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Array-based disease diagnostics using lipid/polydiacetylene vesicles encapsulated in a sol-gel matrix.

We demonstrate a novel array-based diagnostic platform comprising lipid/polydiacetylene (PDA) vesicles embedded within a transparent silica-gel matrix. The diagnostic scheme is based upon the unique chromatic properties of PDA, which undergoes blue-red transformations induced by interactions with am... Full description

Journal Title: Analytical chemistry July 17, 2012, Vol.84(14), pp.5925-5931
Main Author: Kolusheva, S
Other Authors: Yossef, R , Kugel, A , Katz, M , Volinsky, R , Welt, M , Hadad, U , Drory, V , Kliger, M , Rubin, E , Porgador, A , Jelinek, R
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-6882 ; DOI: 1520-6882 ; DOI: 10.1021/ac300449u
Link: http://search.proquest.com/docview/1027682549/?pq-origsite=primo
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recordid: proquest1027682549
title: Array-based disease diagnostics using lipid/polydiacetylene vesicles encapsulated in a sol-gel matrix.
format: Article
creator:
  • Kolusheva, S
  • Yossef, R
  • Kugel, A
  • Katz, M
  • Volinsky, R
  • Welt, M
  • Hadad, U
  • Drory, V
  • Kliger, M
  • Rubin, E
  • Porgador, A
  • Jelinek, R
subjects:
  • Adult–Blood
  • Aged–Diagnosis
  • Aged, 80 and Over–Instrumentation
  • Amyotrophic Lateral Sclerosis–Blood
  • Capsules–Diagnosis
  • Colorimetry–Chemistry
  • Diagnosis, Differential–Chemistry
  • Female–Chemistry
  • Humans–Chemistry
  • Inflammatory Bowel Diseases–Chemistry
  • Lipids–Chemistry
  • Male–Chemistry
  • Middle Aged–Chemistry
  • Polyacetylenes–Chemistry
  • Polymers–Chemistry
  • Silica Gel–Chemistry
  • Young Adult–Chemistry
  • Capsules
  • Lipids
  • Polymers
  • Polyacetylenes
  • Polydiacetylene
  • Silica Gel
ispartof: Analytical chemistry, July 17, 2012, Vol.84(14), pp.5925-5931
description: We demonstrate a novel array-based diagnostic platform comprising lipid/polydiacetylene (PDA) vesicles embedded within a transparent silica-gel matrix. The diagnostic scheme is based upon the unique chromatic properties of PDA, which undergoes blue-red transformations induced by interactions with amphiphilic or membrane-active analytes. We show that constructing a gel matrix array hosting PDA vesicles with different lipid compositions and applying to blood plasma obtained from healthy individuals and from patients suffering from disease, respectively, allow distinguishing among the disease conditions through application of a simple machine-learning algorithm, using the colorimetric response of the lipid/PDA/gel matrix as the input. Importantly, the new colorimetric diagnostic approach does not require a priori knowledge on the exact metabolite compositions of the blood plasma, since the concept relies only on identifying statistically significant changes in overall disease-induced chromatic response. The chromatic lipid/PDA/gel array-based "fingerprinting" concept is generic, easy to apply, and could be implemented for varied diagnostic and screening applications. [PUBLICATION ]
language: eng
source:
identifier: E-ISSN: 1520-6882 ; DOI: 1520-6882 ; DOI: 10.1021/ac300449u
fulltext: no_fulltext
issn:
  • 15206882
  • 1520-6882
url: Link


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titleArray-based disease diagnostics using lipid/polydiacetylene vesicles encapsulated in a sol-gel matrix.
creatorKolusheva, S ; Yossef, R ; Kugel, A ; Katz, M ; Volinsky, R ; Welt, M ; Hadad, U ; Drory, V ; Kliger, M ; Rubin, E ; Porgador, A ; Jelinek, R
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subjectAdult–Blood ; Aged–Diagnosis ; Aged, 80 and Over–Instrumentation ; Amyotrophic Lateral Sclerosis–Blood ; Capsules–Diagnosis ; Colorimetry–Chemistry ; Diagnosis, Differential–Chemistry ; Female–Chemistry ; Humans–Chemistry ; Inflammatory Bowel Diseases–Chemistry ; Lipids–Chemistry ; Male–Chemistry ; Middle Aged–Chemistry ; Polyacetylenes–Chemistry ; Polymers–Chemistry ; Silica Gel–Chemistry ; Young Adult–Chemistry ; Capsules ; Lipids ; Polymers ; Polyacetylenes ; Polydiacetylene ; Silica Gel
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descriptionWe demonstrate a novel array-based diagnostic platform comprising lipid/polydiacetylene (PDA) vesicles embedded within a transparent silica-gel matrix. The diagnostic scheme is based upon the unique chromatic properties of PDA, which undergoes blue-red transformations induced by interactions with amphiphilic or membrane-active analytes. We show that constructing a gel matrix array hosting PDA vesicles with different lipid compositions and applying to blood plasma obtained from healthy individuals and from patients suffering from disease, respectively, allow distinguishing among the disease conditions through application of a simple machine-learning algorithm, using the colorimetric response of the lipid/PDA/gel matrix as the input. Importantly, the new colorimetric diagnostic approach does not require a priori knowledge on the exact metabolite compositions of the blood plasma, since the concept relies only on identifying statistically significant changes in overall disease-induced chromatic response. The chromatic lipid/PDA/gel array-based "fingerprinting" concept is generic, easy to apply, and could be implemented for varied diagnostic and screening applications. [PUBLICATION ]
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