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Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study.

BACKGROUNDDolutegravir (GSK1349572), a once-daily HIV integrase inhibitor, has shown potent antiviral response and a favourable safety profile. We evaluated safety, efficacy, and emergent resistance in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV-1 with at least two-class dr... Full description

Journal Title: Lancet (London England), August 24, 2013, Vol.382(9893), pp.700-708
Main Author: Cahn, Pedro
Other Authors: Pozniak, Anton L , Mingrone, Horacio , Shuldyakov, Andrey , Brites, Carlos , Andrade-Villanueva, Jaime F , Richmond, Gary , Buendia, Carlos Beltran , Fourie, Jan , Ramgopal, Moti , Hagins, Debbie , Felizarta, Franco , Madruga, Jose , Reuter, Tania , Newman, Tamara , Small, Catherine B , Lombaard, John , Grinsztejn, Beatriz , Dorey, David , Underwood, Mark , Griffith, Sandy , Min, Sherene , Cahn, Pedro
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1474-547X ; DOI: 10.1016/S0140-6736(13)61221-0
Link: http://search.proquest.com/docview/1428270487/?pq-origsite=primo
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title: Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study.
format: Article
creator:
  • Cahn, Pedro
  • Pozniak, Anton L
  • Mingrone, Horacio
  • Shuldyakov, Andrey
  • Brites, Carlos
  • Andrade-Villanueva, Jaime F
  • Richmond, Gary
  • Buendia, Carlos Beltran
  • Fourie, Jan
  • Ramgopal, Moti
  • Hagins, Debbie
  • Felizarta, Franco
  • Madruga, Jose
  • Reuter, Tania
  • Newman, Tamara
  • Small, Catherine B
  • Lombaard, John
  • Grinsztejn, Beatriz
  • Dorey, David
  • Underwood, Mark
  • Griffith, Sandy
  • Min, Sherene
  • Cahn, Pedro
subjects:
  • Adult–Drug Therapy
  • Double-Blind Method–Administration & Dosage
  • Drug Administration Schedule–Adverse Effects
  • Drug Resistance, Viral–Administration & Dosage
  • Female–Adverse Effects
  • HIV Infections–Administration & Dosage
  • HIV Integrase Inhibitors–Adverse Effects
  • HIV-1–Metabolism
  • Heterocyclic Compounds, 3-Ring–Metabolism
  • Humans–Metabolism
  • Male–Metabolism
  • Middle Aged–Metabolism
  • Pyrrolidinones–Metabolism
  • RNA, Viral–Metabolism
  • Raltegravir Potassium–Metabolism
  • Treatment Outcome–Metabolism
  • Viral Load–Metabolism
  • Abridged
  • HIV Integrase Inhibitors
  • Heterocyclic Compounds, 3-Ring
  • Pyrrolidinones
  • RNA, Viral
  • Raltegravir Potassium
  • Dolutegravir
ispartof: Lancet (London, England), August 24, 2013, Vol.382(9893), pp.700-708
description: BACKGROUNDDolutegravir (GSK1349572), a once-daily HIV integrase inhibitor, has shown potent antiviral response and a favourable safety profile. We evaluated safety, efficacy, and emergent resistance in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV-1 with at least two-class drug...
language: eng
source:
identifier: E-ISSN: 1474-547X ; DOI: 10.1016/S0140-6736(13)61221-0
fulltext: fulltext
issn:
  • 1474547X
  • 1474-547X
url: Link


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titleDolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study.
