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Arterial thromboembolism in cancer patients treated with cisplatin: a systematic review and meta-analysis.

Cisplatin has been associated with an increased risk of arterial thromboembolic events (ATEs). However, because this association is mostly based on case reports and retrospective studies, we conducted a systemic review and meta-analysis of randomized controlled trials evaluating the incidence and ri... Full description

Journal Title: Journal of the National Cancer Institute December 5, 2012, Vol.104(23), pp.1837-1840
Main Author: Proverbs-Singh, Tracy
Other Authors: Chiu, Sophia K , Liu, Ziyue , Seng, Sonia , Sonpavde, Guru , Choueiri, Toni K , Tsao, Che-Kai , Yu, Menggang , Hahn, Noah M , Oh, William K , Galsky, Matthew D
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1460-2105 ; DOI: 10.1093/jnci/djs435
Link: http://search.proquest.com/docview/1223430196/?pq-origsite=primo
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title: Arterial thromboembolism in cancer patients treated with cisplatin: a systematic review and meta-analysis.
format: Article
creator:
  • Proverbs-Singh, Tracy
  • Chiu, Sophia K
  • Liu, Ziyue
  • Seng, Sonia
  • Sonpavde, Guru
  • Choueiri, Toni K
  • Tsao, Che-Kai
  • Yu, Menggang
  • Hahn, Noah M
  • Oh, William K
  • Galsky, Matthew D
subjects:
  • Antineoplastic Agents–Administration & Dosage
  • Antineoplastic Combined Chemotherapy Protocols–Adverse Effects
  • Arteries–Adverse Effects
  • Cisplatin–Administration & Dosage
  • Clinical Trials, Phase II As Topic–Adverse Effects
  • Clinical Trials, Phase III As Topic–Drug Therapy
  • Humans–Chemically Induced
  • Incidence–Epidemiology
  • Neoplasms–Epidemiology
  • Randomized Controlled Trials As Topic–Epidemiology
  • Risk–Epidemiology
  • Thromboembolism–Epidemiology
  • Antineoplastic Agents
  • Cisplatin
ispartof: Journal of the National Cancer Institute, December 5, 2012, Vol.104(23), pp.1837-1840
description: Cisplatin has been associated with an increased risk of arterial thromboembolic events (ATEs). However, because this association is mostly based on case reports and retrospective studies, we conducted a systemic review and meta-analysis of randomized controlled trials evaluating the incidence and risk of ATEs associated with cisplatin. Eligible studies included prospective randomized phase II and III trials evaluating cisplatin-based vs non-cisplatin-based chemotherapy in patients with solid tumors, which were identified from PubMed articles published between 1990 and 2010. Incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated using a random effects model. A total of 8216 patients from 38 trials were included. Among patients treated with cisplatin-based chemotherapy, the summary incidence of ATEs was 0.67% (95% CI = 0.40% to 0.95%), and the RR of ATEs was 1.36 (95% CI = 0.86 to 2.17; P= .19). No increase in ATEs was detected in any prespecified subgroup. J Natl Cancer Inst 2012:104;1837-1840 DOI: 10.1093/jnci/djs435
language: eng
source:
identifier: E-ISSN: 1460-2105 ; DOI: 10.1093/jnci/djs435
fulltext: fulltext
issn:
  • 14602105
  • 1460-2105
url: Link


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titleArterial thromboembolism in cancer patients treated with cisplatin: a systematic review and meta-analysis.
creatorProverbs-Singh, Tracy ; Chiu, Sophia K ; Liu, Ziyue ; Seng, Sonia ; Sonpavde, Guru ; Choueiri, Toni K ; Tsao, Che-Kai ; Yu, Menggang ; Hahn, Noah M ; Oh, William K ; Galsky, Matthew D
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ispartofJournal of the National Cancer Institute, December 5, 2012, Vol.104(23), pp.1837-1840
identifierE-ISSN: 1460-2105 ; DOI: 10.1093/jnci/djs435
subjectAntineoplastic Agents–Administration & Dosage ; Antineoplastic Combined Chemotherapy Protocols–Adverse Effects ; Arteries–Adverse Effects ; Cisplatin–Administration & Dosage ; Clinical Trials, Phase II As Topic–Adverse Effects ; Clinical Trials, Phase III As Topic–Drug Therapy ; Humans–Chemically Induced ; Incidence–Epidemiology ; Neoplasms–Epidemiology ; Randomized Controlled Trials As Topic–Epidemiology ; Risk–Epidemiology ; Thromboembolism–Epidemiology ; Antineoplastic Agents ; Cisplatin
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descriptionCisplatin has been associated with an increased risk of arterial thromboembolic events (ATEs). However, because this association is mostly based on case reports and retrospective studies, we conducted a systemic review and meta-analysis of randomized controlled trials evaluating the incidence and risk of ATEs associated with cisplatin. Eligible studies included prospective randomized phase II and III trials evaluating cisplatin-based vs non-cisplatin-based chemotherapy in patients with solid tumors, which were identified from PubMed articles published between 1990 and 2010. Incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated using a random effects model. A total of 8216 patients from 38 trials were included. Among patients treated with cisplatin-based chemotherapy, the summary incidence of ATEs was 0.67% (95% CI = 0.40% to 0.95%), and the RR of ATEs was 1.36 (95% CI = 0.86 to 2.17; P= .19). No increase in ATEs was detected in any prespecified subgroup. J Natl Cancer Inst 2012:104;1837-1840 DOI: 10.1093/jnci/djs435
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authorProverbs-Singh, Tracy ; Chiu, Sophia K ; Liu, Ziyue ; Seng, Sonia ; Sonpavde, Guru ; Choueiri, Toni K ; Tsao, Che-Kai ; Yu, Menggang ; Hahn, Noah M ; Oh, William K ; Galsky, Matthew D
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