schliessen

Filtern

 

Bibliotheken

Preactivated thiomers for vaginal drug delivery vehicles.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biomaterials.2013.06.021 Byline: Heike E. Friedl, Sarah Dunnhaupt, Claudia Waldner, Andreas Bernkop-Schnurch Abstract: It was the purpose of this study to design and evaluate a chitosan derivative as mucoadhes... Full description

Journal Title: Biomaterials October 2013, Vol.34(32), pp.7811-7818
Main Author: Friedl, Heike E
Other Authors: Dünnhaupt, Sarah , Waldner, Claudia , Bernkop-Schnürch, Andreas
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.06.021
Link: http://search.proquest.com/docview/1418362539/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1418362539
title: Preactivated thiomers for vaginal drug delivery vehicles.
format: Article
creator:
  • Friedl, Heike E
  • Dünnhaupt, Sarah
  • Waldner, Claudia
  • Bernkop-Schnürch, Andreas
subjects:
  • Administration, Intravaginal–Chemistry
  • Chitosan–Methods
  • Drug Delivery Systems–Chemistry
  • Excipients–Chemistry
  • Female–Chemistry
  • Humans–Chemistry
  • Polymers–Drug Effects
  • Rheology–Metabolism
  • Sulfhydryl Compounds–Metabolism
  • Thioglycolates–Metabolism
  • Vagina–Metabolism
  • Viscosity–Metabolism
  • Excipients
  • Polymers
  • Sulfhydryl Compounds
  • Thioglycolates
  • 2-Mercaptoacetate
  • Chitosan
  • Chitosan
  • Mucosal Adhesion
ispartof: Biomaterials, October 2013, Vol.34(32), pp.7811-7818
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biomaterials.2013.06.021 Byline: Heike E. Friedl, Sarah Dunnhaupt, Claudia Waldner, Andreas Bernkop-Schnurch Abstract: It was the purpose of this study to design and evaluate a chitosan derivative as mucoadhesive excipient for vaginal drug delivery systems. The chemical modification of chitosan was achieved by conjugation of thioglycolic acid (TGA) resulting in 1594 [mu]mol thiol groups per gram of polymer followed by the linkage of mercaptonicotinic acid (MNA) to the immobilized thiol groups via disulfide bonding leading to 702 [mu]mol ligand per gram of preactivated polymer. The mucoadhesive properties of these polymers within newly designed vaginal formulations (Chitosan-TGA and Chitosan-TGA-MNA) and commercially available vaginal formulations (Candibene.sup.[R], Daktarin.sup.[R], Dalacin.sup.[R], GynoPevaryl.sup.[R]) were tested over a time period of 24 h via a mucoadhesion test system simulating vaginal conditions, tensile studies and mucus polymer interaction studies via viscosity measurements. Within the vaginal test system simulating vaginal in situ conditions, a 1.5-fold increase in mucoadhesion could be observed for preactivated thiomer formulations after 24 h in comparison to commercially available formulations. Similar results were achieved for tensile studies, as the chitosan-TGA-MNA containing formulation resulted in a 4.9-fold increase in total work of adhesion (TWA) in comparison to Candibene which showed the highest TWA value of all tested commercial formulations. Also in terms of rheology investigations of mucus/formulation mixtures, a 5.8-fold increase in dynamic viscosity for chitosan-TGA-MNA containing mixtures could be observed in comparison to the mucus-free control. In contrast, commercially available formulations achieved a maximum enhancement of 1.9-fold. These outcomes confirm that the newly developed polymer is a promising tool for vaginal drug delivery likely providing a prolonged vaginal residence time due to its comparatively high mucoadhesive properties. Author Affiliation: (a) ThioMatrix GmbH, Research Center Innsbruck, Trientlgasse 65, 6020 Innsbruck, Austria (b) Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria Article History: Received 24 April 2013; Accepted 12 June 2013
language: eng
source:
identifier: E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.06.021
fulltext: fulltext
issn:
  • 18785905
  • 1878-5905
url: Link


