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Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies1-4

Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) assoc... Full description

Journal Title: The Journal of Nutrition Mar 2013, Vol.143(3), pp.345-53
Main Author: Hruby, Adela
Other Authors: Ngwa, Julius , Renström, Frida , Wojczynski, Mary , Ganna, Andrea , Hallmans, Göran , Houston, Denise , Jacques, Paul , Kanoni, Stavroula , Lehtimäki, Terho , Lemaitre, Rozenn , Manichaikul, Ani , North, Kari , Ntalla, Ioanna , Sonestedt, Emily , Tanaka, Toshiko , van Rooij, Frank , Bandinelli, Stefania , Djoussé, Luc , Grigoriou, Efi , Johansson, Ingegerd , Lohman, Kurt , Pankow, James , Raitakari, Olli , Riserus, Ulf , Yannakoulia, Mary , Zillikens, M , Hassanali, Neelam , Liu, Yongmei , Mozaffarian, Dariush , Papoutsakis, Constantina , Syvänen, Ann-Christine , Uitterlinden, André , Viikari, Jorma , Groves, Christopher , Hofman, Albert , Lind, Lars , Mccarthy, Mark , Mikkilä, Vera , Mukamal, Kenneth , Franco, Oscar , Borecki, Ingrid , Cupples, L , Dedoussis, George , Ferrucci, Luigi , Hu, Frank , Ingelsson, Erik , Kähönen, Mika , Kao, W , Kritchevsky, Stephen , Orho-Melander, Marju , Prokopenko, Inga , Rotter, Jerome , Siscovick, David , Witteman, Jacqueline , Franks, Paul , Meigs, James , Mckeown, Nicola , Nettleton, Jennifer
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00223166 ; E-ISSN: 15416100
Link: http://search.proquest.com/docview/1323173224/?pq-origsite=primo
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title: Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies1-4
format: Article
creator:
  • Hruby, Adela
  • Ngwa, Julius
  • Renström, Frida
  • Wojczynski, Mary
  • Ganna, Andrea
  • Hallmans, Göran
  • Houston, Denise
  • Jacques, Paul
  • Kanoni, Stavroula
  • Lehtimäki, Terho
  • Lemaitre, Rozenn
  • Manichaikul, Ani
  • North, Kari
  • Ntalla, Ioanna
  • Sonestedt, Emily
  • Tanaka, Toshiko
  • van Rooij, Frank
  • Bandinelli, Stefania
  • Djoussé, Luc
  • Grigoriou, Efi
  • Johansson, Ingegerd
  • Lohman, Kurt
  • Pankow, James
  • Raitakari, Olli
  • Riserus, Ulf
  • Yannakoulia, Mary
  • Zillikens, M
  • Hassanali, Neelam
  • Liu, Yongmei
  • Mozaffarian, Dariush
  • Papoutsakis, Constantina
  • Syvänen, Ann-Christine
  • Uitterlinden, André
  • Viikari, Jorma
  • Groves, Christopher
  • Hofman, Albert
  • Lind, Lars
  • Mccarthy, Mark
  • Mikkilä, Vera
  • Mukamal, Kenneth
  • Franco, Oscar
  • Borecki, Ingrid
  • Cupples, L
  • Dedoussis, George
  • Ferrucci, Luigi
  • Hu, Frank
  • Ingelsson, Erik
  • Kähönen, Mika
  • Kao, W
  • Kritchevsky, Stephen
  • Orho-Melander, Marju
  • Prokopenko, Inga
  • Rotter, Jerome
  • Siscovick, David
  • Witteman, Jacqueline
  • Franks, Paul
  • Meigs, James
  • Mckeown, Nicola
  • Nettleton, Jennifer
subjects:
  • Blood Glucose–Genetics
  • Blood Glucose–Metabolism
  • Female–Blood
  • Genetic Loci–Genetics
  • Humans–Administration & Dosage
  • Insulin–Metabolism
  • Insulin–Pharmacology
  • Magnesium–Genetics
  • Magnesium–Administration & Dosage
  • Magnesium–Metabolism
  • Male–Pharmacology
  • Polymorphism, Single Nucleotide–Pharmacology
  • Trpm Cation Channels–Pharmacology
  • Trace Elements–Pharmacology
  • Trace Elements–Pharmacology
  • Trace Elements–Pharmacology
  • Magnesium
  • Insulin Resistance
