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Exploiting specific interactions toward next-generation polymeric drug transporters.

A generic method describes advanced tailoring of polymer drug carriers based on polymer-block-peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble a... Full description

Journal Title: Journal of the American Chemical Society February 6, 2013, Vol.135(5), pp.1711-1714
Main Author: Wieczorek, Sebastian
Other Authors: Krause, Eberhard , Hackbarth, Steffen , Röder, Beate , Hirsch, Anna K H , Börner, Hans G
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5126 ; DOI: 10.1021/ja311895z
Link: http://search.proquest.com/docview/1285080320/?pq-origsite=primo
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recordid: proquest1285080320
title: Exploiting specific interactions toward next-generation polymeric drug transporters.
format: Article
creator:
  • Wieczorek, Sebastian
  • Krause, Eberhard
  • Hackbarth, Steffen
  • Röder, Beate
  • Hirsch, Anna K H
  • Börner, Hans G
subjects:
  • Antineoplastic Agents–Chemistry
  • Drug Carriers–Chemistry
  • Mesoporphyrins–Chemistry
  • Models, Molecular–Chemistry
  • Molecular Structure–Genetics
  • Peptides–Chemistry
  • Photochemotherapy–Chemistry
  • Polymers–Chemistry
  • Antineoplastic Agents
  • Drug Carriers
  • Mesoporphyrins
  • Peptides
  • Polymers
  • Temoporfin
ispartof: Journal of the American Chemical Society, February 6, 2013, Vol.135(5), pp.1711-1714
description: A generic method describes advanced tailoring of polymer drug carriers based on polymer-block-peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble and enable precise adjustment of drug-release profiles beyond established block-copolymer carriers. While proof of principle is shown on chlorin as a partially approved drug for photodynamic cancer therapy, the concept is universal and applies to a broad spectrum of difficult drugs.
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 10.1021/ja311895z
fulltext: no_fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titleExploiting specific interactions toward next-generation polymeric drug transporters.
creatorWieczorek, Sebastian ; Krause, Eberhard ; Hackbarth, Steffen ; Röder, Beate ; Hirsch, Anna K H ; Börner, Hans G
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identifierE-ISSN: 1520-5126 ; DOI: 10.1021/ja311895z
subjectAntineoplastic Agents–Chemistry ; Drug Carriers–Chemistry ; Mesoporphyrins–Chemistry ; Models, Molecular–Chemistry ; Molecular Structure–Genetics ; Peptides–Chemistry ; Photochemotherapy–Chemistry ; Polymers–Chemistry ; Antineoplastic Agents ; Drug Carriers ; Mesoporphyrins ; Peptides ; Polymers ; Temoporfin
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