creatorCahn, Pedro ; Pozniak, Anton L ; Mingrone, Horacio ; Shuldyakov, Andrey ; Brites, Carlos ; Andrade-Villanueva, Jaime F ; Richmond, Gary ; Buendia, Carlos Beltran ; Fourie, Jan ; Ramgopal, Moti ; Hagins, Debbie ; Felizarta, Franco ; Madruga, Jose ; Reuter, Tania ; Newman, Tamara ; Small, Catherine B ; Lombaard, John ; Grinsztejn, Beatriz ; Dorey, David ; Underwood, Mark ; Griffith, Sandy ; Min, Sherene ; Cahn, Pedro
contributorSaud, Alejandro Elias Afani (correspondence author) ; Ajana, Faïza (record owner) ; Akil, Bisher ; Villanueva, Jaime-Federico Andrade ; Anstead, Gregory M ; Bánhegyi, Dénes ; Barros, Carlos ; Bartczak, Jennifer C ; Belloso, Waldo H ; Buendia, Carlos J Beltran ; Benetucci, Jorge A ; Blick, Gary ; Bloch, Mark ; Martínez, Vicente Boix ; Brar, Indira ; Alves, Carlos Roberto Brites ; Burack, Jeffrey H ; Cahn, Pedro E ; Sánchez, Alfredo Cano ; Caseiro, Marcos M ; Casey, Kathleen K ; Cassetti, Lidia I ; Iglesia, Ma Angeles Castro ; Chernova, Oksana E ; Sala, Bonaventura Clotet ; Clumeck, Nathan ; Conway, Brian ; De Andrade Neto, Jose L ; Gil, Ignacio De Los Santos ; De Truchis, Pierre ; Comerma, Elisabet Deig ; Delfraissy, Jean-Francois ; Den Hollander, Jan G ; Di Perri, Giovanni ; Diaz, Ricardo S ; Duiculescu, Dan ; Elliott, Julian Hedley James ; Eron, Joseph J ; Feinberg, Judith ; Felizarta, Franco Antonio B ; File, Thomas M ; Florence, Eric ; Cid, Juan Flores ; Fourie, Jan ; Galindo, Maria Jose ; Gargalianos-Kakolyris, Panagiotis ; Gathe, Joseph C ; Ghosn, Jade ; Gogos, Charalambos ; García, Juan González ; Hernández-Mora, Miguel Górgolas ; Gori, Andrea ; Goulston, Claudia ; Granados-Reyes, Enrique Rafael ; Grinsztejn, Beatriz G J ; Gulick, Peter G ; Gupta, Samir K ; Hagins, Debbie P ; Hardy, William D ; Hay, Philip ; Henry, William K ; Hicks, Charles B ; Hodder, Sally Lynn ; Horton, James ; Huhn, Gregory ; Jefferson, Thomas T ; Johnson, Marc A ; Johnson, Philip C ; Katlama, Christine ; Kegg, Stephen ; Khafizov, Kamil M ; Khanlou, Homayoon ; Khoo, Saye H ; Kozal, Michael J ; Kozyrev, Oleg A ; Kulagin, Valery V ; Kumar, Princy N ; Lasso, Martin ; Latiff, Gulam ; Lazzarin, Adriano ; Legrand, Jean-Claude ; Lin, Hsi-Hsun ; Lin, Yu-Hui ; Logue, Kenneth J ; Lombaard, Johannes Jurgens ; Lupo, Sergio H ; Madruga, Jose V R ; Masia, M Del Mar ; Mccurdy, Lewis H ; Mcdonald, Cheryl Kay ; Meier, Jeffery L ; Mikhaylov, Eduard V ; Mildvan, Donna ; Mingrone, Horacio ; Molina, Jean-Michel ; Moshkovich, Grigory F ; Mosqueda-Gómez, Juan-Luis ; Moutschen, Michel ; Murphy, Melissa D ; Nagimova, Firaya I ; Nahass, Ronald G ; Newman, Tamara N L ; Newman-Whitlow, Cheryl L ; Nguyen, Thai C ; O'Keefe, James P ; Osiyemi, Olayemi O ; Paparizos, Vassilios ; Parks, David A ; Perez, Carlos ; Pialoux, Gilles ; Piga, Sandro ; Poizot-Martin, Isabelle ; Pokrovsky, Vadim V ; Pronin, Alexander ; Quertainmont, Yann ; Rakhmanova, Aza G ; Ramgopal, Moti N ; Reuter, Tania Q M ; Ribera, Esteban ; Richmond, Gary J ; Robbins, William J ; Baño, Jesús Rodríguez ; Rodriguez, Jorge E ; Rosas-Dossetti, Margarita-Maricela ; Ruane, Peter J ; Rugina, Sorin ; Rusconi, Stefano ; Ryamova, Elena P ; Saag, Michael S ; Samuel, Rafik ; Sandkovsky, Uriel S ; Scarsella, Anthony J ; Schneider, Stefan ; Schrader, Shannon R ; Scribner, Anita R ; Shalit, Peter ; Shuldyakov, Andrey A ; Siraj, Dawd S ; Slim, Jihad ; Sloan, Louis M ; Smaill, Fiona M ; Small, Catherine B ; Sonin, Dmitriy Borisovich ; Streinu-Cercel, Adrian ; Tashima, Karen T ; Tebas, Pablo ; Teicher, Elina ; Tremblay, Cecile ; Tsai, Hung-Chin ; Tupinambas, Unai ; Vanig, Thanes J ; Méndez, Francisco Jesús Vera ; De Miguel, Miguel Ángel Von Wichmann ; Wang, Jen-Hsien ; Ward, Douglas J ; Warner, Daniel A ; Wheeler, David A ; Wilkins, Edmund G ; Wolff, Marcelo J ; Wong, Wing-Wai ; Yazdanpanah, Yazdan ; Yeni, Guy-Patrick ; Zingman, Barry S ; Zingman, Barry S ; Zingman, Barry S
