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Transcriptional consequences of aneuploidy.

Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and the consequences of aneuploidy on cell physiology remain poorly understood. We have performed a metaanalysis on gene expressi... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America July 31, 2012, Vol.109(31), pp.12644-12649
Main Author: Sheltzer, Jason M
Other Authors: Torres, Eduardo M , Dunham, Maitreya J , Amon, Angelika
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1209227109
Link: http://search.proquest.com/docview/1030873764/?pq-origsite=primo
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recordid: proquest1030873764
title: Transcriptional consequences of aneuploidy.
format: Article
creator:
  • Sheltzer, Jason M
  • Torres, Eduardo M
  • Dunham, Maitreya J
  • Amon, Angelika
subjects:
  • Aneuploidy–Genetics
  • Animals–Metabolism
  • Arabidopsis–Physiology
  • Cell Line–Physiology
  • Gene Expression Regulation, Fungal–Genetics
  • Gene Expression Regulation, Plant–Metabolism
  • Humans–Genetics
  • Mice–Metabolism
  • Saccharomyces Cerevisiae–Physiology
  • Schizosaccharomyces–Physiology
  • Species Specificity–Physiology
  • Transcription, Genetic–Physiology
ispartof: Proceedings of the National Academy of Sciences of the United States of America, July 31, 2012, Vol.109(31), pp.12644-12649
description: Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and the consequences of aneuploidy on cell physiology remain poorly understood. We have performed a metaanalysis on gene expression data from aneuploid cells in diverse organisms, including yeast, plants, mice, and humans. We found highly related gene expression patterns that are conserved between species: genes that were involved in the response to stress were consistently upregulated, and genes associated with the cell cycle and cell proliferation were downregulated in aneuploid cells. Within species, different aneuploidies induced similar changes in gene expression, independent of the specific chromosomal aberrations. Taken together, our results demonstrate that aneuploidies of different chromosomes and in different organisms impact similar cellular pathways and cause a stereotypical anti-proliferative response that must be overcome before transformation. stress response | trisomy | chromosomal instability doi/10.1073/pnas.1209227109
language: eng
source:
identifier: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1209227109
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleTranscriptional consequences of aneuploidy.
creatorSheltzer, Jason M ; Torres, Eduardo M ; Dunham, Maitreya J ; Amon, Angelika
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identifierE-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1209227109
subjectAneuploidy–Genetics ; Animals–Metabolism ; Arabidopsis–Physiology ; Cell Line–Physiology ; Gene Expression Regulation, Fungal–Genetics ; Gene Expression Regulation, Plant–Metabolism ; Humans–Genetics ; Mice–Metabolism ; Saccharomyces Cerevisiae–Physiology ; Schizosaccharomyces–Physiology ; Species Specificity–Physiology ; Transcription, Genetic–Physiology
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descriptionAneuploidy, or an aberrant karyotype, results in developmental disabilities and has been implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and the consequences of aneuploidy on cell physiology remain poorly understood. We have performed a metaanalysis on gene expression data from aneuploid cells in diverse organisms, including yeast, plants, mice, and humans. We found highly related gene expression patterns that are conserved between species: genes that were involved in the response to stress were consistently upregulated, and genes associated with the cell cycle and cell proliferation were downregulated in aneuploid cells. Within species, different aneuploidies induced similar changes in gene expression, independent of the specific chromosomal aberrations. Taken together, our results demonstrate that aneuploidies of different chromosomes and in different organisms impact similar cellular pathways and cause a stereotypical anti-proliferative response that must be overcome before transformation. stress response | trisomy | chromosomal instability doi/10.1073/pnas.1209227109
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