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TRP channel blamed for burning cold after a tropical fish meal.

Voets comments on a study by Vetter et al (2012) that reveals the key molecular players that underlie the altered temperature sensation associated with ciguatera. In particular, they show that ciguatoxins act on sensory neurons that express TRPA1, an ion channel implicated in the detection of noxiou... Full description

Journal Title: The EMBO journal October 3, 2012, Vol.31(19), pp.3785-3787
Main Author: Voets, Thomas
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1460-2075 ; DOI: 1460-2075 ; DOI: 10.1038/emboj.2012.255
Link: http://search.proquest.com/docview/1082409846/?pq-origsite=primo
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recordid: proquest1082409846
title: TRP channel blamed for burning cold after a tropical fish meal.
format: Article
creator:
  • Voets, Thomas
subjects:
  • Animals–Toxicity
  • Ciguatoxins–Chemically Induced
  • Male–Chemically Induced
  • Pain–Chemically Induced
  • Ciguatoxins
ispartof: The EMBO journal, October 3, 2012, Vol.31(19), pp.3785-3787
description: Voets comments on a study by Vetter et al (2012) that reveals the key molecular players that underlie the altered temperature sensation associated with ciguatera. In particular, they show that ciguatoxins act on sensory neurons that express TRPA1, an ion channel implicated in the detection of noxious cold. In addition to providing a molecular and cellular basis for ciguatera-associated cold allodynia, the study also further strengthens the theory that TRPA1 is a relevant cold sensor in vivo, which has been disputed in several studies.
language: eng
source:
identifier: E-ISSN: 1460-2075 ; DOI: 1460-2075 ; DOI: 10.1038/emboj.2012.255
fulltext: fulltext
issn:
  • 14602075
  • 1460-2075
url: Link


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descriptionVoets comments on a study by Vetter et al (2012) that reveals the key molecular players that underlie the altered temperature sensation associated with ciguatera. In particular, they show that ciguatoxins act on sensory neurons that express TRPA1, an ion channel implicated in the detection of noxious cold. In addition to providing a molecular and cellular basis for ciguatera-associated cold allodynia, the study also further strengthens the theory that TRPA1 is a relevant cold sensor in vivo, which has been disputed in several studies.
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