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Photoinduced electron transfer of DNA/Ag nanoclusters modulated by G-quadruplex/hemin complex for the construction of versatile biosensors.

Photoinduced electron transfer (PET) has been observed for the first time between DNA/Ag fluorescent nanoclusters (NCs) and G-quadruplex/hemin complexes, accompanied by a decrease in the fluorescence of the DNA/Ag NCs. In this PET process, a parallel G-quadruplex and the sensing sequences are blocke... Full description

Journal Title: Journal of the American Chemical Society February 20, 2013, Vol.135(7), pp.2403-2406
Main Author: Zhang, Libing
Other Authors: Zhu, Jinbo , Guo, Shaojun , Li, Tao , Li, Jing , Wang, Erkang
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
ID: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja3089857
Link: http://search.proquest.com/docview/1291599005/?pq-origsite=primo
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title: Photoinduced electron transfer of DNA/Ag nanoclusters modulated by G-quadruplex/hemin complex for the construction of versatile biosensors.
format: Article
creator:
  • Zhang, Libing
  • Zhu, Jinbo
  • Guo, Shaojun
  • Li, Tao
  • Li, Jing
  • Wang, Erkang
subjects:
  • Biosensing Techniques–Chemistry
  • DNA–Chemistry
  • Electron Transport–Chemistry
  • Fluorescent Dyes–Chemistry
  • G-Quadruplexes–Chemistry
  • Hemin–Chemistry
  • Metal Nanoparticles–Chemistry
  • Silver–Chemistry
  • Fluorescent Dyes
  • Silver
  • Hemin
  • DNA
ispartof: Journal of the American Chemical Society, February 20, 2013, Vol.135(7), pp.2403-2406
description: Photoinduced electron transfer (PET) has been observed for the first time between DNA/Ag fluorescent nanoclusters (NCs) and G-quadruplex/hemin complexes, accompanied by a decrease in the fluorescence of the DNA/Ag NCs. In this PET process, a parallel G-quadruplex and the sensing sequences are blocked by a duplex. The specific combination of targets with the sensing sequence triggers the release of the G-quadruplex and allows it to fold properly and bind hemin to form a stable G-quadruplex/hemin complex. The complex proves favorable for PET because it makes the G-quadruplex bind hemin tightly, which promotes the electron transfer from the DNA/Ag NCs to the hemin Fe(III) center, thus resulting in a decrease in the fluorescence intensity of the DNA/Ag NCs. This novel PET system enables the specific and versatile detection of target biomolecules such as DNA and ATP with high sensitivity based on the choices of different target sequences.
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja3089857
fulltext: no_fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titlePhotoinduced electron transfer of DNA/Ag nanoclusters modulated by G-quadruplex/hemin complex for the construction of versatile biosensors.
creatorZhang, Libing ; Zhu, Jinbo ; Guo, Shaojun ; Li, Tao ; Li, Jing ; Wang, Erkang
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descriptionPhotoinduced electron transfer (PET) has been observed for the first time between DNA/Ag fluorescent nanoclusters (NCs) and G-quadruplex/hemin complexes, accompanied by a decrease in the fluorescence of the DNA/Ag NCs. In this PET process, a parallel G-quadruplex and the sensing sequences are blocked by a duplex. The specific combination of targets with the sensing sequence triggers the release of the G-quadruplex and allows it to fold properly and bind hemin to form a stable G-quadruplex/hemin complex. The complex proves favorable for PET because it makes the G-quadruplex bind hemin tightly, which promotes the electron transfer from the DNA/Ag NCs to the hemin Fe(III) center, thus resulting in a decrease in the fluorescence intensity of the DNA/Ag NCs. This novel PET system enables the specific and versatile detection of target biomolecules such as DNA and ATP with high sensitivity based on the choices of different target sequences.
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