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Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors.

BACKGROUNDThe H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODSA total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detail... Full description

Journal Title: The Journal of antimicrobial chemotherapy July 2012, Vol.67(7), pp.1739-1745
Main Author: Delgado-Rodríguez, Miguel
Other Authors: Castilla, Jesús , Godoy, Pere , Martín, Vicente , Soldevila, Nuria , Alonso, Jordi , Astray, Jenaro , Baricot, Maretva , Cantón, Rafael , Castro, Ady , Gónzález-Candelas, Fernando , Mayoral, José María
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1460-2091 ; DOI: 10.1093/jac/dks098
Link: http://search.proquest.com/docview/1031159154/?pq-origsite=primo
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title: Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors.
format: Article
creator:
  • Delgado-Rodríguez, Miguel
  • Castilla, Jesús
  • Godoy, Pere
  • Martín, Vicente
  • Soldevila, Nuria
  • Alonso, Jordi
  • Astray, Jenaro
  • Baricot, Maretva
  • Cantón, Rafael
  • Castro, Ady
  • Gónzález-Candelas, Fernando
  • Mayoral, José María
subjects:
  • Adolescent–Administration & Dosage
  • Adult–Statistics & Numerical Data
  • Aged–Genetics
  • Aged, 80 and Over–Isolation & Purification
  • Antiviral Agents–Complications
  • Child–Drug Therapy
  • Child, Preschool–Mortality
  • Critical Care–Virology
  • Female–Antagonists & Inhibitors
  • Hospitalization–Antagonists & Inhibitors
  • Humans–Antagonists & Inhibitors
  • Infant–Antagonists & Inhibitors
  • Infant, Newborn
ispartof: The Journal of antimicrobial chemotherapy, July 2012, Vol.67(7), pp.1739-1745
description: BACKGROUNDThe H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODSA total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. RESULTSThe mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR = 2.21, 95% CI = 1.21-4.02), corticosteroid...
language: eng
source:
identifier: E-ISSN: 1460-2091 ; DOI: 10.1093/jac/dks098
fulltext: fulltext
issn:
  • 14602091
  • 1460-2091
url: Link


