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Liposome-encapsulated peptides protect against experimental allergic encephalitis.

Multiple sclerosis (MS) is a severe inflammatory and neurodegenerative disease with an autoimmune background. Despite the variety of therapeutics available against MS, the development of novel approaches to its treatment is of high importance in modern pharmaceutics. In this study, experimental auto... Full description

Journal Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology January 2013, Vol.27(1), pp.222-231
Main Author: Belogurov, Alexey A
Other Authors: Stepanov, Alexey V , Smirnov, Ivan V , Melamed, Dobroslav , Bacon, Andrew , Mamedov, Azad E , Boitsov, Vitali M , Sashchenko, Lidia P , Ponomarenko, Natalia A , Sharanova, Svetlana N , Boyko, Alexey N , Dubina, Michael V , Friboulet, Alain , Genkin, Dmitry D , Gabibov, Alexander G
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1530-6860 ; DOI: 1530-6860 ; DOI: 10.1096/fj.12-213975
Link: http://search.proquest.com/docview/1273167437/?pq-origsite=primo
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title: Liposome-encapsulated peptides protect against experimental allergic encephalitis.
format: Article
creator:
  • Belogurov, Alexey A
  • Stepanov, Alexey V
  • Smirnov, Ivan V
  • Melamed, Dobroslav
  • Bacon, Andrew
  • Mamedov, Azad E
  • Boitsov, Vitali M
  • Sashchenko, Lidia P
  • Ponomarenko, Natalia A
  • Sharanova, Svetlana N
  • Boyko, Alexey N
  • Dubina, Michael V
  • Friboulet, Alain
  • Genkin, Dmitry D
  • Gabibov, Alexander G
subjects:
  • Animals–Etiology
  • Blotting, Western–Prevention & Control
  • Encephalitis–Complications
  • Enzyme-Linked Immunosorbent Assay–Prevention & Control
  • Female–Therapeutic Use
  • Humans–Therapeutic Use
  • Hypersensitivity–Therapeutic Use
  • Liposomes–Therapeutic Use
  • Mice–Therapeutic Use
  • Peptides–Therapeutic Use
  • Rats–Therapeutic Use
  • Surface Plasmon Resonance–Therapeutic Use
  • Liposomes
  • Peptides
ispartof: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, January 2013, Vol.27(1), pp.222-231
description: Multiple sclerosis (MS) is a severe inflammatory and neurodegenerative disease with an autoimmune background. Despite the variety of therapeutics available against MS, the development of novel approaches to its treatment is of high importance in modern pharmaceutics. In this study, experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats has been treated with immunodominant peptides of the myelin basic protein (MBP) encapsulated in mannosylated small unilamellar vesicles. The results show that liposome-encapsulated MBP 46–62 is the most effective in reducing maximal disease score during the first attack, while MBP 124–139 and MBP 147–170 can completely prevent the development of the exacerbation stage. Both mannosylation of liposomes and encapsulation of peptides are critical for the therapeutic effect, since neither naked peptides nor nonmannosylated liposomes, loaded or empty, have proved effective. The liposome-mediated synergistic effect of the mixture of 3 MBP peptides significantly suppresses the progression of protracted EAE, with the median cumulative disease score being reduced from 22 to 14 points, compared to the placebo group; prevents the production of circulating autoantibodies; down-regulates the synthesis of Th1 cytokines; and induces the production of brain-derived neurotrophic factor in the central nervous system. Thus, the proposed formulation ameliorates EAE, providing for a less severe first attack and rapid recovery from exacerbation, and offers a promising therapeutic modality in MS treatment.—Belogurov, A. A., Jr., Stepanov, A. V., Smirnov, I. V., Melamed, D., Bacon, A., Mamedov, A. E., Boitsov, V. M., Sashchenko, L. P., Ponomarenko, N. A., Sharanova, S. N., Boyko, A. N., Dubina, M. V., Friboulet, A., Genkin, D. D., Gabibov, A. G. Liposome-encapsulated peptides protect against experimental allergic encephalitis.
language: eng
source:
identifier: E-ISSN: 1530-6860 ; DOI: 1530-6860 ; DOI: 10.1096/fj.12-213975
fulltext: fulltext
issn:
  • 15306860
  • 1530-6860
url: Link


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titleLiposome-encapsulated peptides protect against experimental allergic encephalitis.
creatorBelogurov, Alexey A ; Stepanov, Alexey V ; Smirnov, Ivan V ; Melamed, Dobroslav ; Bacon, Andrew ; Mamedov, Azad E ; Boitsov, Vitali M ; Sashchenko, Lidia P ; Ponomarenko, Natalia A ; Sharanova, Svetlana N ; Boyko, Alexey N ; Dubina, Michael V ; Friboulet, Alain ; Genkin, Dmitry D ; Gabibov, Alexander G
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subjectAnimals–Etiology ; Blotting, Western–Prevention & Control ; Encephalitis–Complications ; Enzyme-Linked Immunosorbent Assay–Prevention & Control ; Female–Therapeutic Use ; Humans–Therapeutic Use ; Hypersensitivity–Therapeutic Use ; Liposomes–Therapeutic Use ; Mice–Therapeutic Use ; Peptides–Therapeutic Use ; Rats–Therapeutic Use ; Surface Plasmon Resonance–Therapeutic Use ; Liposomes ; Peptides
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descriptionMultiple sclerosis (MS) is a severe inflammatory and neurodegenerative disease with an autoimmune background. Despite the variety of therapeutics available against MS, the development of novel approaches to its treatment is of high importance in modern pharmaceutics. In this study, experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats has been treated with immunodominant peptides of the myelin basic protein (MBP) encapsulated in mannosylated small unilamellar vesicles. The results show that liposome-encapsulated MBP 46–62 is the most effective in reducing maximal disease score during the first attack, while MBP 124–139 and MBP 147–170 can completely prevent the development of the exacerbation stage. Both mannosylation of liposomes and encapsulation of peptides are critical for the therapeutic effect, since neither naked peptides nor nonmannosylated liposomes, loaded or empty, have proved effective. The liposome-mediated synergistic effect of the mixture of 3 MBP peptides significantly suppresses the progression of protracted EAE, with the median cumulative disease score being reduced from 22 to 14 points, compared to the placebo group; prevents the production of circulating autoantibodies; down-regulates the synthesis of Th1 cytokines; and induces the production of brain-derived neurotrophic factor in the central nervous system. Thus, the proposed formulation ameliorates EAE, providing for a less severe first attack and rapid recovery from exacerbation, and offers a promising therapeutic modality in MS treatment.—Belogurov, A. A., Jr., Stepanov, A. V., Smirnov, I. V., Melamed, D., Bacon, A., Mamedov, A. E., Boitsov, V. M., Sashchenko, L. P., Ponomarenko, N. A., Sharanova, S. N., Boyko, A. N., Dubina, M. V., Friboulet, A., Genkin, D. D., Gabibov, A. G. Liposome-encapsulated peptides protect against experimental allergic encephalitis.
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authorBelogurov, Alexey A ; Stepanov, Alexey V ; Smirnov, Ivan V ; Melamed, Dobroslav ; Bacon, Andrew ; Mamedov, Azad E ; Boitsov, Vitali M ; Sashchenko, Lidia P ; Ponomarenko, Natalia A ; Sharanova, Svetlana N ; Boyko, Alexey N ; Dubina, Michael V ; Friboulet, Alain ; Genkin, Dmitry D ; Gabibov, Alexander G
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