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Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.

BACKGROUNDHuman immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes. METHODSWe used data from the Concerted Action... Full description

Journal Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America March 2013, Vol.56(6), pp.888-897
Main Author: Touloumi, Giota
Other Authors: Pantazis, Nikos , Pillay, Deenan , Paraskevis, Dimitrios , Chaix, Marie-Laure , Bucher, Heiner C , Kücherer, Claudia , Zangerle, Robert , Kran, Anne-Marte Bakken , Porter, Kholoud , Touloumi, Giota
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1537-6591 ; DOI: 10.1093/cid/cis1000
Link: http://search.proquest.com/docview/1313422252/?pq-origsite=primo
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title: Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.
format: Article
creator:
  • Touloumi, Giota
  • Pantazis, Nikos
  • Pillay, Deenan
  • Paraskevis, Dimitrios
  • Chaix, Marie-Laure
  • Bucher, Heiner C
  • Kücherer, Claudia
  • Zangerle, Robert
  • Kran, Anne-Marte Bakken
  • Porter, Kholoud
  • Touloumi, Giota
subjects:
  • Adult–Therapeutic Use
  • Anti-HIV Agents–Epidemiology
  • Cd4 Lymphocyte Count–Drug Therapy
  • Europe–Epidemiology
  • Female–Virology
  • Genotype–Classification
  • HIV Infections–Genetics
  • HIV Seropositivity–Isolation & Purification
  • HIV-1–Isolation & Purification
  • Humans–Isolation & Purification
  • Male–Isolation & Purification
  • Middle Aged–Isolation & Purification
  • Molecular Epidemiology–Isolation & Purification
  • Treatment Outcome–Isolation & Purification
  • Viral Load–Isolation & Purification
  • Anti-HIV Agents
ispartof: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, March 2013, Vol.56(6), pp.888-897
description: BACKGROUNDHuman immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes. METHODSWe used data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration, restricted to those infected since 1996, aged ≥15 years, and applied mixed effects models for CD4 cell count decline and median regression for viral load set point (mean level 6-24 months from seroconversion). RESULTSThe analysis included 3364 seroconverters with known HIV-1 subtypes. Compared with subtype B, CD4 at seroconversion was significantly higher for subtype CRF01 and lower for subtype C. Subsequent CD4 decline was significantly slower for subtypes A and CRF02 and marginally slower for subtype C compared with B. Mean CD4 loss at 2 years of seroconversion for white men exposed through sex between men, aged 30-39 years, having seroconverted since 2006, enrolled within 6 months of seroconversion, and without acute infection was 88, 142, 100, 130, 103, and 167 cells/µL for subtypes A, B, C, CRF01_AE, CRF02_AG, and G, respectively. In adjusted analysis, median viral load set point and time to clinical AIDS/death did not differ significantly by subtype, although all subtypes, except C, tended to have lower levels compared with B. CONCLUSIONSHIV-1 subtype significantly influences seroconversion CD4 cell levels and decline rates but not viral load set point. These findings may be helpful to HIV-positive individuals and their attending physicians in understanding disease progression.
language: eng
source:
identifier: E-ISSN: 1537-6591 ; DOI: 10.1093/cid/cis1000
fulltext: fulltext
issn:
  • 15376591
  • 1537-6591
url: Link


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titleImpact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.
