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The NIH experience in first advancing fMRI.

The introduction of functional MRI at NIH in 1992 was the outcome of research goals first formulated by Turner in 1983. Between 1988 and 1990, Turner worked at NIH on actively-shielded gradient coils and the implementation of EPI-based techniques, especially diffusion-weighted EPI. His work on hypox... Full description

Journal Title: NeuroImage Vol.62(2), pp.632-636
Main Author: Turner, Robert
Format: Electronic Article Electronic Article
Language: English
Subjects:
Created: August 15, 2012
ID: E-ISSN: 1095-9572 ; DOI: 1095-9572 ; DOI: 10.1016/j.neuroimage.2011.07.074
Link: http://search.proquest.com/docview/1023292772/?pq-origsite=primo
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recordid: proquest1023292772
title: The NIH experience in first advancing fMRI.
format: Article
creator:
  • Turner, Robert
subjects:
  • Animals–Blood Supply
  • Brain–History
  • Brain Mapping–Methods
  • History, 20th Century–History
  • History, 21st Century–Methods
  • Humans–Blood
  • Magnetic Resonance Imaging–Blood
  • National Institutes of Health (U.S.)–Blood
  • Oxygen–Blood
  • United States–Blood
  • Oxygen
ispartof: NeuroImage, Vol.62(2), pp.632-636
description: The introduction of functional MRI at NIH in 1992 was the outcome of research goals first formulated by Turner in 1983. Between 1988 and 1990, Turner worked at NIH on actively-shielded gradient coils and the implementation of EPI-based techniques, especially diffusion-weighted EPI. His work on hypoxia in cat brain in 1990 directly inspired Ken Kwong's demonstration of BOLD contrast in humans at MGH in May 1991. Turner collaborated actively with this MGH team, the first group to map entirely noninvasively human brain activity due to visual stimulation. He introduced BOLD fMRI at NIH in February 1992. This paper reviews the steps that led up to BOLD EPI, and Turner's initial applications of BOLD fMRI at NIH. ► Motivation for investigation of BOLD contrast. ► Value of EPI data acquisition. ► Detailed chronology of first experiments. ► Response of NIH neuroscientists to successful BOLD fMRI.
language: eng
source:
identifier: E-ISSN: 1095-9572 ; DOI: 1095-9572 ; DOI: 10.1016/j.neuroimage.2011.07.074
fulltext: fulltext
issn:
  • 10959572
  • 1095-9572
url: Link


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