Jamie J
  • Peng, Qing-Yun
  • Li, Tao
  • Lin, Yong
  • Shih, Weichung Joe
  • Nghiem, Paul
  • Shapses, Sue
  • Wagner, George C
  • Conney, Allan H
subjects:
  • Absorptiometry, Photon–Surgery
  • Adipose Tissue–Physiology
  • Animals–Prevention & Control
  • Apoptosis–Surgery
  • Bromodeoxyuridine–Prevention & Control
  • Carcinoma, Squamous Cell–Surgery
  • Caspase 3–Methods
  • Diet, High-Fat–Prevention & Control
  • Female–Surgery
  • Immunohistochemistry–Surgery
  • Keratoacanthoma–Surgery
  • Lipectomy–Surgery
  • Mice–Surgery
  • Neoplasms, Radiation-Induced–Surgery
  • Reverse Transcriptase Polymerase Chain Reaction–Surgery
  • Ultraviolet Rays–Surgery
  • Caspase 3
  • Bromodeoxyuridine
ispartof: Proceedings of the National Academy of Sciences of the United States of America, June 5, 2012, Vol.109(23), pp.9065-9070
description: Removal of the parametrial fat pads (partial lipectomy) from female SKH-1 mice fed a high-fat diet inhibited UVB-induced carcinogenesis, but this was not observed in mice fed a low-fat chow diet. Partial lipectomy in high-fat-fed mice decreased the number of keratoacanthomas and squamous cell carcinomas per mouse by 76 and 79%, respectively, compared with sham-operated control mice irradiated with UVB for 33 wk. Immunohistochemical analysis indicated that partial lipectomy increased caspase 3 (active form) positive cells by 48% in precancerous epidermis away from tumors, by 68% in keratoacanthomas, and by 224% in squamous cell carcinomas compared with sham-operated control mice. In addition, partial lipectomy decreased cell proliferation away from tumors and in tumors. RT-PCR analysis for adipokines revealed that mRNAs for TIMP1, MCP1, and SerpinE1 (proinflammatory/antiapoptotic cytokines) in the parametrial fat pads of sham-operated control mice were 54- to 83-fold higher than levels in compensatory fat that returned after surgery in partially lipectomized mice at the end of the tumor study. Feeding mice high-fat diets for 2 wk increased levels of TIMP1 and other adipokines in serum and epidermis, and these increases were inhibited by removal of the parametrial fat pads. Our results are a unique demonstration that surgical removal of a specific tissue fat results in inhibition of carcinogenesis in obese mice. This inhibition was associated with an increase in apoptosis and a decrease in proliferation in tumors and in precancerous areas away from tumors. obesity | skin cancer doi/10.1073/pnas.1205810109
language: eng
source:
identifier: E-ISSN: 1091-6490 ; DOI: 1091-6490 ; DOI: 10.1073/pnas.1205810109
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


@attributes
ID1188762734
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1019099004
sourceidproquest
recordidTN_proquest1019099004
sourcesystemOther
pqid1019099004
galeid294505280
display
typearticle
titleSurgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.
creatorLu, Yao-Ping ; Lou, You-Rong ; Bernard, Jamie J ; Peng, Qing-Yun ; Li, Tao ; Lin, Yong ; Shih, Weichung Joe ; Nghiem, Paul ; Shapses, Sue ; Wagner, George C ; Conney, Allan H
contributorLu, Yao-Ping (correspondence author) ; Lu, Yao-Ping (record owner)
ispartofProceedings of the National Academy of Sciences of the United States of America, June 5, 2012, Vol.109(23), pp.9065-9070
identifier
subjectAbsorptiometry, Photon–Surgery ; Adipose Tissue–Physiology ; Animals–Prevention & Control ; Apoptosis–Surgery ; Bromodeoxyuridine–Prevention & Control ; Carcinoma, Squamous Cell–Surgery ; Caspase 3–Methods ; Diet, High-Fat–Prevention & Control ; Female–Surgery ; Immunohistochemistry–Surgery ; Keratoacanthoma–Surgery ; Lipectomy–Surgery ; Mice–Surgery ; Neoplasms, Radiation-Induced–Surgery ; Reverse Transcriptase Polymerase Chain Reaction–Surgery ; Ultraviolet Rays–Surgery ; Caspase 3 ; Bromodeoxyuridine
languageeng
source
descriptionRemoval of the parametrial fat pads (partial lipectomy) from female SKH-1 mice fed a high-fat diet inhibited UVB-induced carcinogenesis, but this was not observed in mice fed a low-fat chow diet. Partial lipectomy in high-fat-fed mice decreased the number of keratoacanthomas and squamous cell carcinomas per mouse by 76 and 79%, respectively, compared with sham-operated control mice irradiated with UVB for 33 wk. Immunohistochemical analysis indicated that partial lipectomy increased caspase 3 (active form) positive cells by 48% in precancerous epidermis away from tumors, by 68% in keratoacanthomas, and by 224% in squamous cell carcinomas compared with sham-operated control mice. In addition, partial lipectomy decreased cell proliferation away from tumors and in tumors. RT-PCR analysis for adipokines revealed that mRNAs for TIMP1, MCP1, and SerpinE1 (proinflammatory/antiapoptotic cytokines) in the parametrial fat pads of sham-operated control mice were 54- to 83-fold higher than levels in compensatory fat that returned after surgery in partially lipectomized mice at the end of the tumor study. Feeding mice high-fat diets for 2 wk increased levels of TIMP1 and other adipokines in serum and epidermis, and these increases were inhibited by removal of the parametrial fat pads. Our results are a unique demonstration that surgical removal of a specific tissue fat results in inhibition of carcinogenesis in obese mice. This inhibition was associated with an increase in apoptosis and a decrease in proliferation in tumors and in precancerous areas away from tumors. obesity | skin cancer doi/10.1073/pnas.1205810109
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1019099004/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Lu, Yao-Ping
1Lou, You-Rong
2Bernard, Jamie J
3Peng, Qing-Yun
4Li, Tao
5Lin, Yong
6Shih, Weichung Joe
7Nghiem, Paul
8Shapses, Sue
9Wagner, George C
10Conney, Allan H
titleSurgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.