ispartofLancet (London, England), August 24, 2013, Vol.382(9893), pp.700-708
identifierE-ISSN: 1474-547X ; DOI: 10.1016/S0140-6736(13)61221-0
subjectAdult–Drug Therapy ; Double-Blind Method–Administration & Dosage ; Drug Administration Schedule–Adverse Effects ; Drug Resistance, Viral–Administration & Dosage ; Female–Adverse Effects ; HIV Infections–Administration & Dosage ; HIV Integrase Inhibitors–Adverse Effects ; HIV-1–Metabolism ; Heterocyclic Compounds, 3-Ring–Metabolism ; Humans–Metabolism ; Male–Metabolism ; Middle Aged–Metabolism ; Pyrrolidinones–Metabolism ; RNA, Viral–Metabolism ; Raltegravir Potassium–Metabolism ; Treatment Outcome–Metabolism ; Viral Load–Metabolism ; Abridged ; HIV Integrase Inhibitors ; Heterocyclic Compounds, 3-Ring ; Pyrrolidinones ; RNA, Viral ; Raltegravir Potassium ; Dolutegravir
descriptionBACKGROUNDDolutegravir (GSK1349572), a once-daily HIV integrase inhibitor, has shown potent antiviral response and a favourable safety profile. We evaluated safety, efficacy, and emergent resistance in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV-1 with at least two-class drug...
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1Pozniak, Anton L
2Mingrone, Horacio
3Shuldyakov, Andrey
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8Fourie, Jan
9Ramgopal, Moti
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12Madruga, Jose
13Reuter, Tania
14Newman, Tamara
15Small, Catherine B
16Lombaard, John
17Grinsztejn, Beatriz
18Dorey, David
19Underwood, Mark
20Griffith, Sandy
21Min, Sherene
titleDolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study.
descriptionBACKGROUNDDolutegravir (GSK1349572), a once-daily HIV integrase inhibitor, has shown potent antiviral response and a favourable safety profile. We evaluated safety, efficacy, and emergent resistance in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV-1 with at least two-class drug...
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5HIV Infections–Administration & Dosage
6HIV Integrase Inhibitors–Adverse Effects
7HIV-1–Metabolism
8Heterocyclic...
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5Bánhegyi, Dénes
6Barros, Carlos
7Bartczak, Jennifer C
8Belloso, Waldo H
9Buendia, Carlos J Beltran
10Benetucci, Jorge A
11Blick, Gary
12Bloch, Mark
13Martínez, Vicente Boix
14Brar, Indira
15Alves, Carlos Roberto Brites
16Burack, Jeffrey H
17Cahn, Pedro E
18Sánchez, Alfredo Cano
19Caseiro, Marcos M
20Casey, Kathleen K
21Cassetti, Lidia I
22Iglesia, Ma Angeles Castro
23Chernova, Oksana E
24Sala, Bonaventura Clotet
25Clumeck, Nathan
26Conway, Brian
27De Andrade Neto, Jose L
28Gil, Ignacio De Los Santos
29De Truchis, Pierre
30Comerma, Elisabet Deig
31Delfraissy, Jean-Francois
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33Di Perri, Giovanni
34Diaz, Ricardo S
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36Elliott, Julian Hedley James
37Eron, Joseph J
38Feinberg, Judith
39Felizarta, Franco Antonio B
40File, Thomas M
41Florence, Eric
42Cid, Juan Flores
43Fourie, Jan
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100...
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citationpf 700 pt 708 vol 382 issue 9893
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titleDolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study.
authorCahn, Pedro ; Pozniak, Anton L ; Mingrone, Horacio ; Shuldyakov, Andrey ; Brites, Carlos ; Andrade-Villanueva, Jaime F ; Richmond, Gary ; Buendia, Carlos Beltran ; Fourie, Jan ; Ramgopal, Moti ; Hagins, Debbie ; Felizarta, Franco ; Madruga, Jose ; Reuter, Tania ; Newman, Tamara ; Small, Catherine B ;...
