schliessen

Filtern

 

Bibliotheken

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.

CD8 super( +) cytotoxic T cells are critical for viral clearance from the lungs upon influenza virus infection. The contribution of antigen cross-presentation by DCs to the induction of anti-viral cytotoxic T cells remains controversial. Here, we used a recombinant influenza virus expressing a nonst... Full description

Journal Title: The Journal of clinical investigation November 2012, Vol.122(11), pp.4037-4047
Main Author: Helft, Julie
Other Authors: Manicassamy, Balaji , Guermonprez, Pierre , Hashimoto, Daigo , Silvin, Aymeric , Agudo, Judith , Brown, Brian D , Schmolke, Mirco , Miller, Jennifer C , Leboeuf, Marylene , Murphy, Kenneth M , García-Sastre, Adolfo , Merad, Miriam
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1558-8238 ; DOI: 10.1172/JCI60659
Link: http://search.proquest.com/docview/1126580275/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1126580275
title: Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.
format: Article
creator:
  • Helft, Julie
  • Manicassamy, Balaji
  • Guermonprez, Pierre
  • Hashimoto, Daigo
  • Silvin, Aymeric
  • Agudo, Judith
  • Brown, Brian D
  • Schmolke, Mirco
  • Miller, Jennifer C
  • Leboeuf, Marylene
  • Murphy, Kenneth M
  • García-Sastre, Adolfo
  • Merad, Miriam
subjects:
  • Animals–Genetics
  • Antigen Presentation–Immunology
  • Antigens, CD–Immunology
  • Antigens, Viral–Pathology
  • Cd8-Positive T-Lymphocytes–Immunology
  • Cell Line–Pathology
  • Dendritic Cells–Genetics
  • Dogs–Immunology
  • Green Fluorescent Proteins–Genetics
  • Influenza A Virus–Immunology
  • Integrin Alpha Chains–Genetics
  • Interferon Type I–Immunology
  • Lung–Immunology
  • Mice–Pathology
  • Orthomyxoviridae Infections–Virology
  • Receptor, Interferon Alpha-Beta–Genetics
  • Recombinant Fusion Proteins–Immunology
  • Signal Transduction–Prevention & Control
  • Viral Nonstructural Proteins–Genetics
  • Viral Nonstructural Proteins–Immunology
  • Viral Nonstructural Proteins–Genetics
  • Viral Nonstructural Proteins–Immunology
  • Viral Nonstructural Proteins–Genetics
  • Viral Nonstructural Proteins–Immunology
  • Viral Nonstructural Proteins–Genetics
  • Viral Nonstructural Proteins–Immunology
  • Abridged
  • Antigens, CD
  • Antigens, Viral
  • Ins1 Protein, Influenza Virus
  • Integrin Alpha Chains
  • Interferon Type I
  • Recombinant Fusion Proteins
  • Viral Nonstructural Proteins
  • Alpha E Integrins
  • Green Fluorescent Proteins
  • Receptor, Interferon Alpha-Beta
ispartof: The Journal of clinical investigation, November 2012, Vol.122(11), pp.4037-4047
description: CD8 super( +) cytotoxic T cells are critical for viral clearance from the lungs upon influenza virus infection. The contribution of antigen cross-presentation by DCs to the induction of anti-viral cytotoxic T cells remains controversial. Here, we used a recombinant influenza virus expressing a nonstructural 1-GFP (NS1-GFP) reporter gene to visualize the route of antigen presentation by lung DCs upon viral infection in mice. We found that lung CD103 super( +) DCs were the only subset of cells that carried intact GFP protein to the draining LNs. Strikingly, lung migratory CD103 super( +) DCs were not productively infected by influenza virus and thus were able to induce virus-specific CD8 super( +) T cells through the cross-presentation of antigens from virally infected cells. We also observed that CD103 super( +) DC resistance to infection correlates with an increased anti-viral state in these cells that is dependent on the expression of type I IFN receptor. These results show that efficient cross-priming by migratory lung DCs is coupled to the acquisition of an anti-viral status, which is dependent on the type I IFN signaling pathway.
language: eng
source:
identifier: E-ISSN: 1558-8238 ; DOI: 10.1172/JCI60659
fulltext: fulltext
issn:
  • 15588238
  • 1558-8238
url: Link


