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Surface modes and acoustic scattering of microspheres and ultrasound contrast agents.

Surface modes of spherical objects subject to ultrasound excitation have been recently proposed to explain experimental measurements of scattering from microspheres and ultrasound contrast agents (UCAs). In this work, the relationship between surface modes and resonance frequencies of microspheres a... Full description

Journal Title: The Journal of the Acoustical Society of America September 2012, Vol.132(3), pp.1820-1829
Main Author: Falou, Omar
Other Authors: Jafari Sojahrood, Amin , Kumaradas, J Carl , Kolios, Michael C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-8524 ; DOI: 10.1121/1.4740505
Link: http://search.proquest.com/docview/1040996321/?pq-origsite=primo
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recordid: proquest1040996321
title: Surface modes and acoustic scattering of microspheres and ultrasound contrast agents.
format: Article
creator:
  • Falou, Omar
  • Jafari Sojahrood, Amin
  • Kumaradas, J Carl
  • Kolios, Michael C
subjects:
  • Computer Simulation–Chemistry
  • Contrast Media–Chemistry
  • Elastic Modulus–Methods
  • Finite Element Analysis–Methods
  • Microspheres–Methods
  • Models, Theoretical–Methods
  • Numerical Analysis, Computer-Assisted–Methods
  • Polystyrenes–Methods
  • Pressure–Methods
  • Reproducibility of Results–Methods
  • Scattering, Radiation–Methods
  • Sound–Methods
  • Surface Properties–Methods
  • Time Factors–Methods
  • Ultrasonics–Methods
  • Ultrasonography–Methods
  • Vibration–Methods
  • Contrast Media
  • Polystyrenes
ispartof: The Journal of the Acoustical Society of America, September 2012, Vol.132(3), pp.1820-1829
description: Surface modes of spherical objects subject to ultrasound excitation have been recently proposed to explain experimental measurements of scattering from microspheres and ultrasound contrast agents (UCAs). In this work, the relationship between surface modes and resonance frequencies of microspheres and UCAs is investigated. A finite-element model, built upon the fundamentals of wave propagation and structural mechanics, was introduced and validated against analytical solutions (error
language: eng
source:
identifier: E-ISSN: 1520-8524 ; DOI: 10.1121/1.4740505
fulltext: fulltext
issn:
  • 15208524
  • 1520-8524
url: Link


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titleSurface modes and acoustic scattering of microspheres and ultrasound contrast agents.
creatorFalou, Omar ; Jafari Sojahrood, Amin ; Kumaradas, J Carl ; Kolios, Michael C
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identifierE-ISSN: 1520-8524 ; DOI: 10.1121/1.4740505
subjectComputer Simulation–Chemistry ; Contrast Media–Chemistry ; Elastic Modulus–Methods ; Finite Element Analysis–Methods ; Microspheres–Methods ; Models, Theoretical–Methods ; Numerical Analysis, Computer-Assisted–Methods ; Polystyrenes–Methods ; Pressure–Methods ; Reproducibility of Results–Methods ; Scattering, Radiation–Methods ; Sound–Methods ; Surface Properties–Methods ; Time Factors–Methods ; Ultrasonics–Methods ; Ultrasonography–Methods ; Vibration–Methods ; Contrast Media ; Polystyrenes
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descriptionSurface modes of spherical objects subject to ultrasound excitation have been recently proposed to explain experimental measurements of scattering from microspheres and ultrasound contrast agents (UCAs). In this work, the relationship between surface modes and resonance frequencies of microspheres and UCAs is investigated. A finite-element model, built upon the fundamentals of wave propagation and structural mechanics, was introduced and validated against analytical solutions (error <5%). Numerical results showed the existence of a systematic relationship between resonance frequencies and surface modes of a 30 μm microsphere driven at 1-70 MHz. On the contrary, for a 100 nm shelled, 4 μm diameter UCA, no clear relationship between the resonance frequencies and the surface modes was found in the frequency range examined. Instead, the UCA exhibited a collection of complex oscillations, which appear to be a combination of various surface modes and displacements. A study of the effects of varying the shell properties on the backscatter showed the presence of peaks in the backscatter of thick-shelled UCAs, which are not predicted by previous models. In summary, this work presents a systematic effort to examine scattering and surface modes from ultrasound contrast agents using finite-element models.
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