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Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.

BACKGROUNDRecent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD). METHODSWe used 1,877 Caucasian cases and controls from the NIA-LOAD study and 1,093 Cari... Full description

Journal Title: PloS one 2012, Vol.7(12), p.e50354
Main Author: Reitz, Christiane
Other Authors: Tosto, Giuseppe , Mayeux, Richard , Luchsinger, Jose A , Reitz, Christiane , Weiner, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0050354
Link: http://search.proquest.com/docview/1283732679/?pq-origsite=primo
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title: Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.
format: Article
creator:
  • Reitz, Christiane
  • Tosto, Giuseppe
  • Mayeux, Richard
  • Luchsinger, Jose A
  • Reitz, Christiane
  • Weiner, Michael
subjects:
  • Aged–Genetics
  • Aged, 80 and Over–Genetics
  • Alleles–Genetics
  • Alpha-Ketoglutarate-Dependent Dioxygenase Fto–Genetics
  • Alzheimer Disease–Genetics
  • Case-Control Studies–Genetics
  • Endophenotypes–Genetics
  • European Continental Ancestry Group–Genetics
  • Female–Genetics
  • Gene Frequency–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Genome-Wide Association Study–Genetics
  • Genotype–Genetics
  • Hispanic Americans–Genetics
  • Humans–Genetics
  • Male–Genetics
  • Middle Aged–Genetics
  • Polymorphism, Single Nucleotide–Genetics
  • Proteins–Genetics
  • Proteins
  • Alpha-Ketoglutarate-Dependent Dioxygenase Fto
  • Fto Protein, Human
ispartof: PloS one, 2012, Vol.7(12), p.e50354
description: BACKGROUNDRecent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD). METHODSWe used 1,877 Caucasian cases and controls from the NIA-LOAD study and 1,093 Caribbean...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0050354
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleGenetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.
creatorReitz, Christiane ; Tosto, Giuseppe ; Mayeux, Richard ; Luchsinger, Jose A ; Reitz, Christiane ; Weiner, Michael
contributorAisen, Paul (correspondence author) ; Weiner, Michael (record owner) ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R ; Jagust, William ; Trojanowki, John Q ; Toga, Arthur W ; Beckett, Laurel ; Green, Robert C ; Saykin, Andrew J ; Morris, John ; Liu, Enchi ; Green, Robert C ; Montine, Tom ; Petersen, Ronald ; Aisen, Paul ; Gamst, Anthony ; Thomas, Ronald G ; Donohue, Michael ; Walter, Sarah ; Gessert, Devon ; Sather, Tamie ; Beckett, Laurel ; Harvey, Danielle ; Gamst, Anthony ; Donohue, Michael ; Kornak, John ; Jack, Clifford R ; Dale, Anders ; Bernstein, Matthew ; Felmlee, Joel ; Fox, Nick ; Thompson, Paul ; Schuff, Norbert ; Alexander, Gene ; Decarli, Charles ; Jagust, William ; Bandy, Dan ; Koeppe, Robert A ; Foster, Norm ; Reiman, Eric M ; Chen, Kewei ; Mathis, Chet ; Morris, John ; Cairns, Nigel J ; Taylor-Reinwald, Lisa ; Trojanowki, J Q ; Shaw, Les ; Lee, Virginia M Y ; Korecka, Magdalena ; Toga, Arthur W ; Crawford, Karen ; Neu, Scott ; Saykin, Andrew J ; Foroud, Tatiana M ; Potkin, Steven ; Shen, Li ; Kachaturian, Zaven ; Frank, Richard ; Snyder, Peter J ; Molchan, Susan ; Kaye, Jeffrey ; Quinn, Joseph ; Lind, Betty ; Dolen, Sara ; Schneider, Lon S ; Pawluczyk, Sonia ; Spann, Bryan M ; Brewer, James ; Vanderswag, Helen ; Heidebrink, Judith L ; Lord, Joanne L ; Petersen, Ronald ; Johnson, Kris ; Doody, Rachelle S ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Stern, Yaakov ; Honig, Lawrence S ; Bell, Karen L ; Morris, John C ; Ances, Beau ; Carroll, Maria ; Leon, Sue ; Mintun, Mark A ; Schneider, Stacy ; Marson, Daniel ; Griffith, Randall ; Clark, David ; Grossman, Hillel ; Mitsis, Effie ; Romirowsky, Aliza ; Detoledo-Morrell, Leyla ; Shah, Raj C ; Duara, Ranjan ; Varon, Daniel ; Roberts, Peggy ; Albert, Marilyn ; Onyike, Chiadi ; Kielb, Stephanie ; Rusinek, Henry ; de Leon, Mony J ; Glodzik, Lidia ; De Santi, Susan ; Doraiswamy, P Murali ; Petrella, Jeffrey R ; Coleman, R Edward ; Arnold, Steven E ; Karlawish, Jason H ; Wolk, David ; Smith, Charles D ; Jicha, Greg ; Hardy, Peter ; Lopez, Oscar L ; Oakley, Maryann ; Simpson, Donna M ; Porsteinsson, Anton P ; Goldstein, Bonnie S ; Martin, Kim ; Makino, Kelly M ; Ismail, M Saleem ; Brand, Connie ; Mulnard, Ruth A ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Womack, Kyle ; Mathews, Dana ; Quiceno, Mary ; Diaz-Arrastia, Ramon ; King, Richard ; Weiner, Myron ; Martin-Cook, Kristen ; Devous, Michael ; Levey, Allan I ; Lah, James J ; Cellar, Janet S ; Burns, Jeffrey M ; Anderson, Heather S ; Swerdlow, Russell H ; Apostolova, Liana ; Lu, Po H ; Bartzokis, George ; Silverman, Daniel H S ; Graff-Radford, Neill R ; Parfitt, Francine ; Johnson, Heather ; Farlow, Martin R ; Hake, Ann Marie ; Matthews, Brandy R ; Herring, Scott ; van Dyck, Christopher H ; Carson, Richard E ; Macavoy, Martha G ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Stefanovic, Bojana ; Curtis Caldwell, Curtis Caldwell ; Hsiung, Ging-Yuek Robin ; Feldman, Howard ; Mudge, Benita ; Assaly, Michele ; Kertesz, Andrew ; Rogers, John ; Trost, Dick ; Bernick, Charles ; Munic, Donna ; Kerwin, Diana ; Mesulam, Marek-Marsel ; Lipowski, Kristina ; Wu, Chuang-Kuo Wu ; Johnson, Nancy ; Sadowsky, Carl ; Martinez, Walter ; Villena, Teresa ; Turner, Raymond Scott ; Johnson, Kathleen ; Reynolds, Brigid ; Sperling, Reisa A ; Johnson, Keith A ; Marshall, Gad ; Frey, Meghan ; Yesavage, Jerome ; Taylor, Joy L ; Lane, Barton ; Rosen, Allyson ; Tinklenberg, Jared ; Sabbagh, Marwan ; Belden, Christine ; Jacobson, Sandra ; Kowall, Neil ; Killiany, Ronald ; Budson, Andrew E ; Norbash, Alexander ; Johnson, Patricia Lynn ; Obisesan, Thomas O ; Wolday, Saba ; Bwayo, Salome K ; Lerner, Alan ; Hudson, Leon ; Ogrocki, Paula ; Fletcher, Evan ; Carmichael, Owen ; Olichney, John ; Decarli, Charles ; Kittur, Smita ; Borrie, Michael ; Lee, T-Y ; Bartha, Rob ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia M ; Potkin, Steven G ; Preda, Adrian ; Nguyen, Dana ; Tariot, Pierre ; Fleisher, Adam ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Scharre, Douglas W ; Kataki, Maria ; Zimmerman, Earl A ; Celmins, Dzintra ; Brown, Alice D ; Pearlson, Godfrey D ; Blank, Karen ; Anderson, Karen ; Saykin, Andrew J ; Santulli, Robert B ; Schwartz, Eben S ; Sink, Kaycee M ; Williamson, Jeff D ; Garg, Pradeep ; Watkins, Franklin ; Ott, Brian R ; Querfurth, Henry ; Tremont, Geoffrey ; Salloway, Stephen ; Malloy, Paul ; Correia, Stephen
ispartofPloS one, 2012, Vol.7(12), p.e50354
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0050354
subjectAged–Genetics ; Aged, 80 and Over–Genetics ; Alleles–Genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase Fto–Genetics ; Alzheimer Disease–Genetics ; Case-Control Studies–Genetics ; Endophenotypes–Genetics ; European Continental Ancestry Group–Genetics ; Female–Genetics ; Gene Frequency–Genetics ; Genetic Predisposition to Disease–Genetics ; Genome-Wide Association Study–Genetics ; Genotype–Genetics ; Hispanic Americans–Genetics ; Humans–Genetics ; Male–Genetics ; Middle Aged–Genetics ; Polymorphism, Single Nucleotide–Genetics ; Proteins–Genetics ; Proteins ; Alpha-Ketoglutarate-Dependent Dioxygenase Fto ; Fto Protein, Human
descriptionBACKGROUNDRecent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD). METHODSWe used 1,877 Caucasian cases and controls from the NIA-LOAD study and 1,093 Caribbean...
