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Human papillomavirus-associated subsequent malignancies among long-term survivors of pediatric and young adult cancers.

Long-term survivors of pediatric and young adult (PAYA) cancers have a high incidence of subsequent neoplasms, but few risk factors other than cancer treatment have been identified. We aimed to describe the burden of human papillomavirus (HPV)-associated malignancies among survivors of PAYA cancers... Full description

Journal Title: PloS one 2013, Vol.8(8), p.e70349
Main Author: Ojha, Rohit P
Other Authors: Tota, Joseph E , Offutt-Powell, Tabatha N , Klosky, James L , Minniear, Timothy D , Jackson, Bradford E , Gurney, James G
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0070349
Link: http://search.proquest.com/docview/1420612107/?pq-origsite=primo
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title: Human papillomavirus-associated subsequent malignancies among long-term survivors of pediatric and young adult cancers.
format: Article
creator:
  • Ojha, Rohit P
  • Tota, Joseph E
  • Offutt-Powell, Tabatha N
  • Klosky, James L
  • Minniear, Timothy D
  • Jackson, Bradford E
  • Gurney, James G
subjects:
  • Adolescent–Epidemiology
  • Adult–Etiology
  • Child–Complications
  • Child, Preschool–Epidemiology
  • Female–Statistics & Numerical Data
  • Humans–Statistics & Numerical Data
  • Infant–Statistics & Numerical Data
  • Infant, Newborn–Statistics & Numerical Data
  • Male–Statistics & Numerical Data
  • Neoplasms–Statistics & Numerical Data
  • Papillomavirus Infections–Statistics & Numerical Data
  • Survivors–Statistics & Numerical Data
ispartof: PloS one, 2013, Vol.8(8), p.e70349
description: Long-term survivors of pediatric and young adult (PAYA) cancers have a high incidence of subsequent neoplasms, but few risk factors other than cancer treatment have been identified. We aimed to describe the burden of human papillomavirus (HPV)-associated malignancies among survivors of PAYA cancers to assess whether HPV infections might be a reasonable area of future etiologic research on subsequent malignancies in this population. We used longitudinal data from 9 population-based registries of the Surveillance, Epidemiology, and End Results program collected between 1973 and 2010 to assemble a cohort of individuals who were diagnosed with any cancer between the ages of 0 and 29 years and survived at least 5 years post-diagnosis. We estimated sex-specific standardized incidence ratios (SIRs) with corresponding 95% confidence limits (CL) of HPV-associated subsequent malignancies (cervical, vaginal, vulvar, penile, anal, tongue, tonsillar, and oropharyngeal). Our study population comprised 64,547 long-term survivors of PAYA cancers diagnosed between 1973 and 2010. Compared with females in the general US population, female PAYA cancer survivors had a 40% relative excess of HPV-associated malignancies overall (SIR = 1.4, 95% CL: 1.2, 1.8). Compared with males in the general US population, male PAYA cancer survivors had a 150% relative excess of HPV-associated malignancies overall (SIR = 2.5, 95% CL: 1.9, 3.4). Our findings suggest an excess of HPV-associated malignancies among PAYA cancer survivors compared with the general US population. We hypothesize that a portion of subsequent malignancies among PAYA cancer survivors may be directly attributable to HPV infection. This hypothesis warrants exploration in future studies.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0070349
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleHuman papillomavirus-associated subsequent malignancies among long-term survivors of pediatric and young adult cancers.
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descriptionLong-term survivors of pediatric and young adult (PAYA) cancers have a high incidence of subsequent neoplasms, but few risk factors other than cancer treatment have been identified. We aimed to describe the burden of human papillomavirus (HPV)-associated malignancies among survivors of PAYA cancers to assess whether HPV infections might be a reasonable area of future etiologic research on subsequent malignancies in this population. We used longitudinal data from 9 population-based registries of the Surveillance, Epidemiology, and End Results program collected between 1973 and 2010 to assemble a cohort of individuals who were diagnosed with any cancer between the ages of 0 and 29 years and survived at least 5 years post-diagnosis. We estimated sex-specific standardized incidence ratios (SIRs) with corresponding 95% confidence limits (CL) of HPV-associated subsequent malignancies (cervical, vaginal, vulvar, penile, anal, tongue, tonsillar, and oropharyngeal). Our study population comprised 64,547 long-term survivors of PAYA cancers diagnosed between 1973 and 2010. Compared with females in the general US population, female PAYA cancer survivors had a 40% relative excess of HPV-associated malignancies overall (SIR = 1.4, 95% CL: 1.2, 1.8). Compared with males in the general US population, male PAYA cancer survivors had a 150% relative excess of HPV-associated malignancies overall (SIR = 2.5, 95% CL: 1.9, 3.4). Our findings suggest an excess of HPV-associated malignancies among PAYA cancer survivors compared with the general US population. We hypothesize that a portion of subsequent malignancies among PAYA cancer survivors may be directly attributable to HPV infection. This hypothesis warrants exploration in future studies.
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