schliessen

Filtern

 

Bibliotheken

Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low

Doc number: 137 Abstract Background: Although the Fat Mass and Obesity (FTO ) and Melanocortin-4 Receptor (MC4R ) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in w... Full description

Journal Title: Cardiovascular Diabetology 2012, Vol.11, p.137
Main Author: Ortega-Azorín, Carolina
Other Authors: Sorlí, Jose , Asensio, Eva , Coltell, Oscar , Martínez-González, Miguel , Salas-Salvadó, Jordi , Covas, Maria-Isabel , Arós, Fernando , Lapetra, José , Serra-Majem, Lluís , Gómez-Gracia
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 14752840 ; DOI: 10.1186/1475-2840-11-137
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1151091819
title: Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
format: Article
creator:
  • Ortega-Azorín, Carolina
  • Sorlí, Jose
  • Asensio, Eva
  • Coltell, Oscar
  • Martínez-González, Miguel
  • Salas-Salvadó, Jordi
  • Covas, Maria-Isabel
  • Arós, Fernando
  • Lapetra, José
  • Serra-Majem, Lluís
  • Gómez-Gracia
subjects:
  • Aged–Metabolism
  • Aged, 80 & Over–Blood
  • Blood Glucose–Diet Therapy
  • Body Mass Index–Genetics
  • Case-Control Studies–Physiopathology
  • Chi-Square Distribution–Blood
  • Diabetes Mellitus, Type 2–Genetics
  • Diabetes Mellitus, Type 2–Genetics
  • Diabetes Mellitus, Type 2–Genetics
  • Diabetes Mellitus, Type 2–Genetics
  • Diet, Mediterranean–Genetics
  • Fasting–Genetics
  • Female–Genetics
  • Gene Frequency–Genetics
  • Gene-Environment Interaction–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Humans–Genetics
  • Linear Models–Genetics
  • Logistic Models
ispartof: Cardiovascular Diabetology, 2012, Vol.11, p.137
description: Doc number: 137 Abstract Background: Although the Fat Mass and Obesity (FTO ) and Melanocortin-4 Receptor (MC4R ) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). Methods: Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes cases and 3,622 non-diabetic subjects) with no differences in BMI. Diet was assessed by validated questionnaires. FTO -rs9939609 and MC4R -rs17782313 were determined. An aggregate genetic score was calculated to test additive effects. Gene-diet interactions were analyzed. Results:...
language: eng
source:
identifier: E-ISSN: 14752840 ; DOI: 10.1186/1475-2840-11-137
fulltext: fulltext_linktorsrc
issn:
  • 14752840
  • 1475-2840
url: Link


