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Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for diabetes in youth study.

Persons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse... Full description

Journal Title: Journal of pediatric endocrinology & metabolism : JPEM 2012, Vol.25(7-8), pp.717-721
Main Author: Shah, Amy S
Other Authors: Dolan, Lawrence M , Lauer, Abigail , Davis, Cralen , Dabelea, Dana , Daniels, Stephen R , Hamman, Richard F , Marcovina, Santica , Wadwa, R Paul , Urbina, Elaine M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0334-018X
Link: http://search.proquest.com/docview/1178692830/?pq-origsite=primo
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recordid: proquest1178692830
title: Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for diabetes in youth study.
format: Article
creator:
  • Shah, Amy S
  • Dolan, Lawrence M
  • Lauer, Abigail
  • Davis, Cralen
  • Dabelea, Dana
  • Daniels, Stephen R
  • Hamman, Richard F
  • Marcovina, Santica
  • Wadwa, R Paul
  • Urbina, Elaine M
subjects:
  • Adiponectin–Analysis
  • Adolescent–Blood
  • Age Factors–Physiology
  • Blood Pressure–Blood
  • Child–Complications
  • Cohort Studies–Physiopathology
  • Diabetes Mellitus, Type 1–Physiology
  • Female–Physiology
  • Hemodynamics–Physiology
  • Humans–Physiology
  • Male–Physiology
  • Pulse Wave Analysis–Physiology
  • Regression Analysis–Physiology
  • Vascular Stiffness–Physiology
  • Adipoq Protein, Human
  • Adiponectin
ispartof: Journal of pediatric endocrinology & metabolism : JPEM, 2012, Vol.25(7-8), pp.717-721
description: Persons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse wave velocity (PWV), augmentation index (AIx-75), and brachial distensibility (BrachD) were collected in 225 adolescents. Outcomes were evaluated by sex, and regression models were used to determine whether adiponectin was an independent determinant of arterial stiffness. Males had lower adiponectin levels and stiffer vessels (lower BrachD, p < 0.01) than females. Unadjusted correlations revealed that adiponectin was correlated with BrachD (p < 0.01) but not PWV and AIx-75. After adjustment, adiponectin was not a significant predictor of BrachD. The most consistent predictors of increased stiffness were age, male sex, blood pressure, obesity, and total cholesterol (p < 0.05). Adiponectin's contributions...
language: eng
source:
identifier: ISSN: 0334-018X
fulltext: fulltext
issn:
  • 0334018X
  • 0334-018X
url: Link


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titleAdiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for diabetes in youth study.
creatorShah, Amy S ; Dolan, Lawrence M ; Lauer, Abigail ; Davis, Cralen ; Dabelea, Dana ; Daniels, Stephen R ; Hamman, Richard F ; Marcovina, Santica ; Wadwa, R Paul ; Urbina, Elaine M
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identifierISSN: 0334-018X
subjectAdiponectin–Analysis ; Adolescent–Blood ; Age Factors–Physiology ; Blood Pressure–Blood ; Child–Complications ; Cohort Studies–Physiopathology ; Diabetes Mellitus, Type 1–Physiology ; Female–Physiology ; Hemodynamics–Physiology ; Humans–Physiology ; Male–Physiology ; Pulse Wave Analysis–Physiology ; Regression Analysis–Physiology ; Vascular Stiffness–Physiology ; Adipoq Protein, Human ; Adiponectin
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descriptionPersons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse wave velocity (PWV), augmentation index (AIx-75), and brachial distensibility (BrachD) were collected in 225 adolescents. Outcomes were evaluated by sex, and regression models were used to determine whether adiponectin was an independent determinant of arterial stiffness. Males had lower adiponectin levels and stiffer vessels (lower BrachD, p < 0.01) than females. Unadjusted correlations revealed that adiponectin was correlated with BrachD (p < 0.01) but not PWV and AIx-75. After adjustment, adiponectin was not a significant predictor of BrachD. The most consistent predictors of increased stiffness were age, male sex, blood pressure, obesity, and total cholesterol (p < 0.05). Adiponectin's contributions...
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