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A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk.

BACKGROUNDThe intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans. OBJECTIVEThe objective of the study was to examine the l... Full description

Journal Title: The Journal of clinical endocrinology and metabolism October 2012, Vol.97(10), pp.3792-3798
Main Author: Fernández-Real, José Manuel
Other Authors: Bulló, Mónica , Moreno-Navarrete, José Maria , Ricart, Wifredo , Ros, Emilio , Estruch, Ramon , Salas-Salvadó, Jordi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1945-7197 ; DOI: 1945-7197 ; DOI: 10.1210/jc.2012-2221
Link: http://search.proquest.com/docview/1095455774/?pq-origsite=primo
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title: A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk.
format: Article
creator:
  • Fernández-Real, José Manuel
  • Bulló, Mónica
  • Moreno-Navarrete, José Maria
  • Ricart, Wifredo
  • Ros, Emilio
  • Estruch, Ramon
  • Salas-Salvadó, Jordi
subjects:
  • Aged–Metabolism
  • Aged, 80 and Over–Blood
  • Aging–Epidemiology
  • Biomarkers–Metabolism
  • Cardiovascular Diseases–Blood
  • Collagen Type I–Physiology
  • Diet, Fat-Restricted–Blood
  • Diet, Mediterranean–Blood
  • Homeostasis–Diet Therapy
  • Humans–Epidemiology
  • Longitudinal Studies–Blood
  • Male–Administration & Dosage
  • Middle Aged–Administration & Dosage
  • Nuts–Administration & Dosage
  • Olive Oil–Administration & Dosage
  • Osteocalcin–Administration & Dosage
  • Osteoporosis–Administration & Dosage
  • Peptides–Administration & Dosage
  • Plant Oils–Administration & Dosage
  • Risk Factors–Administration & Dosage
  • Treatment Outcome–Administration & Dosage
  • Abridged
  • Biomarkers
  • Collagen Type I
  • Olive Oil
  • Peptides
  • Plant Oils
  • Collagen Type I Trimeric Cross-Linked Peptide
  • Osteocalcin
ispartof: The Journal of clinical endocrinology and metabolism, October 2012, Vol.97(10), pp.3792-3798
description: BACKGROUNDThe intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans. OBJECTIVEThe objective of the study was to examine the longitudinal effects of a low-fat control diet (n=34), a Mediterranean diet enriched with nuts (MedDiet+nuts, n=51), or a Mediterranean diet enriched with virgin olive oil (MedDiet+VOO, n=42) on circulating forms of OC and bone formation markers in elderly men at high cardiovascular risk. DESIGNLongitudinal associations between baseline and follow-up (2 yr) measurements of total OC, undercarboxylated osteocalcin, C-telopeptide of type I collagen, and procollagen I N-terminal propeptide (P1NP) concentrations were examined in 127 elderly men randomized to three healthy dietary interventions. RESULTSBaseline characteristics (age, body mass index, waist circumference, lipid profile, fasting insulin levels, and bone formation and resorption markers) were similar in all intervention groups. The total osteocalcin concentration increased robustly in the MedDiet+VOO group (P=0.007) in parallel to increased P1NP levels (P=0.01) and homeostasis model assessment-β-cell function (P=0.01) but not in subjects on the MedDiet+nuts (P=0.32) or after the control diet (P=0.74). Interestingly, the consumption of olives was associated positively with both baseline total osteocalcin (r=0.23, P=0.02) and the 2-yr osteocalcin concentrations (r=0.21, P=0.04) in the total cohort. CONCLUSIONSConsumption of a Mediterranean diet enriched with virgin olive oil for 2 years is associated with increased serum osteocalcin and P1NP concentrations, suggesting protective effects on bone.
language: eng
source:
identifier: E-ISSN: 1945-7197 ; DOI: 1945-7197 ; DOI: 10.1210/jc.2012-2221
fulltext: fulltext
issn:
  • 19457197
  • 1945-7197
url: Link