@attributes
ID640737924
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1126580275
sourceidproquest
recordidTN_proquest1126580275
sourcesystemPC
pqid1126580275
galeid309342774
display
typearticle
titleCross-presenting CD103+ dendritic cells are protected from influenza virus infection.
creatorHelft, Julie ; Manicassamy, Balaji ; Guermonprez, Pierre ; Hashimoto, Daigo ; Silvin, Aymeric ; Agudo, Judith ; Brown, Brian D ; Schmolke, Mirco ; Miller, Jennifer C ; Leboeuf, Marylene ; Murphy, Kenneth M ; García-Sastre, Adolfo ; Merad, Miriam
contributorHelft, Julie (correspondence author) ; Helft, Julie (record owner)
ispartofThe Journal of clinical investigation, November 2012, Vol.122(11), pp.4037-4047
identifierE-ISSN: 1558-8238 ; DOI: 10.1172/JCI60659
subjectAnimals–Genetics ; Antigen Presentation–Immunology ; Antigens, CD–Immunology ; Antigens, Viral–Pathology ; Cd8-Positive T-Lymphocytes–Immunology ; Cell Line–Pathology ; Dendritic Cells–Genetics ; Dogs–Immunology ; Green Fluorescent Proteins–Genetics ; Influenza A Virus–Immunology ; Integrin Alpha Chains–Genetics ; Interferon Type I–Immunology ; Lung–Immunology ; Mice–Pathology ; Orthomyxoviridae Infections–Virology ; Receptor, Interferon Alpha-Beta–Genetics ; Recombinant Fusion Proteins–Immunology ; Signal Transduction–Prevention & Control ; Viral Nonstructural Proteins–Genetics ; Viral Nonstructural Proteins–Immunology ; Viral Nonstructural Proteins–Genetics ; Viral Nonstructural Proteins–Immunology ; Viral Nonstructural Proteins–Genetics ; Viral Nonstructural Proteins–Immunology ; Viral Nonstructural Proteins–Genetics ; Viral Nonstructural Proteins–Immunology ; Abridged ; Antigens, CD ; Antigens, Viral ; Ins1 Protein, Influenza Virus ; Integrin Alpha Chains ; Interferon Type I ; Recombinant Fusion Proteins ; Viral Nonstructural Proteins ; Alpha E Integrins ; Green Fluorescent Proteins ; Receptor, Interferon Alpha-Beta
languageeng
source
descriptionCD8 super( +) cytotoxic T cells are critical for viral clearance from the lungs upon influenza virus infection. The contribution of antigen cross-presentation by DCs to the induction of anti-viral cytotoxic T cells remains controversial. Here, we used a recombinant influenza virus expressing a nonstructural 1-GFP (NS1-GFP) reporter gene to visualize the route of antigen presentation by lung DCs upon viral infection in mice. We found that lung CD103 super( +) DCs were the only subset of cells that carried intact GFP protein to the draining LNs. Strikingly, lung migratory CD103 super( +) DCs were not productively infected by influenza virus and thus were able to induce virus-specific CD8 super( +) T cells through the cross-presentation of antigens from virally infected cells. We also observed that CD103 super( +) DC resistance to infection correlates with an increased anti-viral state in these cells that is dependent on the expression of type I IFN receptor. These results show that efficient cross-priming by migratory lung DCs is coupled to the acquisition of an anti-viral status, which is dependent on the type I IFN signaling pathway.
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1126580275/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Helft, Julie
1Manicassamy, Balaji
2Guermonprez, Pierre
3Hashimoto, Daigo
4Silvin, Aymeric
5Agudo, Judith
6Brown, Brian D
7Schmolke, Mirco
8Miller, Jennifer C
9Leboeuf, Marylene
10Murphy, Kenneth M
11García-Sastre, Adolfo
12Merad, Miriam
titleCross-presenting CD103+ dendritic cells are protected from influenza virus infection.
subject
0Animals–Genetics
1Antigen Presentation–Immunology
2Antigens, CD–Immunology
3Antigens, Viral–Pathology
4Cd8-Positive T-Lymphocytes–Immunology
5Cell Line–Pathology
6Dendritic Cells–Genetics
7Dogs–Immunology
8Green Fluorescent Proteins–Genetics ;...
general
0English
110.1172/JCI60659
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1126580275
issn
015588238
11558-8238
rsrctypearticle
creationdate2012
addtitleThe Journal of clinical investigation
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorHelft, Julie
startdate20121101
enddate20121101
citationpf 4037 pt 4047 vol 122 issue 11
lsr30VSR-Enriched:[description, issn, galeid, pqid]
sort
titleCross-presenting CD103+ dendritic cells are protected from influenza virus infection.
authorHelft, Julie ; Manicassamy, Balaji ; Guermonprez, Pierre ; Hashimoto, Daigo ; Silvin, Aymeric ; Agudo, Judith ; Brown, Brian D ; Schmolke, Mirco ; Miller, Jennifer C ; Leboeuf, Marylene ; Murphy, Kenneth M ; García-Sastre, Adolfo ; Merad, Miriam
creationdate20121101
lso0120121101
facets
frbrgroupid8142889699649383450
frbrtype5
newrecords20181218
languageeng
creationdate2012
topic
0Animals–Genetics
1Antigen Presentation–Immunology
2Antigens, CD–Immunology
3Antigens, Viral–Pathology
4Cd8-Positive T-Lymphocytes–Immunology
5Cell Line–Pathology
6Dendritic Cells–Genetics
7Dogs–Immunology
8Green Fluorescent Proteins–Genetics ;...
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Helft, Julie
1Manicassamy, Balaji
2Guermonprez, Pierre
3Hashimoto, Daigo
4Silvin, Aymeric
5Agudo, Judith
6Brown, Brian D
7Schmolke, Mirco
8Miller, Jennifer C
9Leboeuf, Marylene
10Murphy, Kenneth M
11García-Sastre, Adolfo
12Merad, Miriam
jtitleJournal of clinical investigation
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Helft
1Manicassamy
2Guermonprez
3Hashimoto
4Silvin
5Agudo
6Brown
7Schmolke
8Miller
9Leboeuf
10Murphy
11García-Sastre
12Merad
aufirst
0Julie
1Balaji
2Pierre
3Daigo
4Aymeric
5Judith
6Brian D
7Mirco
8Jennifer C
9Marylene
10Kenneth M
11Adolfo
12Miriam
au
0Helft, Julie
1Manicassamy, Balaji
2Guermonprez, Pierre
3Hashimoto, Daigo
4Silvin, Aymeric
5Agudo, Judith
6Brown, Brian D
7Schmolke, Mirco
8Miller, Jennifer C
9Leboeuf, Marylene
10Murphy, Kenneth M
11García-Sastre, Adolfo
12Merad, Miriam
addauHelft, Julie
atitleCross-presenting CD103+ dendritic cells are protected from influenza virus infection.
jtitleThe Journal of clinical investigation
risdate20121101
volume122
issue11
spage4037
epage4047
pages4037-4047
eissn1558-8238
formatjournal
genrearticle
ristypeJOUR
doi10.1172/JCI60659
urlhttp://search.proquest.com/docview/1126580275/
issn00219738
date2012-11-01