schliessen

Filtern

 

Bibliotheken

Periodic changes in fMRI connectivity.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.06.078 Byline: Daniel A. Handwerker, Vinai Roopchansingh, Javier Gonzalez-Castillo, Peter A. Bandettini Keywords: BOLD; fMRI; Posterior cingulate; Default mode; Spontaneous fluctuations; Restin... Full description

Journal Title: NeuroImage November 15, 2012, Vol.63(3), pp.1712-1719
Main Author: Handwerker, Daniel A
Other Authors: Roopchansingh, Vinai , Gonzalez-Castillo, Javier , Bandettini, Peter A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.06.078
Link: http://search.proquest.com/docview/1112340946/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1112340946
title: Periodic changes in fMRI connectivity.
format: Article
creator:
  • Handwerker, Daniel A
  • Roopchansingh, Vinai
  • Gonzalez-Castillo, Javier
  • Bandettini, Peter A
subjects:
  • Adult–Physiology
  • Brain–Physiology
  • Brain Mapping–Physiology
  • Female–Physiology
  • Humans–Physiology
  • Image Interpretation, Computer-Assisted–Physiology
  • Magnetic Resonance Imaging–Physiology
  • Male–Physiology
  • Neural Pathways–Physiology
  • Rest–Physiology
ispartof: NeuroImage, November 15, 2012, Vol.63(3), pp.1712-1719
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.06.078 Byline: Daniel A. Handwerker, Vinai Roopchansingh, Javier Gonzalez-Castillo, Peter A. Bandettini Keywords: BOLD; fMRI; Posterior cingulate; Default mode; Spontaneous fluctuations; Resting-state Abstract: The first two decades of brain research using fMRI have been dominated by studies that measure signal changes in response to a presented task. A rapidly increasing number of studies are showing that consistent activation maps appear by assessment of signal correlations during time periods in which the subjects were not directed to perform any specific task (i.e. "resting state correlations"). Even though neural interactions can happen on much shorter time scales, most "resting state" studies assess these temporal correlations over a period of about 5 to 10min. Here we investigate how these temporal correlations change on a shorter time scale. We examine changes in brain correlations to the posterior cingulate cortex (PCC) across a 10aminute scan. We show: (1) fMRI correlations fluctuate over time, (2) these fluctuations can be periodic, and (3) correlations between the PCC and other brain regions fluctuate at distinct frequencies. While the precise frequencies of correlation fluctuations vary across subjects and runs, it is still possible to parse brain regions and combinations of brain regions based on fluctuation frequency differences. To evaluate the potential biological significance of these empirical observations, we then use synthetic time series data with identical amplitude spectra, but randomized phase to show that similar effects can still appear even if the timing relationships between voxels are randomized. This implies that observed correlation fluctuations could occur between regions with distinct amplitude spectra, whether or not there are dynamic changes in neural connectivity between such regions. As more studies of brain connectivity dynamics appear, particularly studies using correlation as a key metric, it is vital to better distinguish true neural connectivity dynamics from connectivity fluctuations that are inherently part of this method. Our results also highlight the rich information in the power spectra of fMRI data that can be used to parse brain regions. Article History: Accepted 29 June 2012
language: eng
source:
identifier: E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.06.078
fulltext: fulltext
issn:
  • 10959572
  • 1095-9572
url: Link


