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Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China.

Seventeen meticillin-resistant coagulase-negative staphylococci (MRCoNS), including ten Staphylococcus capitis, four Staphylococcus cohnii, two Staphylococcus haemolyticus and one Staphylococcus sciuri, and an Enterococcus faecium isolate with various levels of linezolid resistance were isolated fro... Full description

Journal Title: Journal of medical microbiology November 2012, Vol.61, pp.1568-1573
Main Author: Cai, Jia Chang
Other Authors: Hu, Yan Yan , Zhang, Rong , Zhou, Hong Wei , Chen, Gong-Xiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1473-5644 ; DOI: 10.1099/jmm.0.043729-0
Link: http://search.proquest.com/docview/1112345308/?pq-origsite=primo
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title: Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China.
format: Article
creator:
  • Cai, Jia Chang
  • Hu, Yan Yan
  • Zhang, Rong
  • Zhou, Hong Wei
  • Chen, Gong-Xiang
subjects:
  • Acetamides–Pharmacology
  • Adult–Pharmacology
  • Aged–Epidemiology
  • Aged, 80 and Over–Metabolism
  • Anti-Bacterial Agents–Drug Effects
  • China–Genetics
  • Coagulase–Epidemiology
  • Electrophoresis, Gel, Pulsed-Field–Microbiology
  • Enterococcus Faecium–Drug Effects
  • Female–Enzymology
  • Gram-Positive Bacterial Infections–Pharmacology
  • Humans–Epidemiology
  • Intensive Care Units–Microbiology
  • Linezolid–Drug Effects
  • Male–Enzymology
  • Methicillin-Resistant Staphylococcus Aureus–Genetics
  • Middle Aged–Genetics
  • Oxazolidinones–Genetics
  • Staphylococcal Infections–Genetics
  • Staphylococcus–Genetics
  • Acetamides
  • Anti-Bacterial Agents
  • Coagulase
  • Oxazolidinones
  • Linezolid
ispartof: Journal of medical microbiology, November 2012, Vol.61, pp.1568-1573
description: Seventeen meticillin-resistant coagulase-negative staphylococci (MRCoNS), including ten Staphylococcus capitis, four Staphylococcus cohnii, two Staphylococcus haemolyticus and one Staphylococcus sciuri, and an Enterococcus faecium isolate with various levels of linezolid resistance were isolated from intensive care units in a Chinese hospital. PFGE indicated that the four S. cohnii isolates belonged to a clonal strain, and that nine of the S. capitis isolates were indistinguishable (clone A1) and the other one was closely related (clone A2). A G2576T mutation was identified in domain V of the 23S rRNA gene in the E. faecium isolate. Besides the G2576T mutation, a novel C2104T mutation was detected in the nine clone A1 S. capitis isolates. The cfr gene was detected in all the staphylococci except an S. sciuri isolate, whose 23S rRNA gene contained the G2576T mutation. There was a clonal dissemination of linezolid-resistant MRCoNS in intensive care units of our hospital, and this is the first report, to our knowledge, of linezolid-resistant staphylococci and enterococci in China.
language: eng
source:
identifier: E-ISSN: 1473-5644 ; DOI: 10.1099/jmm.0.043729-0
fulltext: fulltext
issn:
  • 14735644
  • 1473-5644
url: Link


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titleLinezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China.
creatorCai, Jia Chang ; Hu, Yan Yan ; Zhang, Rong ; Zhou, Hong Wei ; Chen, Gong-Xiang
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ispartofJournal of medical microbiology, November 2012, Vol.61, pp.1568-1573
identifierE-ISSN: 1473-5644 ; DOI: 10.1099/jmm.0.043729-0
subjectAcetamides–Pharmacology ; Adult–Pharmacology ; Aged–Epidemiology ; Aged, 80 and Over–Metabolism ; Anti-Bacterial Agents–Drug Effects ; China–Genetics ; Coagulase–Epidemiology ; Electrophoresis, Gel, Pulsed-Field–Microbiology ; Enterococcus Faecium–Drug Effects ; Female–Enzymology ; Gram-Positive Bacterial Infections–Pharmacology ; Humans–Epidemiology ; Intensive Care Units–Microbiology ; Linezolid–Drug Effects ; Male–Enzymology ; Methicillin-Resistant Staphylococcus Aureus–Genetics ; Middle Aged–Genetics ; Oxazolidinones–Genetics ; Staphylococcal Infections–Genetics ; Staphylococcus–Genetics ; Acetamides ; Anti-Bacterial Agents ; Coagulase ; Oxazolidinones ; Linezolid
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descriptionSeventeen meticillin-resistant coagulase-negative staphylococci (MRCoNS), including ten Staphylococcus capitis, four Staphylococcus cohnii, two Staphylococcus haemolyticus and one Staphylococcus sciuri, and an Enterococcus faecium isolate with various levels of linezolid resistance were isolated from intensive care units in a Chinese hospital. PFGE indicated that the four S. cohnii isolates belonged to a clonal strain, and that nine of the S. capitis isolates were indistinguishable (clone A1) and the other one was closely related (clone A2). A G2576T mutation was identified in domain V of the 23S rRNA gene in the E. faecium isolate. Besides the G2576T mutation, a novel C2104T mutation was detected in the nine clone A1 S. capitis isolates. The cfr gene was detected in all the staphylococci except an S. sciuri isolate, whose 23S rRNA gene contained the G2576T mutation. There was a clonal dissemination of linezolid-resistant MRCoNS in intensive care units of our hospital, and this is the first report, to our knowledge, of linezolid-resistant staphylococci and enterococci in China.
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