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Proton T1 relaxation times of metabolites in human occipital white and gray matter at 7 T

Proton T1 relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T1 values of CH3 and CH2 group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in occipital white matter and gray matter at 7 T using a... Full description

Journal Title: Magnetic Resonance in Medicine Apr 2013, Vol.69(4), pp.931-6
Main Author: Xin, Lijing
Other Authors: Schaller, Benoît , Mlynarik, Vladimir , Lu, Huanxiang , Gruetter, Rolf
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 07403194 ; E-ISSN: 15222594 ; DOI: 10.1002/mrm.24352
Link: http://search.proquest.com/docview/1317988585/?pq-origsite=primo
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title: Proton T1 relaxation times of metabolites in human occipital white and gray matter at 7 T
format: Article
creator:
  • Xin, Lijing
  • Schaller, Benoît
  • Mlynarik, Vladimir
  • Lu, Huanxiang
  • Gruetter, Rolf
subjects:
  • Adult–Methods
  • Algorithms–Methods
  • Female–Metabolism
  • Humans–Metabolism
  • Magnetic Resonance Spectroscopy–Metabolism
  • Male–Diagnostic Use
  • Molecular Imaging–Diagnostic Use
  • Nerve Fibers, Myelinated–Diagnostic Use
  • Neurons–Diagnostic Use
  • Occipital Lobe–Diagnostic Use
  • Protons–Diagnostic Use
  • Young Adult–Diagnostic Use
  • Protons
ispartof: Magnetic Resonance in Medicine, Apr 2013, Vol.69(4), pp.931-6
description: Proton T1 relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T1 values of CH3 and CH2 group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in occipital white matter and gray matter at 7 T using an inversion-recovery technique combined with a newly implemented semi-adiabatic spin-echo full-intensity acquired localized spectroscopy sequence (echo time = 12 ms). The mean T1 values of metabolites in occipital white matter and gray matter ranged from 0.9 to 2.2 s. Among them, the T1 of glutathione, scyllo-inositol, taurine, phosphorylethanolamine, and N-acetylaspartylglutamate were determined for the first time in the human brain. Significant differences in T1 between white matter and gray matter were found for water (-28%), total choline (-14%), N-acetylaspartylglutamate (-29%), N-acetylaspartate (+4%), and glutamate (+8%). An increasing trend in T1 was observed when compared with previously...
language: eng
source:
identifier: ISSN: 07403194 ; E-ISSN: 15222594 ; DOI: 10.1002/mrm.24352
fulltext: fulltext
issn:
  • 07403194
  • 0740-3194
  • 15222594
  • 1522-2594
url: Link


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titleProton T1 relaxation times of metabolites in human occipital white and gray matter at 7 T
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subjectAdult–Methods ; Algorithms–Methods ; Female–Metabolism ; Humans–Metabolism ; Magnetic Resonance Spectroscopy–Metabolism ; Male–Diagnostic Use ; Molecular Imaging–Diagnostic Use ; Nerve Fibers, Myelinated–Diagnostic Use ; Neurons–Diagnostic Use ; Occipital Lobe–Diagnostic Use ; Protons–Diagnostic Use ; Young Adult–Diagnostic Use ; Protons
descriptionProton T1 relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T1 values of CH3 and CH2 group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in occipital white matter and gray matter at 7 T using an inversion-recovery technique combined with a newly implemented semi-adiabatic spin-echo full-intensity acquired localized spectroscopy sequence (echo time = 12 ms). The mean T1 values of metabolites in occipital white matter and gray matter ranged from 0.9 to 2.2 s. Among them, the T1 of glutathione, scyllo-inositol, taurine, phosphorylethanolamine, and N-acetylaspartylglutamate were determined for the first time in the human brain. Significant differences in T1 between white matter and gray matter were found for water (-28%), total choline (-14%), N-acetylaspartylglutamate (-29%), N-acetylaspartate (+4%), and glutamate (+8%). An increasing trend in T1 was observed when compared with previously...
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descriptionProton T1 relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T1 values of CH3 and CH2 group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in occipital white matter and gray matter at 7 T using an inversion-recovery technique combined with a newly implemented semi-adiabatic spin-echo full-intensity acquired localized spectroscopy sequence (echo time = 12 ms). The mean T1 values of metabolites in occipital white matter and gray matter ranged from 0.9 to 2.2 s. Among them, the T1 of glutathione, scyllo-inositol, taurine, phosphorylethanolamine, and N-acetylaspartylglutamate were determined for the first time in the human brain. Significant differences in T1 between white matter and gray matter were found for water (-28%), total choline (-14%), N-acetylaspartylglutamate (-29%), N-acetylaspartate (+4%), and glutamate (+8%). An increasing trend in T1 was observed when compared with previously...
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titleProton T1 relaxation times of metabolites in human occipital white and gray matter at 7 T
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abstractProton T1 relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T1 values of CH3 and CH2 group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in occipital white matter and gray matter at 7 T using an inversion-recovery technique combined with a newly implemented semi-adiabatic spin-echo full-intensity acquired localized spectroscopy sequence (echo time = 12 ms). The mean T1 values of metabolites in occipital white matter and gray matter ranged from 0.9 to 2.2 s. Among them, the T1 of glutathione, scyllo-inositol, taurine, phosphorylethanolamine, and N-acetylaspartylglutamate were determined for the first time in the human brain. Significant differences in T1 between white matter and gray matter were found for water (-28%), total choline (-14%), N-acetylaspartylglutamate (-29%), N-acetylaspartate (+4%), and glutamate (+8%). An increasing trend in T1 was observed when compared with previously...
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date2013-04-01