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A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole

Background: The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus Aspergillus fumigatus. In a preliminary study, the extracts of Loxostylis alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumiga... Full description

Journal Title: BMC Veterinary Research 2012, Vol.8(1), p.210
Main Author: Suleiman, Mohammed
Other Authors: Duncan, Neil , Eloff, Jacobus , Naidoo, Vinny
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1746-6148 ; DOI: 10.1186/1746-6148-8-210
Link: http://search.proquest.com/docview/1285097775/
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title: A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole
format: Article
creator:
  • Suleiman, Mohammed
  • Duncan, Neil
  • Eloff, Jacobus
  • Naidoo, Vinny
subjects:
  • Antifungal Agents
  • Poultry
  • Leaves
  • Aspergillosis
  • Acute Toxicity
  • Plant Extracts
  • Acetone
  • Ketoconazole
  • Minimum Inhibitory Concentration
  • Models
  • Anacardiaceae
  • Aspergillus Fumigatus
  • Gallus
  • Animal Diseases
  • Loxostylis Alata
  • Aspergillosis
  • Broiler Chicks
ispartof: BMC Veterinary Research, 2012, Vol.8(1), p.210
description: Background: The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus Aspergillus fumigatus. In a preliminary study, the extracts of Loxostylis alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumigatus with a minimum inhibitory concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of L. alata leaves was evaluated for its acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis (A. fumigatus). Results: At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg. Conclusions: The results indicate that a crude extract of L. alata leaves has potential as an antifungal agent to protect poultry against avian aspergillosis.
language: eng
source:
identifier: ISSN: 1746-6148 ; DOI: 10.1186/1746-6148-8-210
fulltext: fulltext
issn:
  • 17466148
  • 1746-6148
url: Link


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titleA controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole
creatorSuleiman, Mohammed ; Duncan, Neil ; Eloff, Jacobus ; Naidoo, Vinny
contributorSuleiman, Mohammed (correspondence author)
ispartofBMC Veterinary Research, 2012, Vol.8(1), p.210
identifierISSN: 1746-6148 ; DOI: 10.1186/1746-6148-8-210
subjectAntifungal Agents ; Poultry ; Leaves ; Aspergillosis ; Acute Toxicity ; Plant Extracts ; Acetone ; Ketoconazole ; Minimum Inhibitory Concentration ; Models ; Anacardiaceae ; Aspergillus Fumigatus ; Gallus ; Animal Diseases ; Loxostylis Alata ; Aspergillosis ; Broiler Chicks
descriptionBackground: The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus Aspergillus fumigatus. In a preliminary study, the extracts of Loxostylis alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumigatus with a minimum inhibitory concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of L. alata leaves was evaluated for its acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis (A. fumigatus). Results: At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg. Conclusions: The results indicate that a crude extract of L. alata leaves has potential as an antifungal agent to protect poultry against avian aspergillosis.
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descriptionBackground: The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus Aspergillus fumigatus. In a preliminary study, the extracts of Loxostylis alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumigatus with a minimum inhibitory concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of L. alata leaves was evaluated for its acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis (A. fumigatus). Results: At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg. Conclusions: The results indicate that a crude extract of L. alata leaves has potential as an antifungal agent to protect poultry against avian aspergillosis.
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abstractBackground: The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus Aspergillus fumigatus. In a preliminary study, the extracts of Loxostylis alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumigatus with a minimum inhibitory concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of L. alata leaves was evaluated for its acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis (A. fumigatus). Results: At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg. Conclusions: The results indicate that a crude extract of L. alata leaves has potential as an antifungal agent to protect poultry against avian aspergillosis.
doi10.1186/1746-6148-8-210
urlhttp://search.proquest.com/docview/1285097775/
date2012-01-01