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1Tosto, Giuseppe
2Mayeux, Richard
3Luchsinger, Jose A
4Weiner, Michael
titleGenetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.
descriptionBACKGROUNDRecent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD). METHODSWe used 1,877 Caucasian cases and controls from the NIA-LOAD study and 1,093 Caribbean...
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0Aged–Genetics
1Aged, 80 and Over–Genetics
2Alleles–Genetics
3Alpha-Ketoglutarate-Dependent Dioxygenase Fto–Genetics
4Alzheimer Disease–Genetics
5Case-Control Studies–Genetics
6Endophenotypes–Genetics
7European Continental Ancestry Group–Genetics
8Female–Genetics
9Gene Frequency–Genetics
10Genetic...
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1Weiner, Michael
2Petersen, Ronald
3Jack, Clifford R
4Jagust, William
5Trojanowki, John Q
6Toga, Arthur W
7Beckett, Laurel
8Green, Robert C
9Saykin, Andrew J
10Morris, John
11Liu, Enchi
12Montine, Tom
13Gamst, Anthony
14Thomas, Ronald G
15Donohue, Michael
16Walter, Sarah
17Gessert, Devon
18Sather, Tamie
19Harvey, Danielle
20Kornak, John
21Dale, Anders
22Bernstein, Matthew
23Felmlee, Joel
24Fox, Nick
25Thompson, Paul
26Schuff, Norbert
27Alexander, Gene
28Decarli, Charles
29Bandy, Dan
30Koeppe, Robert A
31Foster, Norm
32Reiman, Eric M
33Chen, Kewei
34Mathis, Chet
35Cairns, Nigel J
36Taylor-Reinwald, Lisa
37Trojanowki, J Q
38Shaw, Les
39Lee, Virginia M Y
40Korecka, Magdalena
41Crawford, Karen
42Neu, Scott
43Foroud, Tatiana M
44Potkin, Steven
45Shen, Li
46Kachaturian, Zaven
47Frank, Richard
48Snyder, Peter J
49Molchan, Susan
50Kaye, Jeffrey
51Quinn, Joseph
52Lind, Betty
53Dolen, Sara
54Schneider, Lon S
55Pawluczyk, Sonia
56Spann, Bryan M
57Brewer, James
58Vanderswag, Helen
59Heidebrink, Judith L
60Lord, Joanne L
61Johnson, Kris
62Doody, Rachelle S
63Villanueva-Meyer, Javier
64Chowdhury, Munir
65Stern, Yaakov
66Honig, Lawrence S
67Bell, Karen L
68Morris, John C
69Ances, Beau
70Carroll, Maria
71Leon, Sue
72Mintun, Mark A
73Schneider, Stacy
74Marson, Daniel
75Griffith, Randall
76Clark, David
77Grossman, Hillel
78Mitsis, Effie
79Romirowsky, Aliza
80Detoledo-Morrell, Leyla
81Shah, Raj C
82Duara, Ranjan
83Varon, Daniel
84Roberts, Peggy
85Albert, Marilyn
86Onyike, Chiadi
87Kielb, Stephanie
88Rusinek, Henry
89de Leon, Mony J
90Glodzik, Lidia
91De Santi, Susan
92Doraiswamy, P Murali
93Petrella, Jeffrey R
94Coleman, R Edward
95Arnold, Steven E
96Karlawish, Jason H
97Wolk, David
98Smith, Charles D
99Jicha, Greg
100...
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citationpf e50354 pt e50354 vol 7 issue 12
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titleGenetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.
authorReitz, Christiane ; Tosto, Giuseppe ; Mayeux, Richard ; Luchsinger, Jose A ; Reitz, Christiane ; Weiner, Michael
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1Aged, 80 and Over–Genetics
2Alleles–Genetics
3Alpha-Ketoglutarate-Dependent Dioxygenase Fto–Genetics
4Alzheimer Disease–Genetics
5Case-Control Studies–Genetics
6Endophenotypes–Genetics
7European Continental Ancestry Group–Genetics
8Female–Genetics
9Gene Frequency–Genetics
10Genetic...
