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Statistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption

Background Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective To investigate whether MC4R... Full description

Journal Title: PLoS One Dec 2012, Vol.7(12), p.e52344
Main Author: Corella, Dolores
Other Authors: Ortega-Azorín, Carolina , Sorlí, Jose , Covas, M , Carrasco, Paula , Salas-Salvadó, Jordi , Martínez-González, Miguel , Arós, Fernando , Lapetra, José , Serra-Majem, Lluís , Lamuela-Raventos, Rosa , Gómez-Gracia, Enrique , Fiol, Miquel , Pintó, Xavier , Ros, Emilio , Martí, Amelia , Coltell, Oscar , Ordovás, Jose , Estruch, Ramon
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0052344
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title: Statistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption
format: Article
creator:
  • Corella, Dolores
  • Ortega-Azorín, Carolina
  • Sorlí, Jose
  • Covas, M
  • Carrasco, Paula
  • Salas-Salvadó, Jordi
  • Martínez-González, Miguel
  • Arós, Fernando
  • Lapetra, José
  • Serra-Majem, Lluís
  • Lamuela-Raventos, Rosa
  • Gómez-Gracia, Enrique
  • Fiol, Miquel
  • Pintó, Xavier
  • Ros, Emilio
  • Martí, Amelia
  • Coltell, Oscar
  • Ordovás, Jose
  • Estruch, Ramon
subjects:
  • Spain
  • Statistics
  • Food Science
  • Physical Activity
  • Body Mass Index
  • Epidemiology
  • Mutation
  • Nutrition Research
  • Food Intake
  • Biological Effects
  • Obesity
  • Alleles
  • Hospitals
  • Internal Medicine
  • Melanocortin Mc4 Receptors
  • Diet
  • Body Mass Index
  • Consumption
  • Genes
  • Risk
  • Ethanol
  • Health Care
  • Body Mass
  • Cardiovascular Diseases
  • Obesity
  • Alcohol
  • Body Size
  • Obesity
  • Public Health
  • Melanocortin
  • Alcohol
  • Preventive Medicine
  • Obesity
  • Lifestyles
  • Body Fat
  • Health Risks
  • Food Intake
  • Diabetes
  • University of Valencia
  • University of Navarra
  • Alleles
  • Physical Activity
  • Obesity
  • Body Mass Index
  • Alcohol Consumption
  • Diabetes Mellitus
  • Diet
  • Genetic Predisposition
ispartof: PLoS One, Dec 2012, Vol.7(12), p.e52344
description: Background Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Methods Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associations (aggregate genetic score) as well as statistical and biological gene-lifestyle interactions were analyzed. Results FTO rs9939609 was associated with higher body mass index (BMI), waist circumference (WC) and obesity (P
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0052344
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleStatistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption
creatorCorella, Dolores ; Ortega-Azorín, Carolina ; Sorlí, Jose ; Covas, M ; Carrasco, Paula ; Salas-Salvadó, Jordi ; Martínez-González, Miguel ; Arós, Fernando ; Lapetra, José ; Serra-Majem, Lluís ; Lamuela-Raventos, Rosa ; Gómez-Gracia, Enrique ; Fiol, Miquel ; Pintó, Xavier ; Ros, Emilio ; Martí, Amelia ; Coltell, Oscar ; Ordovás, Jose ; Estruch, Ramon
ispartofPLoS One, Dec 2012, Vol.7(12), p.e52344
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0052344
subjectSpain ; Statistics ; Food Science ; Physical Activity ; Body Mass Index ; Epidemiology ; Mutation ; Nutrition Research ; Food Intake ; Biological Effects ; Obesity ; Alleles ; Hospitals ; Internal Medicine ; Melanocortin Mc4 Receptors ; Diet ; Body Mass Index ; Consumption ; Genes ; Risk ; Ethanol ; Health Care ; Body Mass ; Cardiovascular Diseases ; Obesity ; Alcohol ; Body Size ; Obesity ; Public Health ; Melanocortin ; Alcohol ; Preventive Medicine ; Obesity ; Lifestyles ; Body Fat ; Health Risks ; Food Intake ; Diabetes ; University of Valencia ; University of Navarra ; Alleles ; Physical Activity ; Obesity ; Body Mass Index ; Alcohol Consumption ; Diabetes Mellitus ; Diet ; Genetic Predisposition
descriptionBackground Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Methods Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associations (aggregate genetic score) as well as statistical and biological gene-lifestyle interactions were analyzed. Results FTO rs9939609 was associated with higher body mass index (BMI), waist circumference (WC) and obesity (P<0.05 for all). A similar, but not significant trend was found for MC4R rs17782313. Their additive effects (aggregate score) were significant and we observed a 7% per-allele increase of being obese (OR = 1.07; 95%CI 1.01–1.13). We found relevant statistical interactions (P<0.05) with PA. So, in active individuals, the associations with higher BMI, WC or obesity were not detected. A biological (non-statistical) interaction between AdMedDiet and rs9939609 and the aggregate score was found. Greater AdMedDiet in individuals carrying 4 or 3-risk alleles counterbalanced their genetic predisposition, exhibiting similar BMI (P = 0.502) than individuals with no risk alleles and lower AdMedDiet. They also had lower BMI (P = 0.021) than their counterparts with low AdMedDiet. We did not find any consistent association with energy or macronutrients, but found a novel association between these polymorphisms and lower alcohol consumption in variant-allele carriers (B+/−SE: −0.57+/−0.16 g/d per-score-allele; P = 0.001). Conclusion Statistical and biological interactions with PA and diet modulate the effects of FTO and MC4R polymorphisms on obesity. The novel association with alcohol consumption seems independent of their effects on BMI.