subject
0Absorptiometry, Photon–Surgery
1Adipose Tissue–Physiology
2Animals–Prevention & Control
3Apoptosis–Surgery
4Bromodeoxyuridine–Prevention & Control
5Carcinoma, Squamous Cell–Surgery
6Caspase 3–Methods
7Diet, High-Fat–Prevention & Control
8Female–Surgery
9Immunohistochemistry–Surgery
10Keratoacanthoma–Surgery
11Lipectomy–Surgery
12Mice–Surgery
13Neoplasms, Radiation-Induced–Surgery
14Reverse Transcriptase Polymerase Chain Reaction–Surgery
15Ultraviolet Rays–Surgery
16Caspase 3
17Bromodeoxyuridine
general
0English
11091-6490
210.1073/pnas.1205810109
3MEDLINE (ProQuest)
4ProQuest Biological Science Collection
5ProQuest Natural Science Collection
6ProQuest SciTech Collection
7Biological Science Database
8Natural Science Collection
9SciTech Premium Collection
10Health Research Premium Collection
11Health Research Premium Collection (Alumni edition)
sourceidproquest
recordidproquest1019099004
issn
010916490
11091-6490
rsrctypearticle
creationdate2012
addtitleProceedings of the National Academy of Sciences of the United States of America
searchscope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
scope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
lsr43
01007527false
11007944false
210000004false
310000038false
410000050false
510000120false
610000159false
710000238false
810000253false
910000260false
1010000270false
1110000271false
1210000302false
contributorLu, Yao-Ping
startdate20120605
enddate20120605
citationpf 9065 pt 9070 vol 109 issue 23
lsr30VSR-Enriched:[pqid, issn, description, galeid]
sort
titleSurgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.
authorLu, Yao-Ping ; Lou, You-Rong ; Bernard, Jamie J ; Peng, Qing-Yun ; Li, Tao ; Lin, Yong ; Shih, Weichung Joe ; Nghiem, Paul ; Shapses, Sue ; Wagner, George C ; Conney, Allan H
creationdate20120605
lso0120120605
facets
frbrgroupid8815874966807998519
frbrtype5
newrecords20181218
languageeng
creationdate2012
topic
0Absorptiometry, Photon–Surgery
1Adipose Tissue–Physiology
2Animals–Prevention & Control
3Apoptosis–Surgery
4Bromodeoxyuridine–Prevention & Control
5Carcinoma, Squamous Cell–Surgery
6Caspase 3–Methods
7Diet, High-Fat–Prevention & Control
8Female–Surgery
9Immunohistochemistry–Surgery
10Keratoacanthoma–Surgery
11Lipectomy–Surgery
12Mice–Surgery
13Neoplasms, Radiation-Induced–Surgery
14Reverse Transcriptase Polymerase Chain Reaction–Surgery
15Ultraviolet Rays–Surgery
16Caspase 3
17Bromodeoxyuridine
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
prefilterarticles
rsrctypearticles
creatorcontrib
0Lu, Yao-Ping
1Lou, You-Rong
2Bernard, Jamie J
3Peng, Qing-Yun
4Li, Tao
5Lin, Yong
6Shih, Weichung Joe
7Nghiem, Paul
8Shapses, Sue
9Wagner, George C
10Conney, Allan H
jtitleProceedings of the National Academy of Sciences of the United States of America
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Lu
1Lou
2Bernard
3Peng
4Li
5Lin
6Shih
7Nghiem
8Shapses
9Wagner
10Conney
aufirst
0Yao-Ping
1You-Rong
2Jamie J
3Qing-Yun
4Tao
5Yong
6Weichung Joe
7Paul
8Sue
9George C
10Allan H
au
0Lu, Yao-Ping
1Lou, You-Rong
2Bernard, Jamie J
3Peng, Qing-Yun
4Li, Tao
5Lin, Yong
6Shih, Weichung Joe
7Nghiem, Paul
8Shapses, Sue
9Wagner, George C
10Conney, Allan H
addauLu, Yao-Ping
atitleSurgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.
jtitleProceedings of the National Academy of Sciences of the United States of America
risdate20120605
volume109
issue23
spage9065
epage9070
pages9065-9070
eissn1091-6490
formatjournal
genrearticle
ristypeJOUR
doi10.1073/pnas.1205810109
urlhttp://search.proquest.com/docview/1019099004/
issn00278424
date2012-06-05