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1Tosto, Giuseppe
2Mayeux, Richard
3Luchsinger, Jose A
4Weiner, Michael
5Aisen, Paul
6Petersen, Ronald
7Jack, Clifford R
8Jagust, William
9Trojanowki, John Q
10Toga, Arthur W
11Beckett, Laurel
12Green, Robert C
13Saykin, Andrew J
14Morris, John
15Liu, Enchi
16Montine, Tom
17Gamst, Anthony
18Thomas, Ronald G
19Donohue, Michael
20Walter, Sarah
21Gessert, Devon
22Sather, Tamie
23Harvey, Danielle
24Kornak, John
25Dale, Anders
26Bernstein, Matthew
27Felmlee, Joel
28Fox, Nick
29Thompson, Paul
30Schuff, Norbert
31Alexander, Gene
32Decarli, Charles
33Bandy, Dan
34Koeppe, Robert A
35Foster, Norm
36Reiman, Eric M
37Chen, Kewei
38Mathis, Chet
39Cairns, Nigel J
40Taylor-Reinwald, Lisa
41Trojanowki, J Q
42Shaw, Les
43Lee, Virginia M Y
44Korecka, Magdalena
45Crawford, Karen
46Neu, Scott
47Foroud, Tatiana M
48Potkin, Steven
49Shen, Li
50Kachaturian, Zaven
51Frank, Richard
52Snyder, Peter J
53Molchan, Susan
54Kaye, Jeffrey
55Quinn, Joseph
56Lind, Betty
57Dolen, Sara
58Schneider, Lon S
59Pawluczyk, Sonia
60Spann, Bryan M
61Brewer, James
62Vanderswag, Helen
63Heidebrink, Judith L
64Lord, Joanne L
65Johnson, Kris
66Doody, Rachelle S
67Villanueva-Meyer, Javier
68Chowdhury, Munir
69Stern, Yaakov
70Honig, Lawrence S
71Bell, Karen L
72Morris, John C
73Ances, Beau
74Carroll, Maria
75Leon, Sue
76Mintun, Mark A
77Schneider, Stacy
78Marson, Daniel
79Griffith, Randall
80Clark, David
81Grossman, Hillel
82Mitsis, Effie
83Romirowsky, Aliza
84Detoledo-Morrell, Leyla
85Shah, Raj C
86Duara, Ranjan
87Varon, Daniel
88Roberts, Peggy
89Albert, Marilyn
90Onyike, Chiadi
91Kielb, Stephanie
92Rusinek, Henry
93de Leon, Mony J
94Glodzik, Lidia
95De Santi, Susan
96Doraiswamy, P Murali
97Petrella, Jeffrey R
98Coleman, R Edward
99Arnold, Steven E
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8Green, Robert C
9Saykin, Andrew J
10Morris, John
11Liu, Enchi
12Montine, Tom
13Gamst, Anthony
14Thomas, Ronald G
15Donohue, Michael
16Walter, Sarah
17Gessert, Devon
18Sather, Tamie
19Harvey, Danielle
20Kornak, John
21Dale, Anders
22Bernstein, Matthew
23Felmlee, Joel
24Fox, Nick
25Thompson, Paul
26Schuff, Norbert
27Alexander, Gene
28DeCarli, Charles
29Bandy, Dan
30Koeppe, Robert A
31Foster, Norm
32Reiman, Eric M
33Chen, Kewei
34Mathis, Chet
35Cairns, Nigel J
36Taylor-Reinwald, Lisa
37Trojanowki, J Q
38Shaw, Les
39Lee, Virginia M Y
40Korecka, Magdalena
41Crawford, Karen
42Neu, Scott
43Foroud, Tatiana M
44Potkin, Steven
45Shen, Li
46Kachaturian, Zaven
47Frank, Richard
48Snyder, Peter J
49Molchan, Susan
50Kaye, Jeffrey
51Quinn, Joseph
52Lind, Betty
53Dolen, Sara
54Schneider, Lon S
55Pawluczyk, Sonia
56Spann, Bryan M
57Brewer, James
58Vanderswag, Helen
59Heidebrink, Judith L
60Lord, Joanne L
61Johnson, Kris
62Doody, Rachelle S
63Villanueva-Meyer, Javier
64Chowdhury, Munir
65Stern, Yaakov
66Honig, Lawrence S
67Bell, Karen L
68Morris, John C
69Ances, Beau
70Carroll, Maria
71Leon, Sue
72Mintun, Mark A
73Schneider, Stacy
74Marson, Daniel
75Griffith, Randall
76Clark, David
77Grossman, Hillel
78Mitsis, Effie
79Romirowsky, Aliza
80deToledo-Morrell, Leyla
81Shah, Raj C
82Duara, Ranjan
83Varon, Daniel
84Roberts, Peggy
85Albert, Marilyn
86Onyike, Chiadi
87Kielb, Stephanie
88Rusinek, Henry
89de Leon, Mony J
90Glodzik, Lidia
91De Santi, Susan
92Doraiswamy, P Murali
93Petrella, Jeffrey R
94Coleman, R Edward
95Arnold, Steven E
96Karlawish, Jason H
97Wolk, David
98Smith, Charles D
99Jicha, Greg
100...
atitleGenetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.
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risdate20120101
volume7
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abstractBACKGROUNDRecent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD). METHODSWe used 1,877 Caucasian cases and controls from the NIA-LOAD study and 1,093 Caribbean...
doi10.1371/journal.pone.0050354
urlhttp://search.proquest.com/docview/1283732679/
date2012-01-01