schliessen

Filtern

 

Bibliotheken

Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA

To apply dynamic contrast-enhanced (DCE) MRI on patients presenting with elevated liver enzymes without clinical signs of hepatic decompensation in order to quantitatively compare the hepatocyte-specific uptake of Gd-EOB-DTPA with histopathological fibrosis stage. A total of 38 patients were prospec... Full description

Journal Title: European Radiology Jan 2013, Vol.23(1), pp.174-81
Main Author: Norén, Bengt
Other Authors: Forsgren, Mikael , Dahlqvist Leinhard, Olof , Dahlström, Nils , Kihlberg, Johan , Romu, Thobias , Kechagias, Stergios , Almer, Sven , Smedby, Örjan , Lundberg, Peter
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 09387994 ; E-ISSN: 14321084 ; DOI: 10.1007/s00330-012-2583-2
Link: http://search.proquest.com/docview/1266500440/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1266500440
title: Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA
format: Article
creator:
  • Norén, Bengt
  • Forsgren, Mikael
  • Dahlqvist Leinhard, Olof
  • Dahlström, Nils
  • Kihlberg, Johan
  • Romu, Thobias
  • Kechagias, Stergios
  • Almer, Sven
  • Smedby, Örjan
  • Lundberg, Peter
subjects:
  • Adult–Pharmacokinetics
  • Aged–Pharmacokinetics
  • Area Under Curve–Methods
  • Biopsy–Methods
  • Contrast Media–Pathology
  • Female–Pathology
  • Gadolinium Dtpa–Pathology
  • Humans–Pathology
  • Image Enhancement–Pathology
  • Image Interpretation, Computer-Assisted–Pathology
  • Liver Cirrhosis–Pathology
  • Male–Pathology
  • Middle Aged–Pathology
  • Prospective Studies–Pathology
  • ROC Curve–Pathology
  • Software–Pathology
  • Ultrasonography, Interventional–Pathology
  • Contrast Media
  • Gadolinium Ethoxybenzyl Dtpa
  • Gadolinium Dtpa
ispartof: European Radiology, Jan 2013, Vol.23(1), pp.174-81
description: To apply dynamic contrast-enhanced (DCE) MRI on patients presenting with elevated liver enzymes without clinical signs of hepatic decompensation in order to quantitatively compare the hepatocyte-specific uptake of Gd-EOB-DTPA with histopathological fibrosis stage. A total of 38 patients were prospectively examined using 1.5-T MRI. Data were acquired from regions of interest in the liver and spleen by using time series of single-breath-hold symmetrically sampled two-point Dixon 3D images (non-enhanced, arterial and venous portal phase; 3, 10, 20 and 30 min) following a bolus injection of Gd-EOB-DTPA (0.025 mmol/kg). The signal intensity (SI) values were reconstructed using a phase-sensitive technique and normalised using multiscale adaptive normalising averaging (MANA). Liver-to-spleen contrast ratios (LSC_N) and the contrast uptake rate (K ^sub Hep^) were calculated. Liver biopsy was performed and classified according to the Batts and Ludwig system. Area under the receiver-operating characteristic...
language: eng
source:
identifier: ISSN: 09387994 ; E-ISSN: 14321084 ; DOI: 10.1007/s00330-012-2583-2
fulltext: fulltext
issn:
  • 09387994
  • 0938-7994
  • 14321084
  • 1432-1084
url: Link


