schliessen

Filtern

 

Bibliotheken

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Obesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and gut barrier disruption. Microbial composition and the mechanisms of interaction with the host that affect gut barrier function during obesity and type 2 diabetes have not been elucidated. We recently isolated... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America May 28, 2013, Vol.110(22), p.9066
Main Author: Everard, Amandine
Other Authors: Belzer, Clara , Geurts, Lucie , Ouwerkerk, Janneke , Druart, Céline , Bindels, Laure , Guiot, Yves , Derrien, Muriel , Muccioli, Giulio , Delzenne, Nathalie , de Vos, Willem , Cani, Patrice
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00278424
Link: http://search.proquest.com/docview/1364611012/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1364611012
title: Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
format: Article
creator:
  • Everard, Amandine
  • Belzer, Clara
  • Geurts, Lucie
  • Ouwerkerk, Janneke
  • Druart, Céline
  • Bindels, Laure
  • Guiot, Yves
  • Derrien, Muriel
  • Muccioli, Giulio
  • Delzenne, Nathalie
  • de Vos, Willem
  • Cani, Patrice
subjects:
  • Cells
  • Tissue
  • Diet
  • Obesity
  • Bacteria
  • Metabolic Disorders
ispartof: Proceedings of the National Academy of Sciences of the United States of America, May 28, 2013, Vol.110(22), p.9066
description: Obesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and gut barrier disruption. Microbial composition and the mechanisms of interaction with the host that affect gut barrier function during obesity and type 2 diabetes have not been elucidated. We recently isolated Akkermansia muciniphila, which is a mucin-degrading bacterium that resides in the mucus layer. The presence of this bacterium inversely correlates with body weight in rodents and humans. However, the precise physiological roles played by this bacterium during obesity and metabolic disorders are unknown. This study demonstrated that the abundance of A. muciniphila decreased in obese and type 2 diabetic mice. We also observed that prebiotic feeding normalized A. muciniphila abundance, which correlated with an improved metabolic profile. In addition, we demonstrated that A. muciniphila treatment reversed high-fat diet-induced metabolic disorders, including fat-mass gain, metabolic endotoxemia, adipose tissue inflammation, and insulin resistance. A. muciniphila administration increased the intestinal levels of endocannabinoids that control inflammation, the gut barrier, and gut peptide secretion. Finally, we demonstrated that all these effects required viable A. muciniphila because treatment with heat-killed cells did not improve the metabolic profile or the mucus layer thickness. In summary, this study provides substantial insight into the intricate mechanisms of bacterial (i.e., A. muciniphila) regulation of the cross-talk between the host and gut microbiota. These results also provide a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders. [PUBLICATION ]
language: eng
source:
identifier: ISSN: 00278424
fulltext: fulltext
issn:
  • 00278424
  • 0027-8424
url: Link


@attributes
ID1035027444
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1364611012
sourceidproquest
recordidTN_proquest1364611012
sourcesystemOther
pqid1364611012
galeid334378407
display
typearticle
titleCross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
creatorEverard, Amandine ; Belzer, Clara ; Geurts, Lucie ; Ouwerkerk, Janneke ; Druart, Céline ; Bindels, Laure ; Guiot, Yves ; Derrien, Muriel ; Muccioli, Giulio ; Delzenne, Nathalie ; de Vos, Willem ; Cani, Patrice
ispartofProceedings of the National Academy of Sciences of the United States of America, May 28, 2013, Vol.110(22), p.9066
identifierISSN: 00278424
subjectCells ; Tissue ; Diet ; Obesity ; Bacteria ; Metabolic Disorders
descriptionObesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and gut barrier disruption. Microbial composition and the mechanisms of interaction with the host that affect gut barrier function during obesity and type 2 diabetes have not been elucidated. We recently isolated Akkermansia muciniphila, which is a mucin-degrading bacterium that resides in the mucus layer. The presence of this bacterium inversely correlates with body weight in rodents and humans. However, the precise physiological roles played by this bacterium during obesity and metabolic disorders are unknown. This study demonstrated that the abundance of A. muciniphila decreased in obese and type 2 diabetic mice. We also observed that prebiotic feeding normalized A. muciniphila abundance, which correlated with an improved metabolic profile. In addition, we demonstrated that A. muciniphila treatment reversed high-fat diet-induced metabolic disorders, including fat-mass gain, metabolic endotoxemia, adipose tissue inflammation, and insulin resistance. A. muciniphila administration increased the intestinal levels of endocannabinoids that control inflammation, the gut barrier, and gut peptide secretion. Finally, we demonstrated that all these effects required viable A. muciniphila because treatment with heat-killed cells did not improve the metabolic profile or the mucus layer thickness. In summary, this study provides substantial insight into the intricate mechanisms of bacterial (i.e., A. muciniphila) regulation of the cross-talk between the host and gut microbiota. These results also provide a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders. [PUBLICATION ]
languageeng
source
version10
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1364611012/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Everard, Amandine
1Belzer, Clara
2Geurts, Lucie
3Ouwerkerk, Janneke
4Druart, Céline
5Bindels, Laure
6Guiot, Yves
7Derrien, Muriel
8Muccioli, Giulio
9Delzenne, Nathalie
10de Vos, Willem
11Cani, Patrice
titleCross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
descriptionObesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and gut barrier disruption. Microbial composition and the mechanisms of interaction with the host that affect gut barrier function during obesity and type 2 diabetes have not been elucidated. We recently isolated Akkermansia muciniphila, which is a mucin-degrading bacterium that resides in the mucus layer. The presence of this bacterium inversely correlates with body weight in rodents and humans. However, the precise physiological roles played by this bacterium during obesity and metabolic disorders are unknown. This study demonstrated that the abundance of A. muciniphila decreased in obese and type 2 diabetic mice. We also observed that prebiotic feeding normalized A. muciniphila abundance, which correlated with an improved metabolic profile. In addition, we demonstrated that A. muciniphila treatment reversed high-fat diet-induced metabolic disorders, including fat-mass gain, metabolic endotoxemia, adipose tissue inflammation, and insulin resistance. A. muciniphila administration increased the intestinal levels of endocannabinoids that control inflammation, the gut barrier, and gut peptide secretion. Finally, we demonstrated that all these effects required viable A. muciniphila because treatment with heat-killed cells did not improve the metabolic profile or the mucus layer thickness. In summary, this study provides substantial insight into the intricate mechanisms of bacterial (i.e., A. muciniphila) regulation of the cross-talk between the host and gut microbiota. These results also provide a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders. [PUBLICATION ]
subject
0Cells
1Tissue
2Diet
3Obesity
4Bacteria
5Metabolic Disorders
general
0English
1National Academy of Sciences
2ProQuest Science Journals
3Science Database (Alumni edition)
4ProQuest Agriculture Journals
5Ecology Abstracts
6Entomology Abstracts
7Animal Behavior Abstracts
8Neurosciences Abstracts
9Aquatic Science Journals
10Biological Science Database
11Research Library China
12Engineering Research Database
13Technology Research Database
14ProQuest Research Library
15ProQuest Discovery
16ProQuest Agricultural Science Collection
17ProQuest Aquatic Science Collection
18ProQuest Atmospheric Science Collection
19ProQuest Biological Science Collection
