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Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis

Chronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown. We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis... Full description

Journal Title: The Lancet Nov 10, 2012, Vol.380(9854), pp.1662-73
Main Author: Fox, Caroline S
Other Authors: Matsushita, Kunihiro , Woodward, Mark , Bilo, Henk Jg , Chalmers, John , Heerspink, Hiddo J Lambers , Lee, Brian J , Perkins, Robert M , Rossing, Peter , Sairenchi, Toshimi , Tonelli, Marcello , Vassalotti, Joseph A , Yamagishi, Kazumasa , Coresh, Josef , de Jong, Paul E , Wen, Chi-Pang , Nelson, Robert G
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 01406736 ; E-ISSN: 1474547X ; DOI: 10.1016/S0140-6736(12)61350-6
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title: Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis
format: Article
creator:
  • Fox, Caroline S
  • Matsushita, Kunihiro
  • Woodward, Mark
  • Bilo, Henk Jg
  • Chalmers, John
  • Heerspink, Hiddo J Lambers
  • Lee, Brian J
  • Perkins, Robert M
  • Rossing, Peter
  • Sairenchi, Toshimi
  • Tonelli, Marcello
  • Vassalotti, Joseph A
  • Yamagishi, Kazumasa
  • Coresh, Josef
  • de Jong, Paul E
  • Wen, Chi-Pang
  • Nelson, Robert G
subjects:
  • Aged–Mortality
  • Albuminuria–Physiopathology
  • Albuminuria–Mortality
  • Cardiovascular Diseases–Mortality
  • Cause of Death–Physiopathology
  • Diabetic Nephropathies–Urine
  • Diabetic Nephropathies–Physiology
  • Diabetic Nephropathies–Mortality
  • Female–Physiopathology
  • Glomerular Filtration Rate–Urine
  • Humans–Urine
  • Kidney Failure, Chronic–Urine
  • Kidney Failure, Chronic–Urine
  • Kidney Failure, Chronic–Urine
  • Male–Urine
  • Middle Aged–Urine
  • Risk Factors–Urine
  • Kidney Diseases
  • Mortality
  • Studies
ispartof: The Lancet, Nov 10, 2012, Vol.380(9854), pp.1662-73
description: Chronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown. We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes. We analysed data for 1 024 977 participants (128 505 with diabetes) from 30 general population and high-risk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and high-risk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8·5 years (SD 5·0). In the 23 studies with data for cardiovascular mortality, 21 237 deaths...
language: eng
source:
identifier: ISSN: 01406736 ; E-ISSN: 1474547X ; DOI: 10.1016/S0140-6736(12)61350-6
fulltext: fulltext
issn:
  • 01406736
  • 0140-6736
  • 1474547X
  • 1474-547X
url: Link


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titleAssociations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis
creatorFox, Caroline S ; Matsushita, Kunihiro ; Woodward, Mark ; Bilo, Henk Jg ; Chalmers, John ; Heerspink, Hiddo J Lambers ; Lee, Brian J ; Perkins, Robert M ; Rossing, Peter ; Sairenchi, Toshimi ; Tonelli, Marcello ; Vassalotti, Joseph A ; Yamagishi, Kazumasa ; Coresh, Josef ; de Jong, Paul E ; Wen, Chi-Pang ; Nelson, Robert G
contributorNelson, Robert G (corporate/institutional author) ; Nelson, Robert G (corporate/institutional author)
ispartofThe Lancet, Nov 10, 2012, Vol.380(9854), pp.1662-73
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subjectAged–Mortality ; Albuminuria–Physiopathology ; Albuminuria–Mortality ; Cardiovascular Diseases–Mortality ; Cause of Death–Physiopathology ; Diabetic Nephropathies–Urine ; Diabetic Nephropathies–Physiology ; Diabetic Nephropathies–Mortality ; Female–Physiopathology ; Glomerular Filtration Rate–Urine ; Humans–Urine ; Kidney Failure, Chronic–Urine ; Kidney Failure, Chronic–Urine ; Kidney Failure, Chronic–Urine ; Male–Urine ; Middle Aged–Urine ; Risk Factors–Urine ; Kidney Diseases ; Mortality ; Studies
descriptionChronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown. We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes. We analysed data for 1 024 977 participants (128 505 with diabetes) from 30 general population and high-risk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and high-risk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8·5 years (SD 5·0). In the 23 studies with data for cardiovascular mortality, 21 237 deaths...
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titleAssociations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis
descriptionChronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown. We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes. We analysed data for 1 024 977 participants (128 505 with diabetes) from 30 general population and high-risk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and high-risk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8·5 years (SD 5·0). In the 23 studies with data for cardiovascular mortality, 21 237 deaths...
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citationpf 1662 pt 73 vol 380 issue 9854
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titleAssociations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis
authorFox, Caroline S ; Matsushita, Kunihiro ; Woodward, Mark ; Bilo, Henk Jg ; Chalmers, John ; Heerspink, Hiddo J Lambers ; Lee, Brian J ; Perkins, Robert M ; Rossing, Peter ; Sairenchi, Toshimi ; Tonelli, Marcello ; Vassalotti, Joseph A ; Yamagishi, Kazumasa ; Coresh, Josef ; de Jong, Paul E ; Wen, Chi-Pang ; Nelson, Robert G
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1Albuminuria–Physiopathology
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3Cardiovascular Diseases–Mortality
4Cause of Death–Physiopathology
5Diabetic Nephropathies–Urine
6Diabetic Nephropathies–Physiology
7Diabetic Nephropathies–Mortality
8Female–Physiopathology
9Glomerular Filtration Rate–Urine
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16Mortality
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8Psychology Database (Alumni edition)
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abstractChronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown. We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes. We analysed data for 1 024 977 participants (128 505 with diabetes) from 30 general population and high-risk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and high-risk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8·5 years (SD 5·0). In the 23 studies with data for cardiovascular mortality, 21 237 deaths...
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doi10.1016/S0140-6736(12)61350-6
urlhttp://search.proquest.com/docview/1197636701/
date2012-11-10