@attributes
ID450586462
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1418362539
sourceidproquest
recordidTN_proquest1418362539
sourcesystemPC
pqid1418362539
galeid340267944
display
typearticle
titlePreactivated thiomers for vaginal drug delivery vehicles.
creatorFriedl, Heike E ; Dünnhaupt, Sarah ; Waldner, Claudia ; Bernkop-Schnürch, Andreas
contributorFriedl, Heike E (correspondence author) ; Friedl, Heike E (record owner)
ispartofBiomaterials, October 2013, Vol.34(32), pp.7811-7818
identifierE-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.06.021
subjectAdministration, Intravaginal–Chemistry ; Chitosan–Methods ; Drug Delivery Systems–Chemistry ; Excipients–Chemistry ; Female–Chemistry ; Humans–Chemistry ; Polymers–Drug Effects ; Rheology–Metabolism ; Sulfhydryl Compounds–Metabolism ; Thioglycolates–Metabolism ; Vagina–Metabolism ; Viscosity–Metabolism ; Excipients ; Polymers ; Sulfhydryl Compounds ; Thioglycolates ; 2-Mercaptoacetate ; Chitosan ; Chitosan ; Mucosal Adhesion
languageeng
source
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biomaterials.2013.06.021 Byline: Heike E. Friedl, Sarah Dunnhaupt, Claudia Waldner, Andreas Bernkop-Schnurch Abstract: It was the purpose of this study to design and evaluate a chitosan derivative as mucoadhesive excipient for vaginal drug delivery systems. The chemical modification of chitosan was achieved by conjugation of thioglycolic acid (TGA) resulting in 1594 [mu]mol thiol groups per gram of polymer followed by the linkage of mercaptonicotinic acid (MNA) to the immobilized thiol groups via disulfide bonding leading to 702 [mu]mol ligand per gram of preactivated polymer. The mucoadhesive properties of these polymers within newly designed vaginal formulations (Chitosan-TGA and Chitosan-TGA-MNA) and commercially available vaginal formulations (Candibene.sup.[R], Daktarin.sup.[R], Dalacin.sup.[R], GynoPevaryl.sup.[R]) were tested over a time period of 24 h via a mucoadhesion test system simulating vaginal conditions, tensile studies and mucus polymer interaction studies via viscosity measurements. Within the vaginal test system simulating vaginal in situ conditions, a 1.5-fold increase in mucoadhesion could be observed for preactivated thiomer formulations after 24 h in comparison to commercially available formulations. Similar results were achieved for tensile studies, as the chitosan-TGA-MNA containing formulation resulted in a 4.9-fold increase in total work of adhesion (TWA) in comparison to Candibene which showed the highest TWA value of all tested commercial formulations. Also in terms of rheology investigations of mucus/formulation mixtures, a 5.8-fold increase in dynamic viscosity for chitosan-TGA-MNA containing mixtures could be observed in comparison to the mucus-free control. In contrast, commercially available formulations achieved a maximum enhancement of 1.9-fold. These outcomes confirm that the newly developed polymer is a promising tool for vaginal drug delivery likely providing a prolonged vaginal residence time due to its comparatively high mucoadhesive properties. Author Affiliation: (a) ThioMatrix GmbH, Research Center Innsbruck, Trientlgasse 65, 6020 Innsbruck, Austria (b) Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria Article History: Received 24 April 2013; Accepted 12 June 2013
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1418362539/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Friedl, Heike E
1Dünnhaupt, Sarah
2Waldner, Claudia
3Bernkop-Schnürch, Andreas
titlePreactivated thiomers for vaginal drug delivery vehicles.
subject
0Administration, Intravaginal–Chemistry
1Chitosan–Methods
2Drug Delivery Systems–Chemistry
3Excipients–Chemistry
4Female–Chemistry
5Humans–Chemistry
6Polymers–Drug Effects
7Rheology–Metabolism
8Sulfhydryl Compounds–Metabolism
9Thioglycolates–Metabolism
10Vagina–Metabolism
11Viscosity–Metabolism
12Excipients
13Polymers
14Sulfhydryl Compounds
15Thioglycolates
162-Mercaptoacetate
17Chitosan
18Mucosal Adhesion
19Mucosal adhesion
20Thiol
21Vaginal drug delivery
general
0English
110.1016/j.biomaterials.2013.06.021
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1418362539
issn
018785905
11878-5905
rsrctypearticle
creationdate2013
addtitleBiomaterials
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorFriedl, Heike E
startdate20131001
enddate20131001
citationpf 7811 pt 7818 vol 34 issue 32
lsr30VSR-Enriched:[date, galeid, pqid, issn, description]
sort
titlePreactivated thiomers for vaginal drug delivery vehicles.
authorFriedl, Heike E ; Dünnhaupt, Sarah ; Waldner, Claudia ; Bernkop-Schnürch, Andreas
creationdate20131001
lso0120131001
facets
frbrgroupid-3466555648040872368
frbrtype5
newrecords20181218
languageeng
creationdate2013
topic
0Administration, Intravaginal–Chemistry
1Chitosan–Methods
2Drug Delivery Systems–Chemistry
3Excipients–Chemistry
4Female–Chemistry
5Humans–Chemistry
6Polymers–Drug Effects
7Rheology–Metabolism
8Sulfhydryl Compounds–Metabolism
9Thioglycolates–Metabolism
10Vagina–Metabolism
11Viscosity–Metabolism
12Excipients
13Polymers
14Sulfhydryl Compounds
15Thioglycolates
162-Mercaptoacetate
17Chitosan
18Mucosal Adhesion
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Friedl, Heike E
1Dünnhaupt, Sarah
2Waldner, Claudia
3Bernkop-Schnürch, Andreas
jtitleBiomaterials
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Friedl
1Dünnhaupt
2Waldner
3Bernkop-Schnürch
aufirst
0Heike E
1Sarah
2Claudia
3Andreas
au
0Friedl, Heike E
1Dünnhaupt, Sarah
2Waldner, Claudia
3Bernkop-Schnürch, Andreas
addauFriedl, Heike E
atitlePreactivated thiomers for vaginal drug delivery vehicles.
jtitleBiomaterials
risdate20131001
volume34
issue32
spage7811
epage7818
pages7811-7818
eissn1878-5905
formatjournal
genrearticle
ristypeJOUR
doi10.1016/j.biomaterials.2013.06.021
urlhttp://search.proquest.com/docview/1418362539/
issn01429612
date2013-10