  • Studies
  • Diabetes
  • Diet
  • Blood Glucose
  • Insulin
  • Trpm Cation Channels
  • Trpm6 Protein, Human
  • Trace Elements
  • Magnesium
ispartof: The Journal of Nutrition, Mar 2013, Vol.143(3), pp.345-53
description: Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesiumintake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI:-0.024,-0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. [PUBLICATION ]
language: eng
source:
identifier: ISSN: 00223166 ; E-ISSN: 15416100
fulltext: fulltext
issn:
  • 00223166
  • 0022-3166
  • 15416100
  • 1541-6100
url: Link


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titleHigher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies1-4
creatorHruby, Adela ; Ngwa, Julius ; Renström, Frida ; Wojczynski, Mary ; Ganna, Andrea ; Hallmans, Göran ; Houston, Denise ; Jacques, Paul ; Kanoni, Stavroula ; Lehtimäki, Terho ; Lemaitre, Rozenn ; Manichaikul, Ani ; North, Kari ; Ntalla, Ioanna ; Sonestedt, Emily ; Tanaka, Toshiko ; van Rooij, Frank ; Bandinelli, Stefania ; Djoussé, Luc ; Grigoriou, Efi ; Johansson, Ingegerd ; Lohman, Kurt ; Pankow, James ; Raitakari, Olli ; Riserus, Ulf ; Yannakoulia, Mary ; Zillikens, M ; Hassanali, Neelam ; Liu, Yongmei ; Mozaffarian, Dariush ; Papoutsakis, Constantina ; Syvänen, Ann-Christine ; Uitterlinden, André ; Viikari, Jorma ; Groves, Christopher ; Hofman, Albert ; Lind, Lars ; Mccarthy, Mark ; Mikkilä, Vera ; Mukamal, Kenneth ; Franco, Oscar ; Borecki, Ingrid ; Cupples, L ; Dedoussis, George ; Ferrucci, Luigi ; Hu, Frank ; Ingelsson, Erik ; Kähönen, Mika ; Kao, W ; Kritchevsky, Stephen ; Orho-Melander, Marju ; Prokopenko, Inga ; Rotter, Jerome ; Siscovick, David ; Witteman, Jacqueline ; Franks, Paul ; Meigs, James ; Mckeown, Nicola ; Nettleton, Jennifer
ispartofThe Journal of Nutrition, Mar 2013, Vol.143(3), pp.345-53
identifierISSN: 00223166 ; E-ISSN: 15416100
subjectBlood Glucose–Genetics ; Blood Glucose–Metabolism ; Female–Blood ; Genetic Loci–Genetics ; Humans–Administration & Dosage ; Insulin–Metabolism ; Insulin–Pharmacology ; Magnesium–Genetics ; Magnesium–Administration & Dosage ; Magnesium–Metabolism ; Male–Pharmacology ; Polymorphism, Single Nucleotide–Pharmacology ; Trpm Cation Channels–Pharmacology ; Trace Elements–Pharmacology ; Trace Elements–Pharmacology ; Trace Elements–Pharmacology ; Magnesium ; Insulin Resistance ; Studies ; Diabetes ; Diet ; Blood Glucose ; Insulin ; Trpm Cation Channels ; Trpm6 Protein, Human ; Trace Elements ; Magnesium
descriptionFavorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesiumintake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI:-0.024,-0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. [PUBLICATION ]
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titleHigher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies1-4
descriptionFavorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesiumintake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI:-0.024,-0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. [PUBLICATION ]
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1Blood Glucose–Metabolism
2Female–Blood
3Genetic Loci–Genetics
4Humans–Administration & Dosage
5Insulin–Metabolism
6Insulin–Pharmacology
7Magnesium–Genetics
8Magnesium–Administration & Dosage
9Magnesium–Metabolism
10Male–Pharmacology