creatorTouloumi, Giota ; Pantazis, Nikos ; Pillay, Deenan ; Paraskevis, Dimitrios ; Chaix, Marie-Laure ; Bucher, Heiner C ; Kücherer, Claudia ; Zangerle, Robert ; Kran, Anne-Marte Bakken ; Porter, Kholoud ; Touloumi, Giota
contributorDel Amo, Julia (correspondence author) ; Meyer, Laurence (record owner) ; Bucher, Heiner C ; Chêne, Geneviève ; Hamouda, Osamah ; Pillay, Deenan ; Prins, Maria ; Rosinska, Magdalena ; Sabin, Caroline ; Touloumi, Giota ; Porter, Kholoud ; Olson, Ashley ; Coughlin, Kate ; Walker, Sarah ; Babiker, Abdel ; Bucher, Heiner C ; De Luca, Andrea ; Fisher, Martin ; Muga, Roberto ; Zangerle, Robert ; Kelleher, A D ; Cooper, D A ; Grey, Pat ; Finlayson, Robert ; Bloch, Mark ; Kelleher, Tony ; Ramacciotti, Tim ; Gelgor, Linda ; Cooper, David ; Smith, Don ; Gill, John ; Jørgensen, Louise Bruun ; Lutsar, Irja ; Chêne, Geneviève ; Dabis, Francois ; Thiebaut, Rodolphe ; Masquelier, Bernard ; Costagliola, Dominique ; Guiguet, Marguerite ; Vanhems, Philippe ; Chaix, Marie-Laure ; Ghosn, Jade ; Goujard, Cécile ; Meyer, Laurence ; Boufassa, Faroudy ; Hamouda, Osamah ; Kücherer, Claudia ; Bartmeyer, Barbara ; Touloumi, Giota ; Pantazis, Nikos ; Katsarou, Olga ; Paparizos, V ; Gargalianos-Kakolyris, P ; Lazanas, M ; Rezza, Giovanni ; Dorrucci, Maria ; Monforte, Antonella D'Arminio ; De Luca, Andrea ; Prins, Maria ; Geskus, Ronald ; van Der Helm, Jannie ; Schuitemaker, Hanneke ; Sannes, Mette ; Brubakk, Oddbjorn ; Kran, Anne-Marte Bakken ; Rosinska, Magdalena ; Muga, Roberto ; Tor, Jordi ; Garcia de Olalla, Patricia ; Cayla, Joan ; Del Amo, Julia ; Moreno, Santiago ; Monge, Susana ; Del Romero, Jorge ; Pérez-Hoyos, Santiago ; Rickenbach, Martin ; Francioli, Patrick ; Malyuta, Ruslan ; Brettle, Ray ; Murphy, Gary ; Johnson, Anne ; Phillips, Andrew ; Delpech, Valerie ; Morrison, Charles ; Salata, Robert ; Mugerwa, Roy ; Chipato, Tsungai ; Amornkul, Pauli ; Bucher, Heiner ; Burns, Fiona ; Chêne, Geneviève ; Costagliola, Dominique ; Giaquinto, Carlo ; Gibb, Di ; Grarup, Jesper ; Kirk, Ole ; Kjaer, Jesper ; Meyer, Laurence ; Panteleev, Alex ; Phillips, Andrew ; Porter, Kholoud ; Reiss, Peter ; Thorne, Claire ; Aboulker, Jean-Pierre ; Albert, Jan ; Asandi, Silvia ; Chêne, Geneviève ; Costagliola, Dominique ; Monforte, Antonella D'Arminio ; De Wit, Stéphane ; De Wolf, Frank ; Del Amo, Julia ; Gatell, José ; Giaquinto, Carlo ; Hamouda, Osamah ; Karpov, Igor ; Ledergerber, Bruno ; Lundgren, Jens ; Malyuta, Ruslan ; Møller, Claus ; Phillips, Andrew ; Porter, Kholoud ; Prins, Maria ; Rakhmanova, Aza ; Rockstroh, Jürgen ; Rosinska, Magda ; Thorne, Claire ; Touloumi, Giota ; Anne, Alain Volny ; Cooper, David ; Dedes, Nikos ; Fenton, Kevin ; Pizzuti, David ; Vitoria, Marco ; Coughlin, Kate ; Faggion, Silvia ; Fradette, Lorraine ; Frost, Richard ; Sabin, Miriam ; Schwimmer, Christine ; Scott, Martin ; Scott, Martin ; Scott, Martin
ispartofClinical infectious diseases : an official publication of the Infectious Diseases Society of America, March 2013, Vol.56(6), pp.888-897
identifierE-ISSN: 1537-6591 ; DOI: 10.1093/cid/cis1000
subject
descriptionBACKGROUNDHuman immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes. METHODSWe used data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration, restricted to those infected since 1996, aged ≥15 years, and applied mixed effects models for CD4 cell count decline and median regression for viral load set point (mean level 6-24 months from seroconversion). RESULTSThe analysis included 3364 seroconverters with known HIV-1 subtypes. Compared with subtype B, CD4 at seroconversion was significantly higher for subtype CRF01 and lower for subtype C. Subsequent CD4 decline was significantly slower for subtypes A and CRF02 and marginally slower for subtype C compared with B. Mean CD4 loss at 2 years of seroconversion for white men exposed through sex between men, aged 30-39 years, having seroconverted since 2006, enrolled within 6 months of seroconversion, and without acute infection was 88, 142, 100, 130, 103, and 167 cells/µL for subtypes A, B, C, CRF01_AE, CRF02_AG, and G, respectively. In adjusted analysis, median viral load set point and time to clinical AIDS/death did not differ significantly by subtype, although all subtypes, except C, tended to have lower levels compared with B. CONCLUSIONSHIV-1 subtype significantly influences seroconversion CD4 cell levels and decline rates but not viral load set point. These findings may be helpful to HIV-positive individuals and their attending physicians in understanding disease progression.
