schliessen

Filtern

 

Bibliotheken

Calibrated FMRI.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.02.022 Byline: Richard D. Hoge Keywords: Calibrated MRI; fMRI; Hypercapnia; Hyperoxia; BOLD; Oxygen; Metabolism Abstract: Functional magnetic resonance imaging with blood oxygenation level-depe... Full description

Journal Title: NeuroImage August 15, 2012, Vol.62(2), pp.930-937
Main Author: Hoge, Richard D
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.02.022
Link: http://search.proquest.com/docview/1023294159/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1023294159
title: Calibrated FMRI.
format: Article
creator:
  • Hoge, Richard D
subjects:
  • Brain–Anatomy & Histology
  • Brain Mapping–Physiology
  • Calibration–History
  • History, 20th Century–Methods
  • History, 21st Century–History
  • Humans–Methods
  • Magnetic Resonance Imaging–Blood
  • Oxygen–Physiology
  • Oxygen Consumption–Physiology
  • Oxygen
ispartof: NeuroImage, August 15, 2012, Vol.62(2), pp.930-937
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.02.022 Byline: Richard D. Hoge Keywords: Calibrated MRI; fMRI; Hypercapnia; Hyperoxia; BOLD; Oxygen; Metabolism Abstract: Functional magnetic resonance imaging with blood oxygenation level-dependent (BOLD) contrast has had a tremendous influence on human neuroscience in the last twenty years, providing a non-invasive means of mapping human brain function with often exquisite sensitivity and detail. However the BOLD method remains a largely qualitative approach. While the same can be said of anatomic MRI techniques, whose clinical and research impact has not been diminished in the slightest by the lack of a quantitative interpretation of their image intensity, the quantitative expression of BOLD responses as a percent of the baseline T2*- weighted signal has been viewed as necessary since the earliest days of fMRI. Calibrated MRI attempts to dissociate changes in oxygen metabolism from changes in blood flow and volume, the latter three quantities contributing jointly to determine the physiologically ambiguous percent BOLD change. This dissociation is typically performed using a "calibration" procedure in which subjects inhale a gas mixture containing small amounts of carbon dioxide or enriched oxygen to produce changes in blood flow and BOLD signal which can be measured under well-defined hemodynamic conditions. The outcome is a calibration parameter M which can then be substituted into an expression providing the fractional change in oxygen metabolism given changes in blood flow and BOLD signal during a task. The latest generation of calibrated MRI methods goes beyond fractional changes to provide absolute quantification of resting-state oxygen consumption in micromolar units, in addition to absolute measures of evoked metabolic response. This review discusses the history, challenges, and advances in calibrated MRI, from the personal perspective of the author. Article History: Accepted 9 February 2012
language: eng
source:
identifier: E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.02.022
fulltext: fulltext
issn:
  • 10959572
  • 1095-9572
url: Link


@attributes
ID1127326630
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1023294159
sourceidproquest
recordidTN_proquest1023294159
sourcesystemPC
pqid1023294159
galeid294940001
display
typearticle
titleCalibrated FMRI.
creatorHoge, Richard D
contributorHoge, Richard D (correspondence author) ; Hoge, Richard D (record owner)
ispartofNeuroImage, August 15, 2012, Vol.62(2), pp.930-937
identifierE-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.02.022
subjectBrain–Anatomy & Histology ; Brain Mapping–Physiology ; Calibration–History ; History, 20th Century–Methods ; History, 21st Century–History ; Humans–Methods ; Magnetic Resonance Imaging–Blood ; Oxygen–Physiology ; Oxygen Consumption–Physiology ; Oxygen
languageeng
source
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.02.022 Byline: Richard D. Hoge Keywords: Calibrated MRI; fMRI; Hypercapnia; Hyperoxia; BOLD; Oxygen; Metabolism Abstract: Functional magnetic resonance imaging with blood oxygenation level-dependent (BOLD) contrast has had a tremendous influence on human neuroscience in the last twenty years, providing a non-invasive means of mapping human brain function with often exquisite sensitivity and detail. However the BOLD method remains a largely qualitative approach. While the same can be said of anatomic MRI techniques, whose clinical and research impact has not been diminished in the slightest by the lack of a quantitative interpretation of their image intensity, the quantitative expression of BOLD responses as a percent of the baseline T2*- weighted signal has been viewed as necessary since the earliest days of fMRI. Calibrated MRI attempts to dissociate changes in oxygen metabolism from changes in blood flow and volume, the latter three quantities contributing jointly to determine the physiologically ambiguous percent BOLD change. This dissociation is typically performed using a "calibration" procedure in which subjects inhale a gas mixture containing small amounts of carbon dioxide or enriched oxygen to produce changes in blood flow and BOLD signal which can be measured under well-defined hemodynamic conditions. The outcome is a calibration parameter M which can then be substituted into an expression providing the fractional change in oxygen metabolism given changes in blood flow and BOLD signal during a task. The latest generation of calibrated MRI methods goes beyond fractional changes to provide absolute quantification of resting-state oxygen consumption in micromolar units, in addition to absolute measures of evoked metabolic response. This review discusses the history, challenges, and advances in calibrated MRI, from the personal perspective of the author. Article History: Accepted 9 February 2012
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1023294159/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontribHoge, Richard D
titleCalibrated FMRI.
subject
0Brain–Anatomy & Histology
1Brain Mapping–Physiology
2Calibration–History
3History, 20th Century–Methods
4History, 21st Century–History
5Humans–Methods
6Magnetic Resonance Imaging–Blood
7Oxygen–Physiology
8Oxygen Consumption–Physiology
9Oxygen
general
0English
110.1016/j.neuroimage.2012.02.022
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1023294159
issn
010959572
11095-9572
rsrctypearticle
creationdate2012
addtitleNeuroImage
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorHoge, Richard D
startdate20120815
enddate20120815
citationpf 930 pt 937 vol 62 issue 2
lsr30VSR-Enriched:[pqid, issn, description, galeid]
sort
titleCalibrated FMRI.
authorHoge, Richard D
creationdate20120815
lso0120120815
facets
frbrgroupid2142348735650479127
frbrtype5
newrecords20181218
languageeng
creationdate2012
topic
0Brain–Anatomy & Histology
1Brain Mapping–Physiology
2Calibration–History
3History, 20th Century–Methods
4History, 21st Century–History
5Humans–Methods
6Magnetic Resonance Imaging–Blood
7Oxygen–Physiology
8Oxygen Consumption–Physiology
9Oxygen
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontribHoge, Richard D
jtitleNeuroImage
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulastHoge
aufirstRichard D
auHoge, Richard D
addauHoge, Richard D
atitleCalibrated FMRI.
jtitleNeuroImage
risdate20120815
volume62
issue2
spage930
epage937
pages930-937
eissn1095-9572
formatjournal
genrearticle
ristypeJOUR
doi10.1016/j.neuroimage.2012.02.022
urlhttp://search.proquest.com/docview/1023294159/
issn10538119
date2012-08-15