11Polymorphism, Single Nucleotide–Pharmacology
12Trpm Cation Channels–Pharmacology
13Trace Elements–Pharmacology
14Magnesium
15Insulin Resistance
16Studies
17Diabetes
18Diet
19Blood Glucose
20Insulin
21Trpm Cation Channels
22Trpm6 Protein, Human
23Trace Elements
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titleHigher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies1-4
authorHruby, Adela ; Ngwa, Julius ; Renström, Frida ; Wojczynski, Mary ; Ganna, Andrea ; Hallmans, Göran ; Houston, Denise ; Jacques, Paul ; Kanoni, Stavroula ; Lehtimäki, Terho ; Lemaitre, Rozenn ; Manichaikul, Ani ; North, Kari ; Ntalla, Ioanna ; Sonestedt, Emily ; Tanaka, Toshiko ; van Rooij, Frank ; Bandinelli, Stefania ; Djoussé, Luc ; Grigoriou, Efi ; Johansson, Ingegerd ; Lohman, Kurt ; Pankow, James ; Raitakari, Olli ; Riserus, Ulf ; Yannakoulia, Mary ; Zillikens, M ; Hassanali, Neelam ; Liu, Yongmei ; Mozaffarian, Dariush ; Papoutsakis, Constantina ; Syvänen, Ann-Christine ; Uitterlinden, André ; Viikari, Jorma ; Groves, Christopher ; Hofman, Albert ; Lind, Lars ; Mccarthy, Mark ; Mikkilä, Vera ; Mukamal, Kenneth ; Franco, Oscar ; Borecki, Ingrid ; Cupples, L ; Dedoussis, George ; Ferrucci, Luigi ; Hu, Frank ; Ingelsson, Erik ; Kähönen, Mika ; Kao, W ; Kritchevsky, Stephen ; Orho-Melander, Marju ; Prokopenko, Inga ; Rotter, Jerome ; Siscovick, David ; Witteman, Jacqueline ; Franks, Paul ; Meigs, James ; Mckeown, Nicola ; Nettleton, Jennifer
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3Genetic Loci–Genetics
4Humans–Administration & Dosage
5Insulin–Metabolism
6Insulin–Pharmacology
7Magnesium–Genetics
8Magnesium–Administration & Dosage
9Magnesium–Metabolism
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11Polymorphism, Single Nucleotide–Pharmacology
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13Trace Elements–Pharmacology
14Magnesium
15Insulin Resistance
16Studies
17Diabetes
18Diet
19Blood Glucose
20Insulin
21Trpm Cation Channels
22Trpm6 Protein, Human
23Trace Elements
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39Mukamal, Kenneth
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42Cupples, L
43Dedoussis, George
44Ferrucci, Luigi
45Hu, Frank
46Ingelsson, Erik
47Kähönen, Mika
48Kao, W
49Kritchevsky, Stephen
50Orho-Melander, Marju
51Prokopenko, Inga
52Rotter, Jerome
53Siscovick, David
54Witteman, Jacqueline
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57Mckeown, Nicola
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36Mark
37Vera
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6Houston, Denise
7Jacques, Paul
8Kanoni, Stavroula
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55Franks, Paul
56Meigs, James
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58Nettleton, Jennifer
atitleHigher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies1-4
jtitleThe Journal of Nutrition
risdate20130301
volume143
issue3
spage345
epage53
pages345-53
issn00223166
eissn15416100
formatjournal
genrearticle
ristypeJOUR
abstractFavorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesiumintake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI:-0.024,-0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. [PUBLICATION ABSTRACT]
copBethesda
pubAmerican Institute of Nutrition
urlhttp://search.proquest.com/docview/1323173224/
doi10.3945/jn.112.172049
date2013-03-01