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1Pantazis, Nikos
2Pillay, Deenan
3Paraskevis, Dimitrios
4Chaix, Marie-Laure
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6Kücherer, Claudia
7Zangerle, Robert
8Kran, Anne-Marte Bakken
9Porter, Kholoud
titleImpact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.
descriptionBACKGROUNDHuman immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes. METHODSWe used data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration, restricted to those infected since 1996, aged ≥15 years, and applied mixed effects models for CD4 cell count decline and median regression for viral load set point (mean level 6-24 months from seroconversion). RESULTSThe analysis included 3364 seroconverters with known HIV-1 subtypes. Compared with subtype B, CD4 at seroconversion was significantly higher for subtype CRF01 and lower for subtype C. Subsequent CD4 decline was significantly slower for subtypes A and CRF02 and marginally slower for subtype C compared with B. Mean CD4 loss at 2 years of seroconversion for white men exposed through sex between men, aged 30-39 years, having seroconverted since 2006, enrolled within 6 months of seroconversion, and without acute infection was 88, 142, 100, 130, 103, and 167 cells/µL for subtypes A, B, C, CRF01_AE, CRF02_AG, and G, respectively. In adjusted analysis, median viral load set point and time to clinical AIDS/death did not differ significantly by subtype, although all subtypes, except C, tended to have lower levels compared with B. CONCLUSIONSHIV-1 subtype significantly influences seroconversion CD4 cell levels and decline rates but not viral load set point. These findings may be helpful to HIV-positive individuals and their attending physicians in understanding disease progression.
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1Anti-HIV Agents–Epidemiology
2Cd4 Lymphocyte Count–Drug Therapy
3Europe–Epidemiology
4Female–Virology
5Genotype–Classification
6HIV Infections–Genetics
7HIV Seropositivity–Isolation & Purification
8HIV-1–Isolation & Purification
9Humans–Isolation & Purification
10Male–Isolation & Purification
11Middle Aged–Isolation & Purification
12Molecular Epidemiology–Isolation & Purification
13Treatment Outcome–Isolation & Purification
14Viral Load–Isolation & Purification
15Anti-HIV Agents
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1Meyer, Laurence
2Bucher, Heiner C
3Chêne, Geneviève
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6Prins, Maria
7Rosinska, Magdalena
8Sabin, Caroline
9Touloumi, Giota
10Porter, Kholoud
11Olson, Ashley
12Coughlin, Kate
13Walker, Sarah
14Babiker, Abdel
15De Luca, Andrea
16Fisher, Martin
17Muga, Roberto
18Zangerle, Robert
19Kelleher, A D
20Cooper, D A
21Grey, Pat
22Finlayson, Robert
23Bloch, Mark
24Kelleher, Tony
25Ramacciotti, Tim
26Gelgor, Linda
27Cooper, David
28Smith, Don
29Gill, John
30Jørgensen, Louise Bruun
31Lutsar, Irja
32Dabis, Francois
33Thiebaut, Rodolphe
34Masquelier, Bernard
35Costagliola, Dominique
36Guiguet, Marguerite
37Vanhems, Philippe
38Chaix, Marie-Laure
39Ghosn, Jade
40Goujard, Cécile
41Boufassa, Faroudy
42Kücherer, Claudia
43Bartmeyer, Barbara
44Pantazis, Nikos
45Katsarou, Olga
46Paparizos, V
47Gargalianos-Kakolyris, P
48Lazanas, M
49Rezza, Giovanni
50Dorrucci, Maria
51Monforte, Antonella D'Arminio
52Geskus, Ronald
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54Schuitemaker, Hanneke
55Sannes, Mette
56Brubakk, Oddbjorn
57Kran, Anne-Marte Bakken
58Tor, Jordi
59Garcia de Olalla, Patricia
60Cayla, Joan
61Moreno, Santiago
62Monge, Susana
63Del Romero, Jorge
64Pérez-Hoyos, Santiago
65Rickenbach, Martin
66Francioli, Patrick
67Malyuta, Ruslan
68Brettle, Ray
69Murphy, Gary
70Johnson, Anne
71Phillips, Andrew
72Delpech, Valerie
73Morrison, Charles
74Salata, Robert
75Mugerwa, Roy
76Chipato, Tsungai
77Amornkul, Pauli
78Bucher, Heiner
79Burns, Fiona
80Giaquinto, Carlo
81Gibb, Di
82Grarup, Jesper
83Kirk, Ole
84Kjaer, Jesper
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96Lundgren, Jens
97Møller, Claus
98Rakhmanova, Aza
99Rockstroh, Jürgen
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titleImpact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.