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1Double-Blind Method–Administration & Dosage
2Drug Administration Schedule–Adverse Effects
3Drug Resistance, Viral–Administration & Dosage
4Female–Adverse Effects
5HIV Infections–Administration & Dosage
6HIV Integrase Inhibitors–Adverse Effects
7HIV-1–Metabolism
8Heterocyclic...
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3Shuldyakov, Andrey
4Brites, Carlos
5Andrade-Villanueva, Jaime F
6Richmond, Gary
7Buendia, Carlos Beltran
8Fourie, Jan
9Ramgopal, Moti
10Hagins, Debbie
11Felizarta, Franco
12Madruga, Jose
13Reuter, Tania
14Newman, Tamara
15Small, Catherine B
16Lombaard, John
17Grinsztejn, Beatriz
18Dorey, David
19Underwood, Mark
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22Saud, Alejandro Elias Afani
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24Akil, Bisher
25Villanueva, Jaime-Federico Andrade
26Anstead, Gregory M
27Bánhegyi, Dénes
28Barros, Carlos
29Bartczak, Jennifer C
30Belloso, Waldo H
31Buendia, Carlos J Beltran
32Benetucci, Jorge A
33Blick, Gary
34Bloch, Mark
35Martínez, Vicente Boix
36Brar, Indira
37Alves, Carlos Roberto Brites
38Burack, Jeffrey H
39Cahn, Pedro E
40Sánchez, Alfredo Cano
41Caseiro, Marcos M
42Casey, Kathleen K
43Cassetti, Lidia I
44Iglesia, Ma Angeles Castro
45Chernova, Oksana E
46Sala, Bonaventura Clotet
47Clumeck, Nathan
48Conway, Brian
49De Andrade Neto, Jose L
50Gil, Ignacio De Los Santos
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52Comerma, Elisabet Deig
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20Casey, Kathleen K
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22Iglesia, Ma Angeles Castro
23Chernova, Oksana E
24Sala, Bonaventura Clotet
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26Conway, Brian
27De Andrade Neto, Jose L
28Gil, Ignacio De los Santos
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30Comerma, Elisabet Deig
31Delfraissy, Jean-Francois
32Den Hollander, Jan G
33Di Perri, Giovanni
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50Hernández-Mora, Miguel Górgolas
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52Goulston, Claudia
53Granados-Reyes, Enrique Rafael
54Grinsztejn, Beatriz G J
55Gulick, Peter G
56Gupta, Samir K
57Hagins, Debbie P
58Hardy, William D
59Hay, Philip
60Henry, William K
61Hicks, Charles B
62Hodder, Sally Lynn
63Horton, James
64Huhn, Gregory
65Jefferson, Thomas T
66Johnson, Marc A
67Johnson, Philip C
68Katlama, Christine
69Kegg, Stephen
70Khafizov, Kamil M
71Khanlou, Homayoon
72Khoo, Saye H
73Kozal, Michael J
74Kozyrev, Oleg A
75Kulagin, Valery V
76Kumar, Princy N
77Lasso, Martin
78Latiff, Gulam
79Lazzarin, Adriano
80Legrand, Jean-Claude
81Lin, Hsi-Hsun
82Lin, Yu-Hui
83Logue, Kenneth J
84Lombaard, Johannes Jurgens
85Lupo, Sergio H
86Madruga, Jose V R
87Masia, M Del Mar
88McCurdy, Lewis H
89McDonald, Cheryl Kay
90Meier, Jeffery L
91Mikhaylov, Eduard V
92Mildvan, Donna
93Mingrone, Horacio
94Molina, Jean-Michel
95Moshkovich, Grigory F
96Mosqueda-Gómez, Juan-Luis
97Moutschen, Michel
98Murphy, Melissa D
99Nagimova, Firaya I
100...
atitleDolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study.
jtitleLancet (London, England)
risdate20130824
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issue9893
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pages700-708
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abstractBACKGROUNDDolutegravir (GSK1349572), a once-daily HIV integrase inhibitor, has shown potent antiviral response and a favourable safety profile. We evaluated safety, efficacy, and emergent resistance in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV-1 with at least two-class drug...
doi10.1016/S0140-6736(13)61221-0
urlhttp://search.proquest.com/docview/1428270487/
issn01406736
date2013-08-24