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α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis.

BACKGROUNDPrior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results. OBJECTIVEWe conducted a meta-analysis to summarize the evidence regarding the relation of ALA and CVD risk. DESIGNWe searched multip... Full description

Journal Title: The American journal of clinical nutrition Vol.96(6), pp.1262-1273
Main Author: Pan, An
Other Authors: Chen, Mu , Chowdhury, Rajiv , Wu, Jason H Y , Sun, Qi , Campos, Hannia , Mozaffarian, Dariush , Hu, Frank B
Format: Electronic Article Electronic Article
Language: English
Subjects:
Created: December 2012
ID: E-ISSN: 1938-3207 ; DOI: 1938-3207 ; DOI: 10.3945/ajcn.112.044040
Link: http://search.proquest.com/docview/1186914823/?pq-origsite=primo
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title: α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis.
format: Article
creator:
  • Pan, An
  • Chen, Mu
  • Chowdhury, Rajiv
  • Wu, Jason H Y
  • Sun, Qi
  • Campos, Hannia
  • Mozaffarian, Dariush
  • Hu, Frank B
subjects:
  • Biomarkers–Blood
  • Cardiovascular Diseases–Blood
  • Diet–Epidemiology
  • Humans–Etiology
  • Reproducibility of Results–Prevention & Control
  • Risk–Adverse Effects
  • Alpha-Linolenic Acid–Administration & Dosage
  • Alpha-Linolenic Acid–Blood
  • Alpha-Linolenic Acid–Therapeutic Use
  • Abridged
  • Biomarkers
  • Alpha-Linolenic Acid
ispartof: The American journal of clinical nutrition, Vol.96(6), pp.1262-1273
description: BACKGROUNDPrior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results. OBJECTIVEWe conducted a meta-analysis to summarize the evidence regarding the relation of ALA and CVD risk. DESIGNWe searched multiple electronic databases through January 2012 for studies that reported the association between ALA (assessed as dietary intake or as a biomarker in blood or adipose tissue) and CVD risk in prospective and retrospective studies. We pooled the multivariate-adjusted RRs comparing the top with the bottom tertile of ALA using random-effects meta-analysis, which allowed for between-study heterogeneity. RESULTSTwenty-seven original studies were identified, including 251,049 individuals and 15,327 CVD events. The overall pooled RR was 0.86 (95% CI: 0.77, 0.97; I² = 71.3%). The association was significant in 13 comparisons that used dietary ALA as the exposure (pooled RR: 0.90; 95% CI: 0.81, 0.99; I² = 49.0%), with similar but nonsignificant trends in 17 comparisons in which ALA biomarkers were used as the exposure (pooled RR: 0.80; 95% CI: 0.63, 1.03; I² = 79.8%). An evaluation of mean participant age, study design (prospective compared with retrospective), exposure assessment (self-reported diet compared with biomarker), and outcome [fatal coronary heart disease (CHD), nonfatal CHD, total CHD, or stroke] showed that none were statistically significant sources of heterogeneity. CONCLUSIONSIn observational studies, higher ALA exposure is associated with a moderately lower risk of CVD. The results were generally consistent for dietary and biomarker studies but were not statistically significant for biomarker studies. However, the high unexplained heterogeneity highlights the need for additional well-designed observational studies and large randomized clinical trials to evaluate the effects of ALA on CVD.
language: eng
source:
identifier: E-ISSN: 1938-3207 ; DOI: 1938-3207 ; DOI: 10.3945/ajcn.112.044040
fulltext: fulltext
issn:
  • 19383207
  • 1938-3207
url: Link


