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Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly.

Leptin, a hormone produced by body fat tissue, acts on hypothalamic receptors in the brain to regulate appetite and energy expenditure, and on neurons in the arcuate nucleus to signal that an individual has had enough to eat. Leptin enters the central nervous system at levels that depend on an indiv... Full description

Journal Title: Neuroreport January 23, 2013, Vol.24(2), pp.58-62
Main Author: Rajagopalan, Priya
Other Authors: Toga, Arthur W , Jack, Clifford R , Weiner, Michael W , Thompson, Paul M , Rajagopalan, Priya
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1473-558X ; DOI: 10.1097/WNR.0b013e32835c5254
Link: http://search.proquest.com/docview/1285081234/?pq-origsite=primo
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title: Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly.
format: Article
creator:
  • Rajagopalan, Priya
  • Toga, Arthur W
  • Jack, Clifford R
  • Weiner, Michael W
  • Thompson, Paul M
  • Rajagopalan, Priya
subjects:
  • Adipose Tissue–Metabolism
  • Age Factors–Metabolism
  • Aged–Physiopathology
  • Aged, 80 and Over–Anatomy & Histology
  • Alzheimer Disease–Pathology
  • Body Mass Index–Physiopathology
  • Brain–Physiology
  • Energy Metabolism–Blood
  • Hormones–Metabolism
  • Humans–Blood
  • Leptin–Methods
  • Middle Aged–Blood
  • Neuroimaging–Metabolism
  • Obesity–Metabolism
  • Sex Factors–Metabolism
  • Hormones
  • Leptin
ispartof: Neuroreport, January 23, 2013, Vol.24(2), pp.58-62
description: Leptin, a hormone produced by body fat tissue, acts on hypothalamic receptors in the brain to regulate appetite and energy expenditure, and on neurons in the arcuate nucleus to signal that an individual has had enough to eat. Leptin enters the central nervous system at levels that depend on an individual's body fat. Obese people, on average, show greater brain atrophy in old age, so it is valuable to know whether brain atrophy relates to leptin levels, which can be targeted by interventions. We therefore determined how plasma leptin levels, and BMI, relate to brain structure, and whether leptin levels might account for BMI's effect on the brain. We measured regional brain volumes using tensor-based morphometry, in MRI scans of 517 elderly individuals with plasma leptin measured (mean: 13.3 plus or minus 0.6 ng/ml; mean age: 75.2 plus or minus 7.3 years; 321 men/196 women). We related plasma leptin levels to brain volumes at every location in the brain after adjusting for age, sex, and diagnosis and, later, also BMI. Plasma leptin levels were significantly higher (a) in women than men, and (b) in obese versus overweight, normal or underweight individuals. People with higher leptin levels showed deficits in frontal, parietal, temporal and occipital lobes, brainstem, and the cerebellum, irrespective of age, sex, or diagnosis. These associations persisted after controlling for BMI. Greater brain atrophy may occur in people with central leptin insufficiency, a marker of obesity. Therapeutic manipulation of leptin may be a promising direction for slowing brain decline.
language: eng
source:
identifier: E-ISSN: 1473-558X ; DOI: 10.1097/WNR.0b013e32835c5254
fulltext: fulltext
issn:
  • 1473558X
  • 1473-558X
url: Link


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titleFat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly.
creatorRajagopalan, Priya ; Toga, Arthur W ; Jack, Clifford R ; Weiner, Michael W ; Thompson, Paul M ; Rajagopalan, Priya
contributorWeiner, Michael (correspondence author) ; Aisen, Paul (record owner) ; Weiner, Michael ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R ; Jagust, William ; Trojanowki, John Q ; Toga, Arthur W ; Beckett, Laurel ; Green, Robert C ; Saykin, Andrew J ; Morris, John ; Liu, Enchi ; Green, Robert C ; Montine, Tom ; Petersen, Ronald ; Aisen, Paul ; Gamst, Anthony ; Thomas, Ronald G ; Donohue, Michael ; Walter, Sarah ; Gessert, Devon ; Sather, Tamie ; Beckett, Laurel ; Harvey, Danielle ; Gamst, Anthony ; Donohue, Michael ; Kornak, John ; Jack, Clifford R ; Anders, Dale ; Bernstein, Matthew ; Felmlee, Joel ; Fox, Nick ; Thompson, Paul ; Schuff, Norbert ; Alexander, Gene ; Decarli, Charles ; Jagust, William ; Bandy, Dan ; Koeppe, Robert A ; Foster, Norm ; Reiman, Eric M ; Chen, Kewei ; Mathis, Chet ; Morris, John ; Cairns, Nigel J ; Taylor-Reinwald, Lisa ; Trojanowki, J Q ; Shaw, Les ; Lee, Virginia M Y ; Korecka, Magdalena ; Toga, Arthur W ; Crawford, Karen ; Neu, Scott ; Saykin, Andrew J ; Foroud, Tatiana M ; Potkin, Steven ; Shen, Li ; Kachaturian, Zaven ; Frank, Richard ; Snyder, Peter J ; Molchan, Susan ; Kaye, Jeffrey ; Quinn, Joseph ; Lind, Betty ; Dolen, Sara ; Schneider, Lon S ; Pawluczyk, Sonia ; Spann, Bryan M ; Brewer, James ; Vanderswag, Helen ; Heidebrink, Judith L ; Lord, Joanne L ; Petersen, Ronald ; Johnson, Kris ; Doody, Rachelle S ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Stern, Yaakov ; Honig, Lawrence S ; Bell, Karen L ; Morris, John C ; Ances, Beau ; Carroll, Maria ; Leon, Sue ; Mintun, Mark A ; Schneider, Stacy ; Marson, Daniel ; Griffith, Randall ; Clark, David ; Grossman, Hillel ; Mitsis, Effie ; Romirowsky, Aliza ; de Toledo-Morrell, Leyla ; Shah, Raj C ; Duara, Ranjan ; Varon, Daniel ; Roberts, Peggy ; Albert, Marilyn ; Onyike, Chiadi ; Kielb, Stephanie ; Rusinek, Henry ; de Leon, Mony J ; Glodzik, Lidia ; De Santi, Susan ; Murali Doraiswamy, P ; Petrella, Jeffrey R ; Coleman, R Edward ; Arnold, Steven E ; Karlawish, Jason H ; Wolk, David ; Smith, Charles D ; Jicha, Greg ; Hardy, Peter ; Lopez, Oscar L ; Oakley, Maryann ; Simpson, Donna M ; Porsteinsson, Anton P ; Goldstein, Bonnie S ; Martin, Kim ; Makino, Kelly M ; Ismail, M Saleem ; Brand, Connie ; Mulnard, Ruth A ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Womack, Kyle ; Mathews, Dana ; Quiceno, Mary ; Diaz-Arrastia, Ramon ; King, Richard ; Weiner, Myron ; Martin-Cook, Kristen ; Devous, Michael ; Levey, Allan I ; Lah, James J ; Cellar, Janet S ; Burns, Jeffrey M ; Anderson, Heather S ; Swerdlow, Russell H ; Apostolova, Liana ; Lu, Po H ; Bartzokis, George ; Silverman, Daniel H S ; Graff-Radford, Neill R ; Parfitt, Francine ; Johnson, Heather ; Farlow, Martin R ; Hake, Ann Marie ; Matthews, Brandy R ; Herring, Scott ; van Dyck, Christopher H ; Carson, Richard E ; Macavoy, Martha G ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Stefanovic, Bojana ; Caldwell, Curtis ; Hsiung, Ging-Yuek Robin ; Feldman, Howard ; Mudge, Benita ; Assaly, Michele ; Kertesz, Andrew ; Rogers, John ; Trost, Dick ; Bernick, Charles ; Munic, Donna ; Kerwin, Diana ; Mesulam, Marek-Marsel ; Lipowski, Kristina ; Wu, Chuang-Kuo ; Johnson, Nancy ; Sadowsky, Carl ; Martinez, Walter ; Villena, Teresa ; Turner, Raymond Scott ; Johnson, Kathleen ; Reynolds, Brigid ; Sperling, Reisa A ; Johnson, Keith A ; Marshall, Gad ; Frey, Meghan ; Yesavage, Jerome ; Taylor, Joy L ; Lane, Barton ; Rosen, Allyson ; Tinklenberg, Jared ; Sabbagh, Marwan ; Belden, Christine ; Jacobson, Sandra ; Kowall, Neil ; Killiany, Ronald ; Budson, Andrew E ; Norbash, Alexander ; Johnson, Patricia Lynn ; Obisesan, Thomas O ; Wolday, Saba ; Bwayo, Salome K ; Lerner, Alan ; Hudson, Leon ; Ogrocki, Paula ; Fletcher, Evan ; Carmichael, Owen ; Olichney, John ; Decarli, Charles ; Kittur, Smita ; Borrie, Michael ; Lee, T-Y ; Bartha, Rob ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia M ; Potkin, Steven G ; Preda, Adrian ; Nguyen, Dana ; Tariot, Pierre ; Fleisher, Adam ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Scharre, Douglas W ; Kataki, Maria ; Zimmerman, Earl A ; Celmins, Dzintra ; Brown, Alice D ; Pearlson, Godfrey D ; Blank, Karen ; Anderson, Karen ; Saykin, Andrew J ; Santulli, Robert B ; Schwartz, Eben S ; Sink, Kaycee M ; Williamson, Jeff D ; Garg, Pradeep ; Watkins, Franklin ; Ott, Brian R ; Querfurth, Henry ; Tremont, Geoffrey ; Salloway, Stephen ; Malloy, Paul
ispartofNeuroreport, January 23, 2013, Vol.24(2), pp.58-62
identifierE-ISSN: 1473-558X ; DOI: 10.1097/WNR.0b013e32835c5254
subjectAdipose Tissue–Metabolism ; Age Factors–Metabolism ; Aged–Physiopathology ; Aged, 80 and Over–Anatomy & Histology ; Alzheimer Disease–Pathology ; Body Mass Index–Physiopathology ; Brain–Physiology ; Energy Metabolism–Blood ; Hormones–Metabolism ; Humans–Blood ; Leptin–Methods ; Middle Aged–Blood ; Neuroimaging–Metabolism ; Obesity–Metabolism ; Sex Factors–Metabolism ; Hormones ; Leptin