20ProQuest Central
21ProQuest Earth Science Collection
22ProQuest Engineering Collection
23ProQuest Environmental Science Collection
24ProQuest Natural Science Collection
25ProQuest Technology Collection
26Research Library (Alumni edition)
27ProQuest SciTech Collection
28Agricultural & Environmental Science Database
29Earth, Atmospheric & Aquatic Science Database
30Natural Science Collection
31ProQuest Central (new)
32ProQuest Central K-12
33ProQuest Central Korea
34Research Library Prep
35SciTech Premium Collection
36ProQuest Central Essentials
37ProQuest Central China
sourceidproquest
recordidproquest1364611012
issn
000278424
10027-8424
rsrctypearticle
creationdate2013
addtitleProceedings of the National Academy of Sciences of the United States of America
searchscope
01000283
11005631
21005660
31006072
41006759
51006765
61006993
71007015
81007160
91007385
101007396
111007403
121007420
131007431
141007444
151007447
161007490
171007515
181007531
191007536
201007538
211007552
221007844
231007845
241007849
251007856
261007899
271007902
281007906
291007909
301007945
311008005
321008008
331008886
341009127
351009384
3610000002
3710000004
3810000005
3910000006
4010000013
4110000015
4210000022
4310000025
4410000027
4510000034
4610000035
4710000036
4810000037
4910000038
5010000039
5110000040
5210000041
5310000043
5410000050
5510000053
5610000064
5710000118
5810000120
5910000164
6010000198
6110000200
6210000209
6310000217
6410000234
6510000238
6610000244
6710000253
6810000255
6910000256
7010000257
7110000258
7210000259
7310000260
7410000268
7510000281
7610000300
77proquest
scope
01000283
11005631
21005660
31006072
41006759
51006765
61006993
71007015
81007160
91007385
101007396
111007403
121007420
131007431
141007444
151007447
161007490
171007515
181007531
191007536
201007538
211007552
221007844
231007845
241007849
251007856
261007899
271007902
281007906
291007909
301007945
311008005
321008008
331008886
341009127
351009384
3610000002
3710000004
3810000005
3910000006
4010000013
4110000015
4210000022
4310000025
4410000027
4510000034
4610000035
4710000036
4810000037
4910000038
5010000039
5110000040
5210000041
5310000043
5410000050
5510000053
5610000064
5710000118
5810000120
5910000164
6010000198
6110000200
6210000209
6310000217
6410000234
6510000238
6610000244
6710000253
6810000255
6910000256
7010000257
7110000258
7210000259
7310000260
7410000268
7510000281
7610000300
77proquest
lsr43
01000283false
11005631false
21005660false
31006072false
41006759false
51006765false
61006993false
71007015false
81007160false
91007385false
101007396false
111007403false
121007420false
131007431false
141007444false
151007447false
161007490false
171007515false
181007531false
191007536false
201007538false
211007552false
221007844false
231007845false
241007849false
251007856false
261007899false
271007902false
281007906false
291007909false
301007945false
311008005false
321008008false
331008886false
341009127false
351009384false
3610000002false
3710000004false
3810000005false
3910000006false
4010000013false
4110000015false
4210000022false
4310000025false
4410000027false
4510000034false
4610000035false
4710000036false
4810000037false
4910000038false
5010000039false
5110000040false
5210000041false
5310000043false
5410000050false
5510000053false
5610000064false
5710000118false
5810000120false
5910000164false
6010000198false
6110000200false
6210000209false
6310000217false
6410000234false
6510000238false
6610000244false
6710000253false
6810000255false
6910000256false
7010000257false
7110000258false
7210000259false
7310000260false
7410000268false
7510000281false
7610000300false
startdate20130528
enddate20130528
citationpf 9066 vol 110 issue 22
lsr30VSR-Enriched:[pages, galeid, pqid, doi, eissn]
sort
titleCross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
authorEverard, Amandine ; Belzer, Clara ; Geurts, Lucie ; Ouwerkerk, Janneke ; Druart, Céline ; Bindels, Laure ; Guiot, Yves ; Derrien, Muriel ; Muccioli, Giulio ; Delzenne, Nathalie ; de Vos, Willem ; Cani, Patrice
creationdate20130528
lso0120130528
facets
frbrgroupid4234295918299790777
frbrtype5
languageeng
creationdate2013