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titleα-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis.
creatorPan, An ; Chen, Mu ; Chowdhury, Rajiv ; Wu, Jason H Y ; Sun, Qi ; Campos, Hannia ; Mozaffarian, Dariush ; Hu, Frank B
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subjectBiomarkers–Blood ; Cardiovascular Diseases–Blood ; Diet–Epidemiology ; Humans–Etiology ; Reproducibility of Results–Prevention & Control ; Risk–Adverse Effects ; Alpha-Linolenic Acid–Administration & Dosage ; Alpha-Linolenic Acid–Blood ; Alpha-Linolenic Acid–Therapeutic Use ; Abridged ; Biomarkers ; Alpha-Linolenic Acid
descriptionBACKGROUNDPrior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results. OBJECTIVEWe conducted a meta-analysis to summarize the evidence regarding the relation of ALA and CVD risk. DESIGNWe searched multiple electronic databases through January 2012 for studies that reported the association between ALA (assessed as dietary intake or as a biomarker in blood or adipose tissue) and CVD risk in prospective and retrospective studies. We pooled the multivariate-adjusted RRs comparing the top with the bottom tertile of ALA using random-effects meta-analysis, which allowed for between-study heterogeneity. RESULTSTwenty-seven original studies were identified, including 251,049 individuals and 15,327 CVD events. The overall pooled RR was 0.86 (95% CI: 0.77, 0.97; I² = 71.3%). The association was significant in 13 comparisons that used dietary ALA as the exposure (pooled RR: 0.90; 95% CI: 0.81, 0.99; I² = 49.0%), with similar but nonsignificant trends in 17 comparisons in which ALA biomarkers were used as the exposure (pooled RR: 0.80; 95% CI: 0.63, 1.03; I² = 79.8%). An evaluation of mean participant age, study design (prospective compared with retrospective), exposure assessment (self-reported diet compared with biomarker), and outcome [fatal coronary heart disease (CHD), nonfatal CHD, total CHD, or stroke] showed that none were statistically significant sources of heterogeneity. CONCLUSIONSIn observational studies, higher ALA exposure is associated with a moderately lower risk of CVD. The results were generally consistent for dietary and biomarker studies but were not statistically significant for biomarker studies. However, the high unexplained heterogeneity highlights the need for additional well-designed observational studies and large randomized clinical trials to evaluate the effects of ALA on CVD.
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titleα-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis.
descriptionBACKGROUNDPrior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results. OBJECTIVEWe conducted a meta-analysis to summarize the evidence regarding the relation of ALA and CVD risk. DESIGNWe searched multiple electronic databases through January 2012 for studies that reported the association between ALA (assessed as dietary intake or as a biomarker in blood or adipose tissue) and CVD risk in prospective and retrospective studies. We pooled the multivariate-adjusted RRs comparing the top with the bottom tertile of ALA using random-effects meta-analysis, which allowed for between-study heterogeneity. RESULTSTwenty-seven original studies were identified, including 251,049 individuals and 15,327 CVD events. The overall pooled RR was 0.86 (95% CI: 0.77, 0.97; I² = 71.3%). The association was significant in 13 comparisons that used dietary ALA as the exposure (pooled RR: 0.90; 95% CI: 0.81, 0.99; I² = 49.0%), with similar but nonsignificant trends in 17 comparisons in which ALA biomarkers were used as the exposure (pooled RR: 0.80; 95% CI: 0.63, 1.03; I² = 79.8%). An evaluation of mean participant age, study design (prospective compared with retrospective), exposure assessment (self-reported diet compared with biomarker), and outcome [fatal coronary heart disease (CHD), nonfatal CHD, total CHD, or stroke] showed that none were statistically significant sources of heterogeneity. CONCLUSIONSIn observational studies, higher ALA exposure is associated with a moderately lower risk of CVD. The results were generally consistent for dietary and biomarker studies but were not statistically significant for biomarker studies. However, the high unexplained heterogeneity highlights the need for additional well-designed observational studies and large randomized clinical trials to evaluate the effects of ALA on CVD.
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titleα-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis.
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abstractBACKGROUNDPrior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results. OBJECTIVEWe conducted a meta-analysis to summarize the evidence regarding the relation of ALA and CVD risk. DESIGNWe searched multiple electronic databases through January 2012 for studies that reported the association between ALA (assessed as dietary intake or as a biomarker in blood or adipose tissue) and CVD risk in prospective and retrospective studies. We pooled the multivariate-adjusted RRs comparing the top with the bottom tertile of ALA using random-effects meta-analysis, which allowed for between-study heterogeneity. RESULTSTwenty-seven original studies were identified, including 251,049 individuals and 15,327 CVD events. The overall pooled RR was 0.86 (95% CI: 0.77, 0.97; I² = 71.3%). The association was significant in 13 comparisons that used dietary ALA as the exposure (pooled RR: 0.90; 95% CI: 0.81, 0.99; I² = 49.0%), with similar but nonsignificant trends in 17 comparisons in which ALA biomarkers were used as the exposure (pooled RR: 0.80; 95% CI: 0.63, 1.03; I² = 79.8%). An evaluation of mean participant age, study design (prospective compared with retrospective), exposure assessment (self-reported diet compared with biomarker), and outcome [fatal coronary heart disease (CHD), nonfatal CHD, total CHD, or stroke] showed that none were statistically significant sources of heterogeneity. CONCLUSIONSIn observational studies, higher ALA exposure is associated with a moderately lower risk of CVD. The results were generally consistent for dietary and biomarker studies but were not statistically significant for biomarker studies. However, the high unexplained heterogeneity highlights the need for additional well-designed observational studies and large randomized clinical trials to evaluate the effects of ALA on CVD.
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