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Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane

Direct drug delivery to the cochlea is associated with the risk of irreversible damage to the ear. In this study, liposome and polymersome nanoparticles (NPs), both formed from amphiphilic molecules (lipids in liposomes and block copolymers in polymersomes), were tested as potential tools for drug d... Full description

Journal Title: Nanomedicine Sep 2012, Vol.7(9), pp.1339-54
Main Author: Buckiová, Daniela
Other Authors: Ranjan, Sanjeev , Newman, Tracey , Johnston, Alexander , Sood, Rohit , Kinnunen, Paavo Kj , Popelár, Jirí , Chumak, Tetyana , Syka, Josef
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.12.5
Link: http://search.proquest.com/docview/1041339836/?pq-origsite=primo
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recordid: proquest1041339836
title: Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane
format: Article
creator:
  • Buckiová, Daniela
  • Ranjan, Sanjeev
  • Newman, Tracey
  • Johnston, Alexander
  • Sood, Rohit
  • Kinnunen, Paavo Kj
  • Popelár, Jirí
  • Chumak, Tetyana
  • Syka, Josef
subjects:
  • Animals–Drug Effects
  • Apoptosis–Metabolism
  • Caspase 3–Drug Effects
  • Cochlea–Metabolism
  • Cochlea–Ultrastructure
  • Cochlea–Administration & Dosage
  • Cytotoxins–Pharmacology
  • Cytotoxins–Administration & Dosage
  • Disulfiram–Pharmacology
  • Disulfiram–Methods
  • Drug Delivery Systems–Analysis
  • Female–Analysis
  • Liposomes–Drug Effects
  • Male–Ultrastructure
  • Mice–Drug Effects
  • Nanoparticles–Metabolism
  • Organ of Corti–Ultrastructure
  • Organ of Corti
ispartof: Nanomedicine, Sep 2012, Vol.7(9), pp.1339-54
description: Direct drug delivery to the cochlea is associated with the risk of irreversible damage to the ear. In this study, liposome and polymersome nanoparticles (NPs), both formed from amphiphilic molecules (lipids in liposomes and block copolymers in polymersomes), were tested as potential tools for drug delivery...
language: eng
source:
identifier: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.12.5
fulltext: fulltext
issn:
  • 17435889
  • 1743-5889
  • 17486963
  • 1748-6963
url: Link


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titleMinimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane
creatorBuckiová, Daniela ; Ranjan, Sanjeev ; Newman, Tracey ; Johnston, Alexander ; Sood, Rohit ; Kinnunen, Paavo Kj ; Popelár, Jirí ; Chumak, Tetyana ; Syka, Josef
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subjectAnimals–Drug Effects ; Apoptosis–Metabolism ; Caspase 3–Drug Effects ; Cochlea–Metabolism ; Cochlea–Ultrastructure ; Cochlea–Administration & Dosage ; Cytotoxins–Pharmacology ; Cytotoxins–Administration & Dosage ; Disulfiram–Pharmacology ; Disulfiram–Methods ; Drug Delivery Systems–Analysis ; Female–Analysis ; Liposomes–Drug Effects ; Male–Ultrastructure ; Mice–Drug Effects ; Nanoparticles–Metabolism ; Organ of Corti–Ultrastructure ; Organ of Corti
descriptionDirect drug delivery to the cochlea is associated with the risk of irreversible damage to the ear. In this study, liposome and polymersome nanoparticles (NPs), both formed from amphiphilic molecules (lipids in liposomes and block copolymers in polymersomes), were tested as potential tools for drug delivery...
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titleMinimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane
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titleMinimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane
authorBuckiová, Daniela ; Ranjan, Sanjeev ; Newman, Tracey ; Johnston, Alexander ; Sood, Rohit ; Kinnunen, Paavo Kj ; Popelár, Jirí ; Chumak, Tetyana ; Syka, Josef
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abstractDirect drug delivery to the cochlea is associated with the risk of irreversible damage to the ear. In this study, liposome and polymersome nanoparticles (NPs), both formed from amphiphilic molecules (lipids in liposomes and block copolymers in polymersomes), were tested as potential tools for drug delivery...
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pubFuture Medicine Ltd
doi10.2217/nnm.12.5
urlhttp://search.proquest.com/docview/1041339836/
date2012-09-01