topic
0Cells
1Tissue
2Diet
3Obesity
4Bacteria
5Metabolic Disorders
collection
0ProQuest Science Journals
1Science Database (Alumni edition)
2ProQuest Agriculture Journals
3Ecology Abstracts
4Entomology Abstracts
5Animal Behavior Abstracts
6Neurosciences Abstracts
7Aquatic Science Journals
8Biological Science Database
9Research Library China
10Engineering Research Database
11Technology Research Database
12ProQuest Research Library
13ProQuest Discovery
14ProQuest Agricultural Science Collection
15ProQuest Aquatic Science Collection
16ProQuest Atmospheric Science Collection
17ProQuest Biological Science Collection
18ProQuest Central
19ProQuest Earth Science Collection
20ProQuest Engineering Collection
21ProQuest Environmental Science Collection
22ProQuest Natural Science Collection
23ProQuest Technology Collection
24Research Library (Alumni edition)
25ProQuest SciTech Collection
26Agricultural & Environmental Science Database
27Earth, Atmospheric & Aquatic Science Database
28Natural Science Collection
29ProQuest Central (new)
30ProQuest Central K-12
31ProQuest Central Korea
32Research Library Prep
33SciTech Premium Collection
34ProQuest Central Essentials
35ProQuest Central China
prefilterarticles
rsrctypearticles
creatorcontrib
0Everard, Amandine
1Belzer, Clara
2Geurts, Lucie
3Ouwerkerk, Janneke
4Druart, Céline
5Bindels, Laure
6Guiot, Yves
7Derrien, Muriel
8Muccioli, Giulio
9Delzenne, Nathalie
10de Vos, Willem
11Cani, Patrice
jtitleProceedings of the National Academy of Sciences of the United States of America
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Everard
1Belzer
2Geurts
3Ouwerkerk
4Druart
5Bindels
6Guiot
7Derrien
8Muccioli
9Delzenne
10de Vos
11Cani
aufirst
0Amandine
1Clara
2Lucie
3Janneke
4Céline
5Laure
6Yves
7Muriel
8Giulio
9Nathalie
10Willem
11Patrice
auinit1
0A.
1C.
2L.
3J.
4Y.
5M.
6G.
7N.
8W.
9P.
au
0Everard, Amandine
1Belzer, Clara
2Geurts, Lucie
3Ouwerkerk, Janneke
4Druart, Céline
5Bindels, Laure
6Guiot, Yves
7Derrien, Muriel
8Muccioli, Giulio
9Delzenne, Nathalie
10de Vos, Willem
11Cani, Patrice
atitleCross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
jtitleProceedings of the National Academy of Sciences of the United States of America
risdate20130528
volume110
issue22
spage9066
issn00278424
formatjournal
genrearticle
ristypeJOUR
abstractObesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and gut barrier disruption. Microbial composition and the mechanisms of interaction with the host that affect gut barrier function during obesity and type 2 diabetes have not been elucidated. We recently isolated Akkermansia muciniphila, which is a mucin-degrading bacterium that resides in the mucus layer. The presence of this bacterium inversely correlates with body weight in rodents and humans. However, the precise physiological roles played by this bacterium during obesity and metabolic disorders are unknown. This study demonstrated that the abundance of A. muciniphila decreased in obese and type 2 diabetic mice. We also observed that prebiotic feeding normalized A. muciniphila abundance, which correlated with an improved metabolic profile. In addition, we demonstrated that A. muciniphila treatment reversed high-fat diet-induced metabolic disorders, including fat-mass gain, metabolic endotoxemia, adipose tissue inflammation, and insulin resistance. A. muciniphila administration increased the intestinal levels of endocannabinoids that control inflammation, the gut barrier, and gut peptide secretion. Finally, we demonstrated that all these effects required viable A. muciniphila because treatment with heat-killed cells did not improve the metabolic profile or the mucus layer thickness. In summary, this study provides substantial insight into the intricate mechanisms of bacterial (i.e., A. muciniphila) regulation of the cross-talk between the host and gut microbiota. These results also provide a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders. [PUBLICATION ABSTRACT]
copWashington
pubNational Academy of Sciences
urlhttp://search.proquest.com/docview/1364611012/
pages9066-9071
doi10.1073/pnas.1219451110
eissn10916490
date2013-05-28