@attributes
ID350350582
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1151091819
sourceidproquest
recordidTN_proquest1151091819
sourcesystemPC
pqid1151091819
display
typearticle
titleAssociations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
creatorOrtega-Azorín, Carolina ; Sorlí, Jose ; Asensio, Eva ; Coltell, Oscar ; Martínez-González, Miguel ; Salas-Salvadó, Jordi ; Covas, Maria-Isabel ; Arós, Fernando ; Lapetra, José ; Serra-Majem, Lluís ; Gómez-Gracia
ispartofCardiovascular Diabetology, 2012, Vol.11, p.137
identifierE-ISSN: 14752840 ; DOI: 10.1186/1475-2840-11-137
subjectAged–Metabolism ; Aged, 80 & Over–Blood ; Blood Glucose–Diet Therapy ; Body Mass Index–Genetics ; Case-Control Studies–Physiopathology ; Chi-Square Distribution–Blood ; Diabetes Mellitus, Type 2–Genetics ; Diabetes Mellitus, Type 2–Genetics ; Diabetes Mellitus, Type 2–Genetics ; Diabetes Mellitus, Type 2–Genetics ; Diet, Mediterranean–Genetics ; Fasting–Genetics ; Female–Genetics ; Gene Frequency–Genetics ; Gene-Environment Interaction–Genetics ; Genetic Predisposition to Disease–Genetics ; Humans–Genetics ; Linear Models–Genetics ; Logistic Models
descriptionDoc number: 137 Abstract Background: Although the Fat Mass and Obesity (FTO ) and Melanocortin-4 Receptor (MC4R ) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). Methods: Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes cases and 3,622 non-diabetic subjects) with no differences in BMI. Diet was assessed by validated questionnaires. FTO -rs9939609 and MC4R -rs17782313 were determined. An aggregate genetic score was calculated to test additive effects. Gene-diet interactions were analyzed. Results:...
languageeng
source
version3
oafree_for_read
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
linktorsrc$$Uhttp://search.proquest.com/docview/1151091819/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Ortega-Azorín, Carolina
1Sorlí, Jose
2Asensio, Eva
3Coltell, Oscar
4Martínez-González, Miguel
5Salas-Salvadó, Jordi
6Covas, Maria-Isabel
7Arós, Fernando
8Lapetra, José
9Serra-Majem, Lluís
10Gómez-Gracia, Enrique
11Fiol, Miquel
12Sáez-Tormo, Guillermo
13Pintó, Xavier
14Muñoz, Miguel
15Ros, Emilio
16Ordovás, Jose
17Estruch, Ramon
18Corella, Dolores
titleAssociations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
descriptionDoc number: 137 Abstract Background: Although the Fat Mass and Obesity (FTO ) and Melanocortin-4 Receptor (MC4R ) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). Methods: Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes cases and 3,622 non-diabetic subjects) with no differences in BMI. Diet was assessed by validated questionnaires. FTO -rs9939609 and MC4R -rs17782313 were determined. An aggregate genetic score was calculated to test additive effects. Gene-diet interactions were analyzed. Results:...
subject
0Aged–Metabolism
1Aged, 80 & Over–Blood
2Blood Glucose–Diet Therapy
3Body Mass Index–Genetics
4Case-Control Studies–Physiopathology
5Chi-Square Distribution–Blood
6Diabetes Mellitus, Type 2–Genetics
7Diet, Mediterranean–Genetics
8Fasting–Genetics
9Female–Genetics
10Gene Frequency–Genetics
11Gene-Environment Interaction–Genetics
12Genetic Predisposition to Disease–Genetics
13Humans–Genetics
14Linear Models–Genetics
15Logistic Models
general
0English
1BioMed Central
210.1186/1475-2840-11-137
3Medical Database
4Health & Medical Collection (Alumni edition)
5Medical Database (Alumni edition)
6Health & Medical Collection
7Publicly Available Content Database
8Engineering Research Database
9Technology Research Database
10ProQuest Biological Science Collection
11ProQuest Central
12ProQuest Engineering Collection
13ProQuest Environmental Science Collection
14ProQuest Hospital Collection
15ProQuest Natural Science Collection
16ProQuest Technology Collection
17Hospital Premium Collection (Alumni edition)
18ProQuest SciTech Collection
19ProQuest Health & Medical Complete
20ProQuest Medical Library
21Agricultural & Environmental Science Database
22Biological Science Database
23Materials Science & Engineering Database
24Natural Science Collection
25ProQuest Central (new)
26ProQuest Central Korea
27SciTech Premium Collection
28Technology Collection
29Health Research Premium Collection
30Health Research Premium Collection (Alumni edition)
31ProQuest Central Essentials
32ProQuest Central China
33ProQuest One Academic
34Environmental Science Index (ProQuest)
35Biological Science Index (ProQuest)
36Engineering Index (ProQuest)
37Environmental Science Collection (ProQuest)
38Engineering Collection (ProQuest)
sourceidproquest
recordidproquest1151091819
issn
014752840
11475-2840
rsrctypearticle
creationdate2012
addtitleCardiovascular Diabetology
searchscope
01000273
11006761
21006762
31007067
41007443
51007515
61007945
71008886
81009127
91009240
101009386
1110000002
1210000004
1310000005
1410000013
1510000015
1610000022
1710000038
1810000039
1910000041
2010000043
2110000047
2210000050
2310000053
2410000118
2510000119
2610000120
2710000155
2810000156
2910000157
3010000158
3110000198
3210000209
3310000217
3410000234
3510000238
3610000250
3710000253
3810000255
3910000256
4010000258
4110000260
4210000265
4310000270
4410000271
4510000281
4610000300
4710000302
4810000348
4910000349
5010000350
5110000353
5210000354
5310000356
5410000360
55proquest
scope
01000273
11006761
21006762
31007067
41007443
51007515
61007945
71008886
81009127
91009240
101009386
1110000002
1210000004
1310000005
1410000013
1510000015
1610000022
1710000038
1810000039