@attributes
ID166641436
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1266500440
sourceidproquest
recordidTN_proquest1266500440
sourcesystemPC
pqid1266500440
galeid314436505
display
typearticle
titleSeparation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA
creatorNorén, Bengt ; Forsgren, Mikael ; Dahlqvist Leinhard, Olof ; Dahlström, Nils ; Kihlberg, Johan ; Romu, Thobias ; Kechagias, Stergios ; Almer, Sven ; Smedby, Örjan ; Lundberg, Peter
ispartofEuropean Radiology, Jan 2013, Vol.23(1), pp.174-81
identifier
subjectAdult–Pharmacokinetics ; Aged–Pharmacokinetics ; Area Under Curve–Methods ; Biopsy–Methods ; Contrast Media–Pathology ; Female–Pathology ; Gadolinium Dtpa–Pathology ; Humans–Pathology ; Image Enhancement–Pathology ; Image Interpretation, Computer-Assisted–Pathology ; Liver Cirrhosis–Pathology ; Male–Pathology ; Middle Aged–Pathology ; Prospective Studies–Pathology ; ROC Curve–Pathology ; Software–Pathology ; Ultrasonography, Interventional–Pathology ; Contrast Media ; Gadolinium Ethoxybenzyl Dtpa ; Gadolinium Dtpa
descriptionTo apply dynamic contrast-enhanced (DCE) MRI on patients presenting with elevated liver enzymes without clinical signs of hepatic decompensation in order to quantitatively compare the hepatocyte-specific uptake of Gd-EOB-DTPA with histopathological fibrosis stage. A total of 38 patients were prospectively examined using 1.5-T MRI. Data were acquired from regions of interest in the liver and spleen by using time series of single-breath-hold symmetrically sampled two-point Dixon 3D images (non-enhanced, arterial and venous portal phase; 3, 10, 20 and 30 min) following a bolus injection of Gd-EOB-DTPA (0.025 mmol/kg). The signal intensity (SI) values were reconstructed using a phase-sensitive technique and normalised using multiscale adaptive normalising averaging (MANA). Liver-to-spleen contrast ratios (LSC_N) and the contrast uptake rate (K ^sub Hep^) were calculated. Liver biopsy was performed and classified according to the Batts and Ludwig system. Area under the receiver-operating characteristic...
languageeng
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1266500440/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Norén, Bengt
1Forsgren, Mikael
2Dahlqvist Leinhard, Olof
3Dahlström, Nils
4Kihlberg, Johan
5Romu, Thobias
6Kechagias, Stergios
7Almer, Sven
8Smedby, Örjan
9Lundberg, Peter
titleSeparation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA
descriptionTo apply dynamic contrast-enhanced (DCE) MRI on patients presenting with elevated liver enzymes without clinical signs of hepatic decompensation in order to quantitatively compare the hepatocyte-specific uptake of Gd-EOB-DTPA with histopathological fibrosis stage. A total of 38 patients were prospectively examined using 1.5-T MRI. Data were acquired from regions of interest in the liver and spleen by using time series of single-breath-hold symmetrically sampled two-point Dixon 3D images (non-enhanced, arterial and venous portal phase; 3, 10, 20 and 30 min) following a bolus injection of Gd-EOB-DTPA (0.025 mmol/kg). The signal intensity (SI) values were reconstructed using a phase-sensitive technique and normalised using multiscale adaptive normalising averaging (MANA). Liver-to-spleen contrast ratios (LSC_N) and the contrast uptake rate (K ^sub Hep^) were calculated. Liver biopsy was performed and classified according to the Batts and Ludwig system. Area under the receiver-operating characteristic...
subject
0Adult–Pharmacokinetics
1Aged–Pharmacokinetics
2Area Under Curve–Methods
3Biopsy–Methods
4Contrast Media–Pathology
5Female–Pathology
6Gadolinium Dtpa–Pathology
7Humans–Pathology
8Image Enhancement–Pathology
9Image Interpretation, Computer-Assisted–Pathology
10Liver Cirrhosis–Pathology
11Male–Pathology
12Middle Aged–Pathology
13Prospective Studies–Pathology
14ROC Curve–Pathology
15Software–Pathology
16Ultrasonography, Interventional–Pathology
17Contrast Media
18Gadolinium Ethoxybenzyl Dtpa
19Gadolinium Dtpa
general
0English
1Springer Nature B.V.
210.1007/s00330-012-2583-2
3Medical Database
4Health & Medical Collection (Alumni edition)
5Medical Database (Alumni edition)