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descriptionLeptin, a hormone produced by body fat tissue, acts on hypothalamic receptors in the brain to regulate appetite and energy expenditure, and on neurons in the arcuate nucleus to signal that an individual has had enough to eat. Leptin enters the central nervous system at levels that depend on an individual's body fat. Obese people, on average, show greater brain atrophy in old age, so it is valuable to know whether brain atrophy relates to leptin levels, which can be targeted by interventions. We therefore determined how plasma leptin levels, and BMI, relate to brain structure, and whether leptin levels might account for BMI's effect on the brain. We measured regional brain volumes using tensor-based morphometry, in MRI scans of 517 elderly individuals with plasma leptin measured (mean: 13.3 plus or minus 0.6 ng/ml; mean age: 75.2 plus or minus 7.3 years; 321 men/196 women). We related plasma leptin levels to brain volumes at every location in the brain after adjusting for age, sex, and diagnosis and, later, also BMI. Plasma leptin levels were significantly higher (a) in women than men, and (b) in obese versus overweight, normal or underweight individuals. People with higher leptin levels showed deficits in frontal, parietal, temporal and occipital lobes, brainstem, and the cerebellum, irrespective of age, sex, or diagnosis. These associations persisted after controlling for BMI. Greater brain atrophy may occur in people with central leptin insufficiency, a marker of obesity. Therapeutic manipulation of leptin may be a promising direction for slowing brain decline.
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titleFat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly.
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1Age Factors–Metabolism
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3Aged, 80 and Over–Anatomy & Histology
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8Green, Robert C
9Saykin, Andrew J
10Morris, John
11Liu, Enchi
12Montine, Tom
13Gamst, Anthony
14Thomas, Ronald G
15Donohue, Michael
16Walter, Sarah
17Gessert, Devon
18Sather, Tamie
19Harvey, Danielle
20Kornak, John
21Anders, Dale
22Bernstein, Matthew
23Felmlee, Joel
24Fox, Nick
25Thompson, Paul
26Schuff, Norbert
27Alexander, Gene
28Decarli, Charles
29Bandy, Dan
30Koeppe, Robert A
31Foster, Norm
32Reiman, Eric M
33Chen, Kewei
34Mathis, Chet
35Cairns, Nigel J
36Taylor-Reinwald, Lisa
37Trojanowki, J Q
38Shaw, Les
39Lee, Virginia M Y
40Korecka, Magdalena
41Crawford, Karen
42Neu, Scott
43Foroud, Tatiana M
44Potkin, Steven
45Shen, Li
46Kachaturian, Zaven
47Frank, Richard
48Snyder, Peter J
49Molchan, Susan
50Kaye, Jeffrey
51Quinn, Joseph
52Lind, Betty
53Dolen, Sara
54Schneider, Lon S
55Pawluczyk, Sonia
56Spann, Bryan M
57Brewer, James
58Vanderswag, Helen
59Heidebrink, Judith L
60Lord, Joanne L
61Johnson, Kris
62Doody, Rachelle S
63Villanueva-Meyer, Javier
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titleFat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly.
authorRajagopalan, Priya ; Toga, Arthur W ; Jack, Clifford R ; Weiner, Michael W ; Thompson, Paul M ; Rajagopalan, Priya
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4Alzheimer Disease–Pathology
5Body Mass Index–Physiopathology
6Brain–Physiology
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9Humans–Blood
10Leptin–Methods
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8Jagust, William
9Trojanowki, John Q
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11Green, Robert C
12Saykin, Andrew J
13Morris, John
14Liu, Enchi
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16Gamst, Anthony
17Thomas, Ronald G
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30Alexander, Gene
31Decarli, Charles
32Bandy, Dan
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34Foster, Norm
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36Chen, Kewei
37Mathis, Chet
38Cairns, Nigel J
39Taylor-Reinwald, Lisa
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41Shaw, Les
42Lee, Virginia M Y
43Korecka, Magdalena
44Crawford, Karen
45Neu, Scott
46Foroud, Tatiana M
47Potkin, Steven
48Shen, Li
49Kachaturian, Zaven
50Frank, Richard
51Snyder, Peter J
52Molchan, Susan
53Kaye, Jeffrey
54Quinn, Joseph
55Lind, Betty
56Dolen, Sara
57Schneider, Lon S
58Pawluczyk, Sonia
59Spann, Bryan M
60Brewer, James
61Vanderswag, Helen
62Heidebrink, Judith L
63Lord, Joanne L
64Johnson, Kris
65Doody, Rachelle S
66Villanueva-Meyer, Javier
67Chowdhury, Munir
68Stern, Yaakov
69Honig, Lawrence S
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72Ances, Beau
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71Leon, Sue
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73Schneider, Stacy
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77Grossman, Hillel
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79Romirowsky, Aliza
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81Shah, Raj C
82Duara, Ranjan
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