1910000041
2010000043
2110000047
2210000050
2310000053
2410000118
2510000119
2610000120
2710000155
2810000156
2910000157
3010000158
3110000198
3210000209
3310000217
3410000234
3510000238
3610000250
3710000253
3810000255
3910000256
4010000258
4110000260
4210000265
4310000270
4410000271
4510000281
4610000300
4710000302
4810000348
4910000349
5010000350
5110000353
5210000354
5310000356
5410000360
55proquest
lsr43
01000273true
11006761true
21006762true
31007067true
41007443false
51007515false
61007945true
71008886true
81009127true
91009240true
101009386true
1110000002false
1210000004false
1310000005false
1410000013false
1510000015false
1610000022false
1710000038false
1810000039true
1910000041false
2010000043false
2110000047true
2210000050false
2310000053false
2410000118true
2510000119true
2610000120false
2710000155true
2810000156true
2910000157true
3010000158true
3110000198false
3210000209false
3310000217false
3410000234false
3510000238false
3610000250false
3710000253false
3810000255true
3910000256true
4010000258true
4110000260false
4210000265false
4310000270true
4410000271true
4510000281true
4610000300true
4710000302true
4810000348true
4910000349false
5010000350false
5110000353false
5210000354false
5310000356false
5410000360true
startdate20120101
enddate20120101
citationpf 137 vol 11
lsr30VSR-Enriched:[pqid]
sort
titleAssociations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
authorOrtega-Azorín, Carolina ; Sorlí, Jose ; Asensio, Eva ; Coltell, Oscar ; Martínez-González, Miguel ; Salas-Salvadó, Jordi ; Covas, Maria-Isabel ; Arós, Fernando ; Lapetra, José ; Serra-Majem, Lluís ; Gómez-Gracia
creationdate20120101
lso0120120101
facets
frbrgroupid8151028803585275380
frbrtype5
languageeng
creationdate2012
topic
0Aged–Metabolism
1Aged, 80 & Over–Blood
2Blood Glucose–Diet Therapy
3Body Mass Index–Genetics
4Case-Control Studies–Physiopathology
5Chi-Square Distribution–Blood
6Diabetes Mellitus, Type 2–Genetics
7Diet, Mediterranean–Genetics
8Fasting–Genetics
9Female–Genetics
10Gene Frequency–Genetics
11Gene-Environment Interaction–Genetics
12Genetic Predisposition to Disease–Genetics
13Humans–Genetics
14Linear Models–Genetics
15Logistic Models
collection
0Medical Database
1Health & Medical Collection (Alumni edition)
2Medical Database (Alumni edition)
3Health & Medical Collection
4Publicly Available Content Database
5Engineering Research Database
6Technology Research Database
7ProQuest Biological Science Collection
8ProQuest Central
9ProQuest Engineering Collection
10ProQuest Environmental Science Collection
11ProQuest Hospital Collection
12ProQuest Natural Science Collection
13ProQuest Technology Collection
14Hospital Premium Collection (Alumni edition)
15ProQuest SciTech Collection
16ProQuest Health & Medical Complete
17ProQuest Medical Library
18Agricultural & Environmental Science Database
19Biological Science Database
20Materials Science & Engineering Database
21Natural Science Collection
22ProQuest Central (new)
23ProQuest Central Korea
24SciTech Premium Collection
25Technology Collection
26Health Research Premium Collection
27Health Research Premium Collection (Alumni edition)
28ProQuest Central Essentials
29ProQuest Central China
30ProQuest One Academic
31Environmental Science Index (ProQuest)
32Biological Science Index (ProQuest)
33Engineering Index (ProQuest)
34Environmental Science Collection (ProQuest)
35Engineering Collection (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Ortega-Azorín, Carolina
1Sorlí, Jose
2Asensio, Eva
3Coltell, Oscar
4Martínez-González, Miguel
5Salas-Salvadó, Jordi
6Covas, Maria-Isabel
7Arós, Fernando
8Lapetra, José
9Serra-Majem, Lluís
10Gómez-Gracia, Enrique
11Fiol, Miquel
12Sáez-Tormo, Guillermo
13Pintó, Xavier
14Muñoz, Miguel
15Ros, Emilio
16Ordovás, Jose
17Estruch, Ramon
18Corella, Dolores
jtitleCardiovascular Diabetology
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
aulast
0Ortega-Azorín
1Sorlí
2Asensio
3Coltell
4Martínez-González
5Salas-Salvadó
6Covas
7Arós
8Lapetra
9Serra-Majem
10Gómez-Gracia
11Fiol
12Sáez-Tormo
13Pintó
14Muñoz
15Ros
16Ordovás
17Estruch
18Corella
aufirst
0Carolina
1Jose
2Eva
3Oscar
4Miguel
5Jordi
6Maria-Isabel
7Fernando
8José
9Lluís
10Enrique
11Miquel
12Guillermo
13Xavier
14Emilio
15Ramon
16Dolores
auinit1
0C.
1J.
2E.
3O.
4M.
5F.
6L.
7G.
8X.
9R.
10D.
au
0Ortega-Azorín, Carolina
1Sorlí, Jose
2Asensio, Eva
3Coltell, Oscar
4Martínez-González, Miguel
5Salas-Salvadó, Jordi
6Covas, Maria-Isabel
7Arós, Fernando
8Lapetra, José
9Serra-Majem, Lluís
10Gómez-Gracia, Enrique
11Fiol, Miquel
12Sáez-Tormo, Guillermo
13Pintó, Xavier
14Muñoz, Miguel
15Ros, Emilio
16Ordovás, Jose
17Estruch, Ramon
18Corella, Dolores
atitleAssociations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
jtitleCardiovascular Diabetology
risdate20120101
volume11
spage137
pages137
eissn14752840
formatjournal
genrearticle
ristypeJOUR
abstractDoc number: 137 Abstract Background: Although the Fat Mass and Obesity (FTO ) and Melanocortin-4 Receptor (MC4R ) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). Methods: Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes cases and 3,622 non-diabetic subjects) with no differences in BMI. Diet was assessed by validated questionnaires. FTO -rs9939609 and MC4R -rs17782313 were determined. An aggregate genetic score was calculated to test additive effects. Gene-diet interactions were analyzed. Results:...
copLondon
pubBioMed Central
doi10.1186/1475-2840-11-137
urlhttp://search.proquest.com/docview/1151091819/
oafree_for_read
date2012-01-01