6Nursing & Allied Health Database (Alumni edition)
7ProQuest Pharma Collection
8Health & Medical Collection
9Nursing & Allied Health Database
10Advanced Technologies & Aerospace Database
11Biological Science Database
12Engineering Research Database
13Technology Research Database
14ProQuest Nursing & Allied Health Source
15ProQuest Biological Science Collection
16ProQuest Central
17ProQuest Engineering Collection
18ProQuest Environmental Science Collection
19ProQuest Advanced Technologies & Aerospace Collection
20ProQuest Hospital Collection
21ProQuest Natural Science Collection
22ProQuest Technology Collection
23Hospital Premium Collection (Alumni edition)
24ProQuest SciTech Collection
25ProQuest Health & Medical Complete
26ProQuest Medical Library
27Agricultural & Environmental Science Database
28Materials Science & Engineering Database
29Natural Science Collection
30ProQuest Central (new)
31ProQuest Central K-12
32ProQuest Central Korea
33SciTech Premium Collection
34Technology Collection
35Health Research Premium Collection
36Health Research Premium Collection (Alumni edition)
37ProQuest Central Essentials
38ProQuest Central China
39ProQuest One Academic
40Environmental Science Index (ProQuest)
41Biological Science Index (ProQuest)
42Engineering Index (ProQuest)
43Environmental Science Collection (ProQuest)
44Engineering Collection (ProQuest)
sourceidproquest
recordidproquest1266500440
issn
009387994
10938-7994
214321084
31432-1084
rsrctypearticle
creationdate2013
addtitleEuropean Radiology
searchscope
01000273
11006761
21006762
31006763
41006815
51007067
61007107
71007443
81007852
91007856
101007945
111008886
121009127
131009386
1410000004
1510000005
1610000013
1710000015
1810000020
1910000022
2010000038
2110000039
2210000041
2310000043
2410000045
2510000047
2610000050
2710000053
2810000117
2910000118
3010000119
3110000120
3210000155
3310000156
3410000157
3510000158
3610000198
3710000209
3810000217
3910000233
4010000234
4110000238
4210000250
4310000253
4410000255
4510000256
4610000257
4710000258
4810000260
4910000265
5010000268
5110000270
5210000271
5310000281
5410000300
5510000302
5610000348
5710000349
5810000350
5910000353
6010000354
6110000356
6210000360
63proquest
scope
01000273
11006761
21006762
31006763
41006815
51007067
61007107
71007443
81007852
91007856
101007945
111008886
121009127
131009386
1410000004
1510000005
1610000013
1710000015
1810000020
1910000022
2010000038
2110000039
2210000041
2310000043
2410000045
2510000047
2610000050
2710000053
2810000117
2910000118
3010000119
3110000120
3210000155
3310000156
3410000157
3510000158
3610000198
3710000209
3810000217
3910000233
4010000234
4110000238
4210000250
4310000253
4410000255
4510000256
4610000257
4710000258
4810000260
4910000265
5010000268
5110000270
5210000271
5310000281
5410000300
5510000302
5610000348
5710000349
5810000350
5910000353
6010000354
6110000356
6210000360
63proquest
lsr43
01000273true
11006761true
21006762true
31006763true
41006815true
51007067true
61007107true
71007443false
81007852true
91007856true
101007945true
111008886true
121009127true
131009386true
1410000004false
1510000005false
1610000013false
1710000015false
1810000020true
1910000022false
2010000038true
2110000039true
2210000041false
2310000043false
2410000045true
2510000047true
2610000050true
2710000053true
2810000117true
2910000118true
3010000119true
3110000120true
3210000155true
3310000156true
3410000157true
3510000158true
3610000198false
3710000209false
3810000217false
3910000233true
4010000234false
4110000238true
4210000250false
4310000253true
4410000255true
4510000256true
4610000257true
4710000258true
4810000260true
4910000265true
5010000268true
5110000270true
5210000271true
5310000281true
5410000300true
5510000302true
5610000348true
5710000349false
5810000350false
5910000353false
6010000354false
6110000356false
6210000360true
startdate20130101
enddate20130101
citationpf 174 pt 81 vol 23 issue 1
lsr30VSR-Enriched:[pqid, galeid, pages]
sort
titleSeparation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA
authorNorén, Bengt ; Forsgren, Mikael ; Dahlqvist Leinhard, Olof ; Dahlström, Nils ; Kihlberg, Johan ; Romu, Thobias ; Kechagias, Stergios ; Almer, Sven ; Smedby, Örjan ; Lundberg, Peter