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titlePrognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors.
creatorDelgado-Rodríguez, Miguel ; Castilla, Jesús ; Godoy, Pere ; Martín, Vicente ; Soldevila, Nuria ; Alonso, Jordi ; Astray, Jenaro ; Baricot, Maretva ; Cantón, Rafael ; Castro, Ady ; Gónzález-Candelas, Fernando ; Mayoral, José María
contributorAzor, E (correspondence author) ; Carrillo, J (record owner) ; Moyano, R ; Navarro, J A ; Vázquez, M ; Zafra, F ; Bueno, M A ; Gómez, M L ; Mariscal, M ; Martínez, B ; Quesada, J P ; Sillero, M ; Carnero, M ; Fernández-Crehuet, J ; Del Diego Salas, J ; Fuentes
ispartofThe Journal of antimicrobial chemotherapy, July 2012, Vol.67(7), pp.1739-1745
identifierE-ISSN: 1460-2091 ; DOI: 10.1093/jac/dks098
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descriptionBACKGROUNDThe H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODSA total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. RESULTSThe mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR = 2.21, 95% CI = 1.21-4.02), corticosteroid...
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8Cantón, Rafael
9Castro, Ady
10Gónzález-Candelas, Fernando
11Mayoral, José María
12Quintana, José María
13Pumarola, Tomás
14Tamames, Sonia
15Sáez, Marc
16Domínguez, Angela
titlePrognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors.
descriptionBACKGROUNDThe H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODSA total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. RESULTSThe mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR = 2.21, 95% CI = 1.21-4.02), corticosteroid...
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1Adult–Statistics & Numerical Data
2Aged–Genetics
3Aged, 80 and Over–Isolation & Purification
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6Child, Preschool–Mortality
7Critical Care–Virology
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8Mariscal, M
9Martínez, B
10Quesada, J P
11Sillero, M
12Carnero, M
13Fernández-Crehuet, J
14Del Diego Salas, J
15Fuentes, V
16Gallardo, V
17Pérez, E
18López, R
19Maldonado, J R
20Morillo, A
21Navarro, J M
22Pérez, M
23Oña, S
24Pérez, M J
25Ubago, M C
26Zarzuela, M
27Blanquer, J
28Morales, M
29Carriedo, D
30Díez, F
31Fernández, I
32Fernandez, S
33Sanz, M P
34Castrodeza, J J
35Pérez, A
36Ortiz de Lejarazu, R
37Ortiz, J
38Pueyo, A
39Viejo, J L
40Redondo, P
41Molina, A
42Agustí, A
43Torres, A
44Trilla, A
45Vilella, A
46Barbé, F
47Blanch, L
48Navarro, G
49Bonfill, X
50López-Contreras, J
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52Puig, M T
53Borràs, E
54Martínez, A
55Torner, N
56Bravo, C
57Moraga, F
58Caylà, J
59Calafell, F
60Tortajada, C
61Garcia, I
62Ruiz, J
63García, J J
64Garín, O
65Gea, J
66Horcajada, J P
67Hayes, N
68Rosell, A
69Álvarez, C
70Enríquez, M
71Pozo, F
72Baquero, F
73Galán, J C
74Robustillo, A
75Valdeón, M
76Córdoba, E
77Dominguez, F
78García, J
79Génova, R
80Gil, Elisa
81Jiménez, S
82Lopaz, M A
83López, J
84Martín, F
85Martínez, M L
86Ordobás, M
87Rodriguez, E
88Sánchez, S
89Valdés, C
90Paño, J R
91Romero, M
92Martinez, A
93Martínez, L
94Ruiz, M
95Fanlo, P
96Gil, F
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titlePrognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors.
authorDelgado-Rodríguez, Miguel ; Castilla, Jesús ; Godoy, Pere ; Martín, Vicente ; Soldevila, Nuria ; Alonso, Jordi ; Astray, Jenaro ; Baricot, Maretva ; Cantón, Rafael ; Castro, Ady ; Gónzález-Candelas, Fernando ; Mayoral, José María
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1Adult–Statistics & Numerical Data
2Aged–Genetics
3Aged, 80 and Over–Isolation & Purification
4Antiviral Agents–Complications
5Child–Drug Therapy
6Child, Preschool–Mortality
7Critical Care–Virology
8Female–Antagonists & Inhibitors
9Hospitalization–Antagonists & Inhibitors
10Humans–Antagonists & Inhibitors
11Infant–Antagonists & Inhibitors
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0Delgado-Rodríguez, Miguel
1Castilla, Jesús
2Godoy, Pere
3Martín, Vicente
4Soldevila, Nuria
5Alonso, Jordi
6Astray, Jenaro
7Baricot, Maretva
8Cantón, Rafael
9Castro, Ady
10Gónzález-Candelas, Fernando
11Mayoral, José María
12Quintana, José María
13Pumarola, Tomás
14Tamames, Sonia
15Sáez, Marc
16Domínguez, Angela
17Azor, E
18Carrillo, J
19Moyano, R
20Navarro, J A
21Vázquez, M
22Zafra, F
23Bueno, M A
24Gómez, M L
25Mariscal, M
26Martínez, B
27Quesada, J P
28Sillero, M
29Carnero, M
30Fernández-Crehuet, J
31Del Diego Salas, J
32Fuentes, V
33Gallardo, V
34Pérez, E
35López, R
36Maldonado, J R
37Morillo, A
38Navarro, J M
39Pérez, M
40Oña, S
41Pérez, M J
42Ubago, M C
43Zarzuela, M
44Blanquer, J
45Morales, M
46Carriedo, D
47Díez, F
48Fernández, I
49Fernandez, S
50Sanz, M P
51Castrodeza, J J
52Pérez, A
53Ortiz de Lejarazu, R
54Ortiz, J
55Pueyo, A
56Viejo, J L
57Redondo, P
58Molina, A
59Agustí, A
60Torres, A
61Trilla, A
62Vilella, A
63Barbé, F
64Blanch, L
65Navarro, G
66Bonfill, X
67López-Contreras, J
68Pomar, V
69Puig, M T
70Borràs, E
71Martínez, A
72Torner, N
73Bravo, C
74Moraga, F
75Caylà, J
76Calafell, F
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78Garcia, I
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81Garín, O
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83Horcajada, J P
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85Rosell, A
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88Pozo, F
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1Castilla, Jesús
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3Martín, Vicente
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7Baricot, Maretva
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9Castro, Ady
10Gónzález-Candelas, Fernando
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12Quintana, José María
13Pumarola, Tomás
14Tamames, Sonia
15Sáez, Marc
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1Carrillo, J
2Moyano, R
3Navarro, J A
4Vázquez, M
5Zafra, F
6Bueno, M A
7Gómez, M L
8Mariscal, M
9Martínez, B
10Quesada, J P
11Sillero, M
12Carnero, M
13Fernández-Crehuet, J
14del Diego Salas, J
15Fuentes, V
16Gallardo, V
17Pérez, E
18López, R
19Maldonado, J R
20Morillo, A
21Navarro, J M
22Pérez, M
23Oña, S
24Pérez, M J
25Ubago, M C
26Zarzuela, M
27Blanquer, J
28Morales, M
29Carriedo, D
30Díez, F
31Fernández, I
32Fernandez, S
33Sanz, M P
34Castrodeza, J J
35Pérez, A
36Ortiz de Lejarazu, R
37Ortiz, J
38Pueyo, A
39Viejo, J L
40Redondo, P
41Molina, A
42Agustí, A
43Torres, A
44Trilla, A
45Vilella, A
46Barbé, F
47Blanch, L
48Navarro, G
49Bonfill, X
50López-Contreras, J
51Pomar, V
52Puig, M T
53Borràs, E
54Martínez, A
55Torner, N
56Bravo, C
57Moraga, F
58Caylà, J
59Calafell, F
60Tortajada, C
61Garcia, I
62Ruiz, J
63García, J J
64Garín, O
65Gea, J
66Horcajada, J P
67Hayes, N
68Rosell, A
69Álvarez, C
70Enríquez, M
71Pozo, F
72Baquero, F
73Galán, J C
74Robustillo, A
75Valdeón, M
76Córdoba, E
77Dominguez, F
78García, J
79Génova, R
80Gil, Elisa
81Jiménez, S
82Lopaz, M A
83López, J
84Martín, F
85Martínez, M L
86Ordobás, M
87Rodriguez, E
88Sánchez, S
89Valdés, C
90Paño, J R
91Romero, M
92Martinez, A
93Martínez, L
94Ruiz, M
95Fanlo, P
96Gil, F
97Martínez-Artola, V
98Ursua, M E
99Sota, M
100...
atitlePrognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors.
jtitleThe Journal of antimicrobial chemotherapy
risdate20120701
volume67
issue7
spage1739
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pages1739-1745
eissn1460-2091
formatjournal
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abstractBACKGROUNDThe H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. METHODSA total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. RESULTSThe mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR = 2.21, 95% CI = 1.21-4.02), corticosteroid...
doi10.1093/jac/dks098
urlhttp://search.proquest.com/docview/1031159154/
issn03057453
date2012-07-01