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Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.

Polymeric nanoparticles that can stably load anticancer drugs and release them in response to a specific trigger such as glutathione are of great interest in cancer therapy. In the present study, dendrimer-encapsulated gold nanoparticles (DEGNPs) were synthesized and used as carriers of thiolated an... Full description

Journal Title: Journal of the American Chemical Society July 3, 2013, Vol.135(26), pp.9805-9810
Main Author: Wang, Xinyu
Other Authors: Cai, Xiaopan , Hu, Jingjing , Shao, Naimin , Wang, Fei , Zhang, Qiang , Xiao, Jianru , Cheng, Yiyun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja402903h
Link: http://search.proquest.com/docview/1393787419/?pq-origsite=primo
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recordid: proquest1393787419
title: Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.
format: Article
creator:
  • Wang, Xinyu
  • Cai, Xiaopan
  • Hu, Jingjing
  • Shao, Naimin
  • Wang, Fei
  • Zhang, Qiang
  • Xiao, Jianru
  • Cheng, Yiyun
subjects:
  • Antineoplastic Agents–Chemistry
  • Cell Survival–Pharmacology
  • Dendrimers–Drug Effects
  • Dose-Response Relationship, Drug–Chemistry
  • Doxorubicin–Chemistry
  • Drug Carriers–Pharmacology
  • Drug Screening Assays, Antitumor–Chemistry
  • Glutathione–Chemistry
  • Gold–Chemistry
  • Hela Cells–Chemistry
  • Humans–Chemistry
  • Metal Nanoparticles–Chemistry
  • Molecular Structure–Chemistry
  • Structure-Activity Relationship–Chemistry
  • Sulfhydryl Compounds–Chemistry
  • Antineoplastic Agents
  • Dendrimers
  • Drug Carriers
  • Sulfhydryl Compounds
  • Gold
  • Doxorubicin
  • Glutathione
ispartof: Journal of the American Chemical Society, July 3, 2013, Vol.135(26), pp.9805-9810
description: Polymeric nanoparticles that can stably load anticancer drugs and release them in response to a specific trigger such as glutathione are of great interest in cancer therapy. In the present study, dendrimer-encapsulated gold nanoparticles (DEGNPs) were synthesized and used as carriers of thiolated anticancer drugs. Thiol-containing drugs such as captopril and 6-mercaptopurine loaded within DEGNPs showed an "Off-On" release behavior in the presence of thiol-reducing agents such as glutathione and dithiothreitol. Thiolated doxorubicin and cisplatin, loaded within the nanoparticle, showed much reduced cytotoxicity as compared to the free anticancer compounds. The toxicity of drug-loaded DEGNPs can be enhanced by improving the intracellular glutathione. Glutathione-triggered release of thiolated doxorubicin within cancer cells is further confirmed by flow cytometry and confocal laser scan microscopy studies. In addition, DEGNPs showed excellent biocompatibility on several cell lines. This study provides a new insight into biomedical applications of dendrimers and dendrimer-encapsulated nanoparticles.
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja402903h
fulltext: no_fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titleGlutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.
creatorWang, Xinyu ; Cai, Xiaopan ; Hu, Jingjing ; Shao, Naimin ; Wang, Fei ; Zhang, Qiang ; Xiao, Jianru ; Cheng, Yiyun
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subjectAntineoplastic Agents–Chemistry ; Cell Survival–Pharmacology ; Dendrimers–Drug Effects ; Dose-Response Relationship, Drug–Chemistry ; Doxorubicin–Chemistry ; Drug Carriers–Pharmacology ; Drug Screening Assays, Antitumor–Chemistry ; Glutathione–Chemistry ; Gold–Chemistry ; Hela Cells–Chemistry ; Humans–Chemistry ; Metal Nanoparticles–Chemistry ; Molecular Structure–Chemistry ; Structure-Activity Relationship–Chemistry ; Sulfhydryl Compounds–Chemistry ; Antineoplastic Agents ; Dendrimers ; Drug Carriers ; Sulfhydryl Compounds ; Gold ; Doxorubicin ; Glutathione
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descriptionPolymeric nanoparticles that can stably load anticancer drugs and release them in response to a specific trigger such as glutathione are of great interest in cancer therapy. In the present study, dendrimer-encapsulated gold nanoparticles (DEGNPs) were synthesized and used as carriers of thiolated anticancer drugs. Thiol-containing drugs such as captopril and 6-mercaptopurine loaded within DEGNPs showed an "Off-On" release behavior in the presence of thiol-reducing agents such as glutathione and dithiothreitol. Thiolated doxorubicin and cisplatin, loaded within the nanoparticle, showed much reduced cytotoxicity as compared to the free anticancer compounds. The toxicity of drug-loaded DEGNPs can be enhanced by improving the intracellular glutathione. Glutathione-triggered release of thiolated doxorubicin within cancer cells is further confirmed by flow cytometry and confocal laser scan microscopy studies. In addition, DEGNPs showed excellent biocompatibility on several cell lines. This study provides a new insight into biomedical applications of dendrimers and dendrimer-encapsulated nanoparticles.
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titleGlutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.
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