authorTouloumi, Giota ; Pantazis, Nikos ; Pillay, Deenan ; Paraskevis, Dimitrios ; Chaix, Marie-Laure ; Bucher, Heiner C ; Kücherer, Claudia ; Zangerle, Robert ; Kran, Anne-Marte Bakken ; Porter, Kholoud ; Touloumi, Giota
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1Anti-HIV Agents–Epidemiology
2Cd4 Lymphocyte Count–Drug Therapy
3Europe–Epidemiology
4Female–Virology
5Genotype–Classification
6HIV Infections–Genetics
7HIV Seropositivity–Isolation & Purification
8HIV-1–Isolation & Purification
9Humans–Isolation & Purification
10Male–Isolation & Purification
11Middle Aged–Isolation & Purification
12Molecular Epidemiology–Isolation & Purification
13Treatment Outcome–Isolation & Purification
14Viral Load–Isolation & Purification
15Anti-HIV Agents
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1Pantazis, Nikos
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6Kücherer, Claudia
7Zangerle, Robert
8Kran, Anne-Marte Bakken
9Porter, Kholoud
10Del Amo, Julia
11Meyer, Laurence
12Chêne, Geneviève
13Hamouda, Osamah
14Prins, Maria
15Rosinska, Magdalena
16Sabin, Caroline
17Olson, Ashley
18Coughlin, Kate
19Walker, Sarah
20Babiker, Abdel
21De Luca, Andrea
22Fisher, Martin
23Muga, Roberto
24Kelleher, A D
25Cooper, D A
26Grey, Pat
27Finlayson, Robert
28Bloch, Mark
29Kelleher, Tony
30Ramacciotti, Tim
31Gelgor, Linda
32Cooper, David
33Smith, Don
34Gill, John
35Jørgensen, Louise Bruun
36Lutsar, Irja
37Dabis, Francois
38Thiebaut, Rodolphe
39Masquelier, Bernard
40Costagliola, Dominique
41Guiguet, Marguerite
42Vanhems, Philippe
43Ghosn, Jade
44Goujard, Cécile
45Boufassa, Faroudy
46Bartmeyer, Barbara
47Katsarou, Olga
48Paparizos, V
49Gargalianos-Kakolyris, P
50Lazanas, M
51Rezza, Giovanni
52Dorrucci, Maria
53Monforte, Antonella D'Arminio
54Geskus, Ronald
55van Der Helm, Jannie
56Schuitemaker, Hanneke
57Sannes, Mette
58Brubakk, Oddbjorn
59Tor, Jordi
60Garcia de Olalla, Patricia
61Cayla, Joan
62Moreno, Santiago
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70Murphy, Gary
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76Mugerwa, Roy
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62Moreno, Santiago
63Monge, Susana
64del Romero, Jorge
65Pérez-Hoyos, Santiago
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86Panteleev, Alex
87Reiss, Peter
88Thorne, Claire
89Aboulker, Jean-Pierre
90Albert, Jan
91Asandi, Silvia
92De Wit, Stéphane
93De Wolf, Frank
94Gatell, José
95Karpov, Igor
96Ledergerber, Bruno
97Lundgren, Jens
98Møller, Claus
99Rakhmanova, Aza
100...
atitleImpact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts.
jtitleClinical infectious diseases : an official publication of the Infectious Diseases Society of America
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abstractBACKGROUNDHuman immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes. METHODSWe used data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration, restricted to those infected since 1996, aged ≥15 years, and applied mixed effects models for CD4 cell count decline and median regression for viral load set point (mean level 6-24 months from seroconversion). RESULTSThe analysis included 3364 seroconverters with known HIV-1 subtypes. Compared with subtype B, CD4 at seroconversion was significantly higher for subtype CRF01 and lower for subtype C. Subsequent CD4 decline was significantly slower for subtypes A and CRF02 and marginally slower for subtype C compared with B. Mean CD4 loss at 2 years of seroconversion for white men exposed through sex between men, aged 30-39 years, having seroconverted since 2006, enrolled within 6 months of seroconversion, and without acute infection was 88, 142, 100, 130, 103, and 167 cells/µL for subtypes A, B, C, CRF01_AE, CRF02_AG, and G, respectively. In adjusted analysis, median viral load set point and time to clinical AIDS/death did not differ significantly by subtype, although all subtypes, except C, tended to have lower levels compared with B. CONCLUSIONSHIV-1 subtype significantly influences seroconversion CD4 cell levels and decline rates but not viral load set point. These findings may be helpful to HIV-positive individuals and their attending physicians in understanding disease progression.
doi10.1093/cid/cis1000
urlhttp://search.proquest.com/docview/1313422252/
issn10584838
date2013-03-01