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Prognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy.

A prognostic model that predicts overall survival (OS) for metastatic urothelial cancer (MetUC) patients treated with cisplatin-based chemotherapy was developed, validated, and compared with a commonly used Memorial Sloan-Kettering Cancer Center (MSKCC) risk-score model. Data from 7 protocols that e... Full description

Journal Title: Journal of the National Cancer Institute April 3, 2013, Vol.105(7), pp.499-503
Main Author: Apolo, Andrea B
Other Authors: Ostrovnaya, Irina , Halabi, Susan , Iasonos, Alexia , Philips, George K , Rosenberg, Jonathan E , Riches, Jamie , Small, Eric J , Milowsky, Matthew I , Bajorin, Dean F
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1460-2105 ; DOI: 10.1093/jnci/djt015
Link: http://search.proquest.com/docview/1323797253/?pq-origsite=primo
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title: Prognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy.
format: Article
creator:
  • Apolo, Andrea B
  • Ostrovnaya, Irina
  • Halabi, Susan
  • Iasonos, Alexia
  • Philips, George K
  • Rosenberg, Jonathan E
  • Riches, Jamie
  • Small, Eric J
  • Milowsky, Matthew I
  • Bajorin, Dean F
subjects:
  • Aged–Therapeutic Use
  • Analysis of Variance–Drug Therapy
  • Antineoplastic Combined Chemotherapy Protocols–Mortality
  • Carcinoma, Renal Cell–Administration & Dosage
  • Cisplatin–Administration & Dosage
  • Deoxycytidine–Analogs & Derivatives
  • Doxorubicin–Administration & Dosage
  • Female–Administration & Dosage
  • Humans–Drug Therapy
  • Ifosfamide–Mortality
  • Kidney Neoplasms–Administration & Dosage
  • Male–Pathology
  • Middle Aged–Pathology
  • Nomograms–Pathology
  • Paclitaxel–Pathology
  • Predictive Value of Tests–Pathology
  • Prognosis–Pathology
  • Survival Analysis–Pathology
  • Treatment Outcome–Pathology
  • Urothelium–Pathology
  • Deoxycytidine
  • Doxorubicin
  • Gemcitabine
  • Paclitaxel
  • Cisplatin
  • Ifosfamide
ispartof: Journal of the National Cancer Institute, April 3, 2013, Vol.105(7), pp.499-503
description: A prognostic model that predicts overall survival (OS) for metastatic urothelial cancer (MetUC) patients treated with cisplatin-based chemotherapy was developed, validated, and compared with a commonly used Memorial Sloan-Kettering Cancer Center (MSKCC) risk-score model. Data from 7 protocols that enrolled 308 patients with MetUC were pooled. An external multi-institutional dataset was used to validate the model. The primary measurement of predictive discrimination was Harrell's c-index, computed with 95% confidence interval (CI). The final model included four pretreatment variables to predict OS: visceral metastases, albumin, performance status, and hemoglobin. The Harrell's c-index was 0.67 for the four-variable model and 0.64 for the MSKCC risk-score model, with a prediction improvement for OS (the U statistic and its standard deviation were used to calculate the two-sided P = .002). In the validation cohort, the c-indices for the four-variable and the MSKCC risk-score models were 0.63 (95% CI = 0.56 to 0.69) and 0.58 (95% CI = 0.52 to 0.65), respectively, with superiority of the four-variable model compared with the MSKCC risk-score model for OS (the U statistic and its standard deviation were used to calculate the two-sided P = .02). DOI: 10.1093/jnci/djt015
language: eng
source:
identifier: E-ISSN: 1460-2105 ; DOI: 10.1093/jnci/djt015
fulltext: fulltext
issn:
  • 14602105
  • 1460-2105
url: Link


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titlePrognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy.
creatorApolo, Andrea B ; Ostrovnaya, Irina ; Halabi, Susan ; Iasonos, Alexia ; Philips, George K ; Rosenberg, Jonathan E ; Riches, Jamie ; Small, Eric J ; Milowsky, Matthew I ; Bajorin, Dean F
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descriptionA prognostic model that predicts overall survival (OS) for metastatic urothelial cancer (MetUC) patients treated with cisplatin-based chemotherapy was developed, validated, and compared with a commonly used Memorial Sloan-Kettering Cancer Center (MSKCC) risk-score model. Data from 7 protocols that enrolled 308 patients with MetUC were pooled. An external multi-institutional dataset was used to validate the model. The primary measurement of predictive discrimination was Harrell's c-index, computed with 95% confidence interval (CI). The final model included four pretreatment variables to predict OS: visceral metastases, albumin, performance status, and hemoglobin. The Harrell's c-index was 0.67 for the four-variable model and 0.64 for the MSKCC risk-score model, with a prediction improvement for OS (the U statistic and its standard deviation were used to calculate the two-sided P = .002). In the validation cohort, the c-indices for the four-variable and the MSKCC risk-score models were 0.63 (95% CI = 0.56 to 0.69) and 0.58 (95% CI = 0.52 to 0.65), respectively, with superiority of the four-variable model compared with the MSKCC risk-score model for OS (the U statistic and its standard deviation were used to calculate the two-sided P = .02). DOI: 10.1093/jnci/djt015
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titlePrognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy.
authorApolo, Andrea B ; Ostrovnaya, Irina ; Halabi, Susan ; Iasonos, Alexia ; Philips, George K ; Rosenberg, Jonathan E ; Riches, Jamie ; Small, Eric J ; Milowsky, Matthew I ; Bajorin, Dean F
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