creationdate20130101
lso0120130101
facets
frbrgroupid6831124113207519133
frbrtype5
languageeng
creationdate2013
topic
0Adult–Pharmacokinetics
1Aged–Pharmacokinetics
2Area Under Curve–Methods
3Biopsy–Methods
4Contrast Media–Pathology
5Female–Pathology
6Gadolinium Dtpa–Pathology
7Humans–Pathology
8Image Enhancement–Pathology
9Image Interpretation, Computer-Assisted–Pathology
10Liver Cirrhosis–Pathology
11Male–Pathology
12Middle Aged–Pathology
13Prospective Studies–Pathology
14ROC Curve–Pathology
15Software–Pathology
16Ultrasonography, Interventional–Pathology
17Contrast Media
18Gadolinium Ethoxybenzyl Dtpa
19Gadolinium Dtpa
collection
0Medical Database
1Health & Medical Collection (Alumni edition)
2Medical Database (Alumni edition)
3Nursing & Allied Health Database (Alumni edition)
4ProQuest Pharma Collection
5Health & Medical Collection
6Nursing & Allied Health Database
7Advanced Technologies & Aerospace Database
8Biological Science Database
9Engineering Research Database
10Technology Research Database
11ProQuest Nursing & Allied Health Source
12ProQuest Biological Science Collection
13ProQuest Central
14ProQuest Engineering Collection
15ProQuest Environmental Science Collection
16ProQuest Advanced Technologies & Aerospace Collection
17ProQuest Hospital Collection
18ProQuest Natural Science Collection
19ProQuest Technology Collection
20Hospital Premium Collection (Alumni edition)
21ProQuest SciTech Collection
22ProQuest Health & Medical Complete
23ProQuest Medical Library
24Agricultural & Environmental Science Database
25Materials Science & Engineering Database
26Natural Science Collection
27ProQuest Central (new)
28ProQuest Central K-12
29ProQuest Central Korea
30SciTech Premium Collection
31Technology Collection
32Health Research Premium Collection
33Health Research Premium Collection (Alumni edition)
34ProQuest Central Essentials
35ProQuest Central China
36ProQuest One Academic
37Environmental Science Index (ProQuest)
38Biological Science Index (ProQuest)
39Engineering Index (ProQuest)
40Environmental Science Collection (ProQuest)
41Engineering Collection (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Norén, Bengt
1Forsgren, Mikael
2Dahlqvist Leinhard, Olof
3Dahlström, Nils
4Kihlberg, Johan
5Romu, Thobias
6Kechagias, Stergios
7Almer, Sven
8Smedby, Örjan
9Lundberg, Peter
jtitleEuropean Radiology
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Norén
1Forsgren
2Dahlqvist Leinhard
3Dahlström
4Kihlberg
5Romu
6Kechagias
7Almer
8Smedby
9Lundberg
aufirst
0Bengt
1Mikael
2Olof
3Nils
4Johan
5Thobias
6Stergios
7Sven
8Örjan
9Peter
auinit1
0B.
1M.
2O.
3N.
4J.
5T.
6S.
7R.
8P.
au
0Norén, Bengt
1Forsgren, Mikael
2Dahlqvist Leinhard, Olof
3Dahlström, Nils
4Kihlberg, Johan
5Romu, Thobias
6Kechagias, Stergios
7Almer, Sven
8Smedby, Örjan
9Lundberg, Peter
atitleSeparation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA
jtitleEuropean Radiology
risdate20130101
volume23
issue1
spage174
epage81
pages174-181
issn09387994
eissn14321084
formatjournal
genrearticle
ristypeJOUR
abstractTo apply dynamic contrast-enhanced (DCE) MRI on patients presenting with elevated liver enzymes without clinical signs of hepatic decompensation in order to quantitatively compare the hepatocyte-specific uptake of Gd-EOB-DTPA with histopathological fibrosis stage. A total of 38 patients were prospectively examined using 1.5-T MRI. Data were acquired from regions of interest in the liver and spleen by using time series of single-breath-hold symmetrically sampled two-point Dixon 3D images (non-enhanced, arterial and venous portal phase; 3, 10, 20 and 30 min) following a bolus injection of Gd-EOB-DTPA (0.025 mmol/kg). The signal intensity (SI) values were reconstructed using a phase-sensitive technique and normalised using multiscale adaptive normalising averaging (MANA). Liver-to-spleen contrast ratios (LSC_N) and the contrast uptake rate (K ^sub Hep^) were calculated. Liver biopsy was performed and classified according to the Batts and Ludwig system. Area under the receiver-operating characteristic...
copHeidelberg
pubSpringer Nature B.V.
doi10.1007/s00330-012-2583-2
urlhttp://search.proquest.com/docview/1266500440/
date2013-01-01