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Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.

BACKGROUNDIncreased intra-hepatic resistance to portal blood flow is the primary factor leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) in the cirrhotic liver might be a potential target to ameliorate portal hypertension. OBJECTIVETo verify the effect... Full description

Journal Title: PloS one 2013, Vol.8(7), p.e69309
Main Author: Gao, Jin-Hang
Other Authors: Wen, Shi-Lei , Yang, Wen-Juan , Lu, Yao-Yao , Tong, Huan , Huang, Zhi-Yin , Liu, Zhang-Xu , Tang, Cheng-Wei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0069309
Link: http://search.proquest.com/docview/1418647427/?pq-origsite=primo
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title: Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.
format: Article
creator:
  • Gao, Jin-Hang
  • Wen, Shi-Lei
  • Yang, Wen-Juan
  • Lu, Yao-Yao
  • Tong, Huan
  • Huang, Zhi-Yin
  • Liu, Zhang-Xu
  • Tang, Cheng-Wei
subjects:
  • Angiogenesis Inhibitors–Pharmacology
  • Animals–Therapeutic Use
  • Celecoxib–Complications
  • Disease Models, Animal–Drug Therapy
  • Hypertension, Portal–Physiopathology
  • Kidney–Drug Effects
  • Liver Cirrhosis–Pathology
  • Male–Physiopathology
  • Neovascularization, Pathologic–Complications
  • Pyrazoles–Drug Therapy
  • Rats–Physiopathology
  • Rats, Sprague-Dawley–Complications
  • Signal Transduction–Drug Therapy
  • Sulfonamides–Physiopathology
  • Thioacetamide–Pharmacology
  • Thioacetamide–Therapeutic Use
  • Thioacetamide–Drug Effects
  • Thioacetamide–Pharmacology
  • Thioacetamide–Therapeutic Use
  • Angiogenesis Inhibitors
ispartof: PloS one, 2013, Vol.8(7), p.e69309
description: BACKGROUNDIncreased intra-hepatic resistance to portal blood flow is the primary factor leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) in the cirrhotic liver might be a potential target to ameliorate portal hypertension. OBJECTIVETo verify the effect...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0069309
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleCelecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.
creatorGao, Jin-Hang ; Wen, Shi-Lei ; Yang, Wen-Juan ; Lu, Yao-Yao ; Tong, Huan ; Huang, Zhi-Yin ; Liu, Zhang-Xu ; Tang, Cheng-Wei
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ispartofPloS one, 2013, Vol.8(7), p.e69309
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0069309
subjectAngiogenesis Inhibitors–Pharmacology ; Animals–Therapeutic Use ; Celecoxib–Complications ; Disease Models, Animal–Drug Therapy ; Hypertension, Portal–Physiopathology ; Kidney–Drug Effects ; Liver Cirrhosis–Pathology ; Male–Physiopathology ; Neovascularization, Pathologic–Complications ; Pyrazoles–Drug Therapy ; Rats–Physiopathology ; Rats, Sprague-Dawley–Complications ; Signal Transduction–Drug Therapy ; Sulfonamides–Physiopathology ; Thioacetamide–Pharmacology ; Thioacetamide–Therapeutic Use ; Thioacetamide–Drug Effects ; Thioacetamide–Pharmacology ; Thioacetamide–Therapeutic Use ; Angiogenesis Inhibitors
descriptionBACKGROUNDIncreased intra-hepatic resistance to portal blood flow is the primary factor leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) in the cirrhotic liver might be a potential target to ameliorate portal hypertension. OBJECTIVETo verify the effect...
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titleCelecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.
descriptionBACKGROUNDIncreased intra-hepatic resistance to portal blood flow is the primary factor leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) in the cirrhotic liver might be a potential target to ameliorate portal hypertension. OBJECTIVETo verify the effect...
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titleCelecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.
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abstractBACKGROUNDIncreased intra-hepatic resistance to portal blood flow is the primary factor leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) in the cirrhotic liver might be a potential target to ameliorate portal hypertension. OBJECTIVETo verify the effect...
doi10.1371/journal.pone.0069309
urlhttp://search.proquest.com/docview/1418647427/
date2013-01-01