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16Coltell, Oscar
17Ordovás, Jose
18Estruch, Ramon
titleStatistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption
descriptionBackground Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Methods Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associations (aggregate genetic score) as well as statistical and biological gene-lifestyle interactions were analyzed. Results FTO rs9939609 was associated with higher body mass index (BMI), waist circumference (WC) and obesity (P<0.05 for all). A similar, but not significant trend was found for MC4R rs17782313. Their additive effects (aggregate score) were significant and we observed a 7% per-allele increase of being obese (OR = 1.07; 95%CI 1.01–1.13). We found relevant statistical interactions (P<0.05) with PA. So, in active individuals, the associations with higher BMI, WC or obesity were not detected. A biological (non-statistical) interaction between AdMedDiet and rs9939609 and the aggregate score was found. Greater AdMedDiet in individuals carrying 4 or 3-risk alleles counterbalanced their genetic predisposition, exhibiting similar BMI (P = 0.502) than individuals with no risk alleles and lower AdMedDiet. They also had lower BMI (P = 0.021) than their counterparts with low AdMedDiet. We did not find any consistent association with energy or macronutrients, but found a novel association between these polymorphisms and lower alcohol consumption in variant-allele carriers (B+/−SE: −0.57+/−0.16 g/d per-score-allele; P = 0.001). Conclusion Statistical and biological interactions with PA and diet modulate the effects of FTO and MC4R polymorphisms on obesity. The novel association with alcohol consumption seems independent of their effects on BMI.
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citationpf e52344 vol 7 issue 12
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titleStatistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption
authorCorella, Dolores ; Ortega-Azorín, Carolina ; Sorlí, Jose ; Covas, M ; Carrasco, Paula ; Salas-Salvadó, Jordi ; Martínez-González, Miguel ; Arós, Fernando ; Lapetra, José ; Serra-Majem, Lluís ; Lamuela-Raventos, Rosa ; Gómez-Gracia, Enrique ; Fiol, Miquel ; Pintó, Xavier ; Ros, Emilio ; Martí, Amelia ; Coltell, Oscar ; Ordovás, Jose ; Estruch, Ramon
creationdate20121201
lso0120121201
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0Spain
1Statistics
2Food Science
3Physical Activity
4Body Mass Index
5Epidemiology
6Mutation
7Nutrition Research
8Food Intake
9Biological Effects
10Obesity
11Alleles
12Hospitals
13Internal Medicine
14Melanocortin Mc4 Receptors
15Diet
16Consumption
17Genes
18Risk
19Ethanol
20Health Care
21Body Mass
22Cardiovascular Diseases
23Alcohol
24Body Size
25Public Health
26Melanocortin
27Preventive Medicine
28Lifestyles
29Body Fat
30Health Risks
31Diabetes
32University of Valencia
33University of Navarra
34Alcohol Consumption
35Diabetes Mellitus
36Genetic Predisposition
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15Engineering Database
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atitleStatistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption
jtitlePLoS One
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abstractBackground Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Methods Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associations (aggregate genetic score) as well as statistical and biological gene-lifestyle interactions were analyzed. Results FTO rs9939609 was associated with higher body mass index (BMI), waist circumference (WC) and obesity (P<0.05 for all). A similar, but not significant trend was found for MC4R rs17782313. Their additive effects (aggregate score) were significant and we observed a 7% per-allele increase of being obese (OR = 1.07; 95%CI 1.01–1.13). We found relevant statistical interactions (P<0.05) with PA. So, in active individuals, the associations with higher BMI, WC or obesity were not detected. A biological (non-statistical) interaction between AdMedDiet and rs9939609 and the aggregate score was found. Greater AdMedDiet in individuals carrying 4 or 3-risk alleles counterbalanced their genetic predisposition, exhibiting similar BMI (P = 0.502) than individuals with no risk alleles and lower AdMedDiet. They also had lower BMI (P = 0.021) than their counterparts with low AdMedDiet. We did not find any consistent association with energy or macronutrients, but found a novel association between these polymorphisms and lower alcohol consumption in variant-allele carriers (B+/−SE: −0.57+/−0.16 g/d per-score-allele; P = 0.001). Conclusion Statistical and biological interactions with PA and diet modulate the effects of FTO and MC4R polymorphisms on obesity. The novel association with alcohol consumption seems independent of their effects on BMI.
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pubPublic Library of Science
doi10.1371/journal.pone.0052344
urlhttp://search.proquest.com/docview/1327146358/
pagese52344
oafree_for_read
date2012-12-01