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Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease.

Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O(2) in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe-O(2) intermediate, using resonance Raman spectroscopy, involved in reactive oxygen s... Full description

Journal Title: Chemical communications (Cambridge England), February 4, 2013, Vol.49(11), pp.1091-1093
Main Author: Seal, Manas
Other Authors: Mukherjee, Soumya , Pramanik, Debajyoti , Mittra, Kaustuv , Dey, Abhishek , Dey, Somdatta Ghosh
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1364-548X ; DOI: 1364-548X ; DOI: 10.1039/c2cc37626a
Link: http://search.proquest.com/docview/1273386090/?pq-origsite=primo
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recordid: proquest1273386090
title: Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease.
format: Article
creator:
  • Seal, Manas
  • Mukherjee, Soumya
  • Pramanik, Debajyoti
  • Mittra, Kaustuv
  • Dey, Abhishek
  • Dey, Somdatta Ghosh
subjects:
  • Alzheimer Disease–Chemistry
  • Amyloid Beta-Peptides–Chemistry
  • Heme–Chemistry
  • Iron–Chemistry
  • Oxidation-Reduction–Chemistry
  • Oxygen–Chemistry
  • Amyloid Beta-Peptides
  • Heme
  • Iron
  • Oxygen
ispartof: Chemical communications (Cambridge, England), February 4, 2013, Vol.49(11), pp.1091-1093
description: Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O(2) in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe-O(2) intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Aβ peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.
language: eng
source:
identifier: E-ISSN: 1364-548X ; DOI: 1364-548X ; DOI: 10.1039/c2cc37626a
fulltext: fulltext
issn:
  • 1364548X
  • 1364-548X
url: Link


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descriptionRedox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O(2) in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe-O(2) intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Aβ peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.
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