schliessen

Filtern

 

Bibliotheken

Cationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status.

Cationic liposome formulations can function as efficient vaccine adjuvants. However, due to the highly diverse nature of lipids, cationic liposomes have different physical-chemical characteristics that influence their adjuvant mechanisms and their relevance for use in different vaccines. These chara... Full description

Journal Title: Expert review of vaccines May 2012, Vol.11(5), pp.561-577
Main Author: Korsholm, Karen Smith
Other Authors: Andersen, Peter Lawætz , Christensen, Dennis
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1744-8395 ; DOI: 10.1586/erv.12.22
Link: http://search.proquest.com/docview/1028016648/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1028016648
title: Cationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status.
format: Article
creator:
  • Korsholm, Karen Smith
  • Andersen, Peter Lawætz
  • Christensen, Dennis
subjects:
  • Adjuvants, Immunologic–Administration & Dosage
  • Animals–Chemistry
  • Clinical Trials As Topic–Chemistry
  • Disease Models, Animal–Immunology
  • Drug Delivery Systems–Administration & Dosage
  • Guinea Pigs–Administration & Dosage
  • Humans–Administration & Dosage
  • Liposomes–Administration & Dosage
  • Mice–Administration & Dosage
  • Rats–Administration & Dosage
  • Vaccines–Administration & Dosage
  • Adjuvants, Immunologic
  • Liposomes
  • Vaccines
ispartof: Expert review of vaccines, May 2012, Vol.11(5), pp.561-577
description: Cationic liposome formulations can function as efficient vaccine adjuvants. However, due to the highly diverse nature of lipids, cationic liposomes have different physical-chemical characteristics that influence their adjuvant mechanisms and their relevance for use in different vaccines. These characteristics can be further manipulated by incorporation of additional lipids or stabilizers, and inclusion of carefully selected immunostimulators is a feasible strategy when tailoring cationic liposomal adjuvants for specific disease targets. Thus, cationic liposomes present a plasticity, which makes them promising adjuvants for future vaccines. This versatility has also led to a vast amount of literature on different experimental liposomal formulations in combination with a wide range of immunostimulators. Here, we have compiled information about the animal challenge models and administration routes that have been used to study vaccine adjuvants based on cationic liposomes and provide an overview of the applicability, progress and clinical status of cationic liposomal vaccine adjuvants.
language: eng
source:
identifier: E-ISSN: 1744-8395 ; DOI: 10.1586/erv.12.22
fulltext: fulltext
issn:
  • 17448395
  • 1744-8395
url: Link


@attributes
ID1483684954
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1028016648
sourceidproquest
recordidTN_proquest1028016648
sourcesystemPC
pqid1028016648
galeid293067195
ingidftd/erv/2012/00000011/00000005/art00008
display
typearticle
titleCationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status.
creatorKorsholm, Karen Smith ; Andersen, Peter Lawætz ; Christensen, Dennis
contributorKorsholm, Karen Smith (correspondence author) ; Korsholm, Karen Smith (record owner)
ispartofExpert review of vaccines, May 2012, Vol.11(5), pp.561-577
identifierE-ISSN: 1744-8395 ; DOI: 10.1586/erv.12.22
subject
languageeng
source
descriptionCationic liposome formulations can function as efficient vaccine adjuvants. However, due to the highly diverse nature of lipids, cationic liposomes have different physical-chemical characteristics that influence their adjuvant mechanisms and their relevance for use in different vaccines. These characteristics can be further manipulated by incorporation of additional lipids or stabilizers, and inclusion of carefully selected immunostimulators is a feasible strategy when tailoring cationic liposomal adjuvants for specific disease targets. Thus, cationic liposomes present a plasticity, which makes them promising adjuvants for future vaccines. This versatility has also led to a vast amount of literature on different experimental liposomal formulations in combination with a wide range of immunostimulators. Here, we have compiled information about the animal challenge models and administration routes that have been used to study vaccine adjuvants based on cationic liposomes and provide an overview of the applicability, progress and clinical status of cationic liposomal vaccine adjuvants.
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1028016648/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Korsholm, Karen Smith
1Andersen, Peter Lawætz
2Christensen, Dennis
titleCationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status.
subject
0Adjuvants, Immunologic–Administration & Dosage
1Animals–Chemistry
2Clinical Trials As Topic–Chemistry
3Disease Models, Animal–Immunology
4Drug Delivery Systems–Administration & Dosage
5Guinea Pigs–Administration & Dosage
6Humans–Administration & Dosage
7Liposomes–Administration & Dosage
8Mice–Administration...
general
0English
110.1586/erv.12.22
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1028016648
issn
017448395
11744-8395
rsrctypearticle
creationdate2012
addtitleExpert review of vaccines
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorKorsholm, Karen Smith
startdate20120501
enddate20120501
citationpf 561 pt 577 vol 11 issue 5
lsr30VSR-Enriched:[ingid, galeid, description, pqid, issn]
sort
titleCationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status.
authorKorsholm, Karen Smith ; Andersen, Peter Lawætz ; Christensen, Dennis
creationdate20120501
lso0120120501
facets
frbrgroupid8574971282662074877
frbrtype5
newrecords20181218
languageeng
creationdate2012
topic
0Adjuvants, Immunologic–Administration & Dosage
1Animals–Chemistry
2Clinical Trials As Topic–Chemistry
3Disease Models, Animal–Immunology
4Drug Delivery Systems–Administration & Dosage
5Guinea Pigs–Administration & Dosage
6Humans–Administration & Dosage
7Liposomes–Administration & Dosage
8Mice–Administration...
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Korsholm, Karen Smith
1Andersen, Peter Lawætz
2Christensen, Dennis
jtitleExpert review of vaccines
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Korsholm
1Andersen
2Christensen
aufirst
0Karen Smith
1Peter Lawætz
2Dennis
au
0Korsholm, Karen Smith
1Andersen, Peter Lawætz
2Christensen, Dennis
addauKorsholm, Karen Smith
atitleCationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status.
jtitleExpert review of vaccines
risdate20120501
volume11
issue5
spage561
epage577
pages561-577
eissn1744-8395
formatjournal
genrearticle
ristypeJOUR
doi10.1586/erv.12.22
urlhttp://search.proquest.com/docview/1028016648/
issn14760584
date2012-05-01