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A novel nanoparticle delivery system for in vivo targeting of the sciatic nerve: impact on regeneration

Aim: Innovative solutions in the development of drug delivery systems targeting the nerve tissue are awaited. In this regard, a novel system for the delivery of drugs to the sciatic nerve was created using nanomedical principles. Materials & methods: Chitosan was the vehicle material used in the exp... Full description

Journal Title: Nanomedicine Aug 2012, Vol.7(8), pp.1167-80
Main Author: Gonçalves, Nádia Pereira
Other Authors: Oliveira, Hugo , Pêgo, Ana Paula , Saraiva, Maria João
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.11.188
Link: http://search.proquest.com/docview/1036964834/?pq-origsite=primo
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title: A novel nanoparticle delivery system for in vivo targeting of the sciatic nerve: impact on regeneration
format: Article
creator:
  • Gonçalves, Nádia Pereira
  • Oliveira, Hugo
  • Pêgo, Ana Paula
  • Saraiva, Maria João
subjects:
  • Animals–Chemistry
  • Chitosan–Methods
  • Drug Delivery Systems–Administration & Dosage
  • Heparin–Therapeutic Use
  • Heparin–Chemically Induced
  • Inflammation–Immunology
  • Inflammation–Administration & Dosage
  • Intercellular Signaling Peptides & Proteins–Therapeutic Use
  • Intercellular Signaling Peptides & Proteins–Chemistry
  • Mice–Drug Effects
  • Nanoparticles–Drug Effects
  • Nerve Regeneration–Immunology
  • Sciatic Nerve–Physiology
  • Sciatic Nerve–Physiology
  • Sciatic Nerve–Physiology
  • Swine
ispartof: Nanomedicine, Aug 2012, Vol.7(8), pp.1167-80
description: Aim: Innovative solutions in the development of drug delivery systems targeting the nerve tissue are awaited. In this regard, a novel system for the delivery of drugs to the sciatic nerve was created using nanomedical principles. Materials & methods: Chitosan was the vehicle material used in the experiment. Heparin bound to growth factors has been administered to enhance peripheral nerve regeneration, and since heparin possesses the appropriate charge to be able to form nanoparticles with chitosan, it appears to be a good candidate to base this new delivery system on. Results: Maximal absorption took place throughout the extracellular matrix at day 15. No major inflammatory response was observed, indicating that this is a safe and biocompatible system for drug delivery to nerves. Sensorimotor performance and nerve regeneration of mice receiving these nanoparticles were superior as compared with controls. Conclusion: Our work demonstrates a versatile nanoparticle delivery system that successfully...
language: eng
source:
identifier: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.11.188
fulltext: fulltext
issn:
  • 17435889
  • 1743-5889
  • 17486963
  • 1748-6963
url: Link


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titleA novel nanoparticle delivery system for in vivo targeting of the sciatic nerve: impact on regeneration
creatorGonçalves, Nádia Pereira ; Oliveira, Hugo ; Pêgo, Ana Paula ; Saraiva, Maria João
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subjectAnimals–Chemistry ; Chitosan–Methods ; Drug Delivery Systems–Administration & Dosage ; Heparin–Therapeutic Use ; Heparin–Chemically Induced ; Inflammation–Immunology ; Inflammation–Administration & Dosage ; Intercellular Signaling Peptides & Proteins–Therapeutic Use ; Intercellular Signaling Peptides & Proteins–Chemistry ; Mice–Drug Effects ; Nanoparticles–Drug Effects ; Nerve Regeneration–Immunology ; Sciatic Nerve–Physiology ; Sciatic Nerve–Physiology ; Sciatic Nerve–Physiology ; Swine
descriptionAim: Innovative solutions in the development of drug delivery systems targeting the nerve tissue are awaited. In this regard, a novel system for the delivery of drugs to the sciatic nerve was created using nanomedical principles. Materials & methods: Chitosan was the vehicle material used in the experiment. Heparin bound to growth factors has been administered to enhance peripheral nerve regeneration, and since heparin possesses the appropriate charge to be able to form nanoparticles with chitosan, it appears to be a good candidate to base this new delivery system on. Results: Maximal absorption took place throughout the extracellular matrix at day 15. No major inflammatory response was observed, indicating that this is a safe and biocompatible system for drug delivery to nerves. Sensorimotor performance and nerve regeneration of mice receiving these nanoparticles were superior as compared with controls. Conclusion: Our work demonstrates a versatile nanoparticle delivery system that successfully...
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titleA novel nanoparticle delivery system for in vivo targeting of the sciatic nerve: impact on regeneration
descriptionAim: Innovative solutions in the development of drug delivery systems targeting the nerve tissue are awaited. In this regard, a novel system for the delivery of drugs to the sciatic nerve was created using nanomedical principles. Materials & methods: Chitosan was the vehicle material used in the experiment. Heparin bound to growth factors has been administered to enhance peripheral nerve regeneration, and since heparin possesses the appropriate charge to be able to form nanoparticles with chitosan, it appears to be a good candidate to base this new delivery system on. Results: Maximal absorption took place throughout the extracellular matrix at day 15. No major inflammatory response was observed, indicating that this is a safe and biocompatible system for drug delivery to nerves. Sensorimotor performance and nerve regeneration of mice receiving these nanoparticles were superior as compared with controls. Conclusion: Our work demonstrates a versatile nanoparticle delivery system that successfully...
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abstractAim: Innovative solutions in the development of drug delivery systems targeting the nerve tissue are awaited. In this regard, a novel system for the delivery of drugs to the sciatic nerve was created using nanomedical principles. Materials & methods: Chitosan was the vehicle material used in the experiment. Heparin bound to growth factors has been administered to enhance peripheral nerve regeneration, and since heparin possesses the appropriate charge to be able to form nanoparticles with chitosan, it appears to be a good candidate to base this new delivery system on. Results: Maximal absorption took place throughout the extracellular matrix at day 15. No major inflammatory response was observed, indicating that this is a safe and biocompatible system for drug delivery to nerves. Sensorimotor performance and nerve regeneration of mice receiving these nanoparticles were superior as compared with controls. Conclusion: Our work demonstrates a versatile nanoparticle delivery system that successfully...
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pubFuture Medicine Ltd
doi10.2217/nnm.11.188
urlhttp://search.proquest.com/docview/1036964834/
date2012-08