@attributes
ID517684609
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1112340946
sourceidproquest
recordidTN_proquest1112340946
sourcesystemPC
pqid1112340946
galeid305349226
display
typearticle
titlePeriodic changes in fMRI connectivity.
creatorHandwerker, Daniel A ; Roopchansingh, Vinai ; Gonzalez-Castillo, Javier ; Bandettini, Peter A
contributorHandwerker, Daniel A (correspondence author) ; Handwerker, Daniel A (record owner)
ispartofNeuroImage, November 15, 2012, Vol.63(3), pp.1712-1719
identifierE-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.06.078
subjectAdult–Physiology ; Brain–Physiology ; Brain Mapping–Physiology ; Female–Physiology ; Humans–Physiology ; Image Interpretation, Computer-Assisted–Physiology ; Magnetic Resonance Imaging–Physiology ; Male–Physiology ; Neural Pathways–Physiology ; Rest–Physiology
languageeng
source
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2012.06.078 Byline: Daniel A. Handwerker, Vinai Roopchansingh, Javier Gonzalez-Castillo, Peter A. Bandettini Keywords: BOLD; fMRI; Posterior cingulate; Default mode; Spontaneous fluctuations; Resting-state Abstract: The first two decades of brain research using fMRI have been dominated by studies that measure signal changes in response to a presented task. A rapidly increasing number of studies are showing that consistent activation maps appear by assessment of signal correlations during time periods in which the subjects were not directed to perform any specific task (i.e. "resting state correlations"). Even though neural interactions can happen on much shorter time scales, most "resting state" studies assess these temporal correlations over a period of about 5 to 10min. Here we investigate how these temporal correlations change on a shorter time scale. We examine changes in brain correlations to the posterior cingulate cortex (PCC) across a 10aminute scan. We show: (1) fMRI correlations fluctuate over time, (2) these fluctuations can be periodic, and (3) correlations between the PCC and other brain regions fluctuate at distinct frequencies. While the precise frequencies of correlation fluctuations vary across subjects and runs, it is still possible to parse brain regions and combinations of brain regions based on fluctuation frequency differences. To evaluate the potential biological significance of these empirical observations, we then use synthetic time series data with identical amplitude spectra, but randomized phase to show that similar effects can still appear even if the timing relationships between voxels are randomized. This implies that observed correlation fluctuations could occur between regions with distinct amplitude spectra, whether or not there are dynamic changes in neural connectivity between such regions. As more studies of brain connectivity dynamics appear, particularly studies using correlation as a key metric, it is vital to better distinguish true neural connectivity dynamics from connectivity fluctuations that are inherently part of this method. Our results also highlight the rich information in the power spectra of fMRI data that can be used to parse brain regions. Article History: Accepted 29 June 2012
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1112340946/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Handwerker, Daniel A
1Roopchansingh, Vinai
2Gonzalez-Castillo, Javier
3Bandettini, Peter A
titlePeriodic changes in fMRI connectivity.
subject
0Adult–Physiology
1Brain–Physiology
2Brain Mapping–Physiology
3Female–Physiology
4Humans–Physiology
5Image Interpretation, Computer-Assisted–Physiology
6Magnetic Resonance Imaging–Physiology
7Male–Physiology
8Neural Pathways–Physiology
9Rest–Physiology
general
0English
110.1016/j.neuroimage.2012.06.078
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1112340946
issn
010959572
11095-9572
rsrctypearticle
creationdate2012
addtitleNeuroImage
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorHandwerker, Daniel A
startdate20121115
enddate20121115
citationpf 1712 pt 1719 vol 63 issue 3
lsr30VSR-Enriched:[issn, galeid, description, pqid]
sort
titlePeriodic changes in fMRI connectivity.
authorHandwerker, Daniel A ; Roopchansingh, Vinai ; Gonzalez-Castillo, Javier ; Bandettini, Peter A
creationdate20121115
lso0120121115
facets
frbrgroupid4362242434463066574
frbrtype5
newrecords20181218
languageeng
creationdate2012
topic
0Adult–Physiology
1Brain–Physiology
2Brain Mapping–Physiology
3Female–Physiology
4Humans–Physiology
5Image Interpretation, Computer-Assisted–Physiology
6Magnetic Resonance Imaging–Physiology
7Male–Physiology
8Neural Pathways–Physiology
9Rest–Physiology
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Handwerker, Daniel A
1Roopchansingh, Vinai
2Gonzalez-Castillo, Javier
3Bandettini, Peter A
jtitleNeuroImage
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Handwerker
1Roopchansingh
2Gonzalez-Castillo
3Bandettini
aufirst
0Daniel A
1Vinai
2Javier
3Peter A
au
0Handwerker, Daniel A
1Roopchansingh, Vinai
2Gonzalez-Castillo, Javier
3Bandettini, Peter A
addauHandwerker, Daniel A
atitlePeriodic changes in fMRI connectivity.
jtitleNeuroImage
risdate20121115
volume63
issue3
spage1712
epage1719
pages1712-1719
eissn1095-9572
formatjournal
genrearticle
ristypeJOUR
doi10.1016/j.neuroimage.2012.06.078
urlhttp://search.proquest.com/docview/1112340946/
issn10538119
date2012-11-15