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The role of WDR5 in silencing human fetal globin gene expression.

BACKGROUNDHistone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in human globin gene regulation has not yet been e... Full description

Journal Title: Haematologica November 2012, Vol.97(11), pp.1632-1640
Main Author: Xu, Zhen
Other Authors: He, Yinghong , Ju, Junyi , Rank, Gerhard , Cerruti, Loretta , Ma, Chi , Simpson, Richard J , Moritz, Robert L , Jane, Stephen M , Zhao, Quan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1592-8721 ; DOI: 10.3324/haematol.2012.061937
Link: http://search.proquest.com/docview/1139619325/?pq-origsite=primo
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recordid: proquest1139619325
title: The role of WDR5 in silencing human fetal globin gene expression.
format: Article
creator:
  • Xu, Zhen
  • He, Yinghong
  • Ju, Junyi
  • Rank, Gerhard
  • Cerruti, Loretta
  • Ma, Chi
  • Simpson, Richard J
  • Moritz, Robert L
  • Jane, Stephen M
  • Zhao, Quan
subjects:
  • Erythroid Precursor Cells–Cytology
  • Female–Metabolism
  • Fetal Globulins–Biosynthesis
  • Gene Knockdown Techniques–Genetics
  • Gene Silencing–Physiology
  • Histone Deacetylase 1–Genetics
  • Histone-Lysine N-Methyltransferase–Metabolism
  • Histones–Genetics
  • Homeodomain Proteins–Metabolism
  • Humans–Genetics
  • K562 Cells–Metabolism
  • Male–Genetics
  • Methylation–Metabolism
  • Models, Biological–Physiology
  • Promoter Regions, Genetic–Genetics
  • Protein-Arginine N-Methyltransferases–Metabolism
  • Receptors, Cytoplasmic and Nuclear–Genetics
  • Tumor Suppressor Proteins–Metabolism
  • Tumor Suppressor Proteins–Genetics
  • Tumor Suppressor Proteins–Metabolism
  • Fetal Globulins
  • Histones
  • Homeodomain Proteins
  • Ing2 Protein, Human
  • Receptors, Cytoplasmic and Nuclear
  • Tumor Suppressor Proteins
  • Wdr5 Protein, Human
  • Prmt5 Protein, Human
  • Protein-Arginine N-Methyltransferases
  • Histone-Lysine N-Methyltransferase
  • Hdac1 Protein, Human
  • Histone Deacetylase 1
ispartof: Haematologica, November 2012, Vol.97(11), pp.1632-1640
description: BACKGROUNDHistone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in human globin gene regulation has not yet been established....
language: eng
source:
identifier: E-ISSN: 1592-8721 ; DOI: 10.3324/haematol.2012.061937
fulltext: fulltext
issn:
  • 15928721
  • 1592-8721
url: Link


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titleThe role of WDR5 in silencing human fetal globin gene expression.
creatorXu, Zhen ; He, Yinghong ; Ju, Junyi ; Rank, Gerhard ; Cerruti, Loretta ; Ma, Chi ; Simpson, Richard J ; Moritz, Robert L ; Jane, Stephen M ; Zhao, Quan
contributorXu, Zhen (correspondence author) ; Xu, Zhen (record owner)
ispartofHaematologica, November 2012, Vol.97(11), pp.1632-1640
identifierE-ISSN: 1592-8721 ; DOI: 10.3324/haematol.2012.061937
subjectErythroid Precursor Cells–Cytology ; Female–Metabolism ; Fetal Globulins–Biosynthesis ; Gene Knockdown Techniques–Genetics ; Gene Silencing–Physiology ; Histone Deacetylase 1–Genetics ; Histone-Lysine N-Methyltransferase–Metabolism ; Histones–Genetics ; Homeodomain Proteins–Metabolism ; Humans–Genetics ; K562 Cells–Metabolism ; Male–Genetics ; Methylation–Metabolism ; Models, Biological–Physiology ; Promoter Regions, Genetic–Genetics ; Protein-Arginine N-Methyltransferases–Metabolism ; Receptors, Cytoplasmic and Nuclear–Genetics ; Tumor Suppressor Proteins–Metabolism ; Tumor Suppressor Proteins–Genetics ; Tumor Suppressor Proteins–Metabolism ; Fetal Globulins ; Histones ; Homeodomain Proteins ; Ing2 Protein, Human ; Receptors, Cytoplasmic and Nuclear ; Tumor Suppressor Proteins ; Wdr5 Protein, Human ; Prmt5 Protein, Human ; Protein-Arginine N-Methyltransferases ; Histone-Lysine N-Methyltransferase ; Hdac1 Protein, Human ; Histone Deacetylase 1
descriptionBACKGROUNDHistone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in human globin gene regulation has not yet been established....
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titleThe role of WDR5 in silencing human fetal globin gene expression.
descriptionBACKGROUNDHistone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in human globin gene regulation has not yet been established....
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abstractBACKGROUNDHistone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in human globin gene regulation has not yet been established....
doi10.3324/haematol.2012.061937
urlhttp://search.proquest.com/docview/1139619325/
issn03906078
date2012-11-01