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titleA Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk.
creatorFernández-Real, José Manuel ; Bulló, Mónica ; Moreno-Navarrete, José Maria ; Ricart, Wifredo ; Ros, Emilio ; Estruch, Ramon ; Salas-Salvadó, Jordi
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descriptionBACKGROUNDThe intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans. OBJECTIVEThe objective of the study was to examine the longitudinal effects of a low-fat control diet (n=34), a Mediterranean diet enriched with nuts (MedDiet+nuts, n=51), or a Mediterranean diet enriched with virgin olive oil (MedDiet+VOO, n=42) on circulating forms of OC and bone formation markers in elderly men at high cardiovascular risk. DESIGNLongitudinal associations between baseline and follow-up (2 yr) measurements of total OC, undercarboxylated osteocalcin, C-telopeptide of type I collagen, and procollagen I N-terminal propeptide (P1NP) concentrations were examined in 127 elderly men randomized to three healthy dietary interventions. RESULTSBaseline characteristics (age, body mass index, waist circumference, lipid profile, fasting insulin levels, and bone formation and resorption markers) were similar in all intervention groups. The total osteocalcin concentration increased robustly in the MedDiet+VOO group (P=0.007) in parallel to increased P1NP levels (P=0.01) and homeostasis model assessment-β-cell function (P=0.01) but not in subjects on the MedDiet+nuts (P=0.32) or after the control diet (P=0.74). Interestingly, the consumption of olives was associated positively with both baseline total osteocalcin (r=0.23, P=0.02) and the 2-yr osteocalcin concentrations (r=0.21, P=0.04) in the total cohort. CONCLUSIONSConsumption of a Mediterranean diet enriched with virgin olive oil for 2 years is associated with increased serum osteocalcin and P1NP concentrations, suggesting protective effects on bone.
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titleA Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk.
descriptionBACKGROUNDThe intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans. OBJECTIVEThe objective of the study was to examine the longitudinal effects of a low-fat control diet (n=34), a Mediterranean diet enriched with nuts (MedDiet+nuts, n=51), or a Mediterranean diet enriched with virgin olive oil (MedDiet+VOO, n=42) on circulating forms of OC and bone formation markers in elderly men at high cardiovascular risk. DESIGNLongitudinal associations between baseline and follow-up (2 yr) measurements of total OC, undercarboxylated osteocalcin, C-telopeptide of type I collagen, and procollagen I N-terminal propeptide (P1NP) concentrations were examined in 127 elderly men randomized to three healthy dietary interventions. RESULTSBaseline characteristics (age, body mass index, waist circumference, lipid profile, fasting insulin levels, and bone formation and resorption markers) were similar in all intervention groups. The total osteocalcin concentration increased robustly in the MedDiet+VOO group (P=0.007) in parallel to increased P1NP levels (P=0.01) and homeostasis model assessment-β-cell function (P=0.01) but not in subjects on the MedDiet+nuts (P=0.32) or after the control diet (P=0.74). Interestingly, the consumption of olives was associated positively with both baseline total osteocalcin (r=0.23, P=0.02) and the 2-yr osteocalcin concentrations (r=0.21, P=0.04) in the total cohort. CONCLUSIONSConsumption of a Mediterranean diet enriched with virgin olive oil for 2 years is associated with increased serum osteocalcin and P1NP concentrations, suggesting protective effects on bone.
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10Longitudinal Studies–Blood
11Male–Administration & Dosage
12Middle Aged–Administration & Dosage
13Nuts–Administration & Dosage
14Olive Oil–Administration & Dosage
15Osteocalcin–Administration & Dosage
16Osteoporosis–Administration & Dosage
17Peptides–Administration & Dosage
18Plant Oils–Administration & Dosage
19Risk Factors–Administration & Dosage
20Treatment Outcome–Administration & Dosage
21Abridged
22Biomarkers
23Collagen Type I
24Olive Oil
25Peptides
26Plant Oils
27Collagen Type I Trimeric Cross-Linked Peptide
28Osteocalcin
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abstractBACKGROUNDThe intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans. OBJECTIVEThe objective of the study was to examine the longitudinal effects of a low-fat control diet (n=34), a Mediterranean diet enriched with nuts (MedDiet+nuts, n=51), or a Mediterranean diet enriched with virgin olive oil (MedDiet+VOO, n=42) on circulating forms of OC and bone formation markers in elderly men at high cardiovascular risk. DESIGNLongitudinal associations between baseline and follow-up (2 yr) measurements of total OC, undercarboxylated osteocalcin, C-telopeptide of type I collagen, and procollagen I N-terminal propeptide (P1NP) concentrations were examined in 127 elderly men randomized to three healthy dietary interventions. RESULTSBaseline characteristics (age, body mass index, waist circumference, lipid profile, fasting insulin levels, and bone formation and resorption markers) were similar in all intervention groups. The total osteocalcin concentration increased robustly in the MedDiet+VOO group (P=0.007) in parallel to increased P1NP levels (P=0.01) and homeostasis model assessment-β-cell function (P=0.01) but not in subjects on the MedDiet+nuts (P=0.32) or after the control diet (P=0.74). Interestingly, the consumption of olives was associated positively with both baseline total osteocalcin (r=0.23, P=0.02) and the 2-yr osteocalcin concentrations (r=0.21, P=0.04) in the total cohort. CONCLUSIONSConsumption of a Mediterranean diet enriched with virgin olive oil for 2 years is associated with increased serum osteocalcin and P1NP concentrations, suggesting protective effects on bone.
doi10.1210/jc.2012-2221
urlhttp://search.proquest.com/docview/1095455774/
issn0021972X
date2012-10-01