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Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform

Aim: The design of novel F3-targeted liposomes with adequate features for systemic administration, to enable efficient intracellular delivery of siRNA toward both cancer and endothelial cells from angiogenic blood vessels. Materials & methods: Cellular association studies were performed by flow cyto... Full description

Journal Title: Nanomedicine Sep 2013, Vol.8(9), pp.1397-413
Main Author: Gomes-Da-Silva, Lígia
Other Authors: Fernández, Yolanda , Abasolo, Ibane , Schwartz, Simo , Ramalho, José , Pedroso De Lima, Maria , Simões, Sérgio , Moreira, João
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.12.174
Link: http://search.proquest.com/docview/1428792484/?pq-origsite=primo
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recordid: proquest1428792484
title: Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform
format: Article
creator:
  • Gomes-Da-Silva, Lígia
  • Fernández, Yolanda
  • Abasolo, Ibane
  • Schwartz, Simo
  • Ramalho, José
  • Pedroso De Lima, Maria
  • Simões, Sérgio
  • Moreira, João
subjects:
  • Animals–Metabolism
  • Cell Line, Tumor–Administration & Dosage
  • Endothelial Cells–Chemistry
  • Flow Cytometry–Administration & Dosage
  • Gene Silencing–Chemistry
  • Gene Transfer Techniques–Genetics
  • Green Fluorescent Proteins–Therapy
  • Liposomes–Administration & Dosage
  • Liposomes–Genetics
  • Mice–Genetics
  • Nanoparticles–Genetics
  • Nanoparticles–Genetics
  • Neoplasms–Genetics
  • Neoplasms–Genetics
  • RNA, Small Interfering–Genetics
  • RNA, Small Interfering–Genetics
  • Liposomes
ispartof: Nanomedicine, Sep 2013, Vol.8(9), pp.1397-413
description: Aim: The design of novel F3-targeted liposomes with adequate features for systemic administration, to enable efficient intracellular delivery of siRNA toward both cancer and endothelial cells from angiogenic blood vessels. Materials & methods: Cellular association studies were performed by flow cytometry....
language: eng
source:
identifier: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.12.174
fulltext: fulltext
issn:
  • 17435889
  • 1743-5889
  • 17486963
  • 1748-6963
url: Link


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titleEfficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform
creatorGomes-Da-Silva, Lígia ; Fernández, Yolanda ; Abasolo, Ibane ; Schwartz, Simo ; Ramalho, José ; Pedroso De Lima, Maria ; Simões, Sérgio ; Moreira, João
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subjectAnimals–Metabolism ; Cell Line, Tumor–Administration & Dosage ; Endothelial Cells–Chemistry ; Flow Cytometry–Administration & Dosage ; Gene Silencing–Chemistry ; Gene Transfer Techniques–Genetics ; Green Fluorescent Proteins–Therapy ; Liposomes–Administration & Dosage ; Liposomes–Genetics ; Mice–Genetics ; Nanoparticles–Genetics ; Nanoparticles–Genetics ; Neoplasms–Genetics ; Neoplasms–Genetics ; RNA, Small Interfering–Genetics ; RNA, Small Interfering–Genetics ; Liposomes
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titleEfficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform
authorGomes-Da-Silva, Lígia ; Fernández, Yolanda ; Abasolo, Ibane ; Schwartz, Simo ; Ramalho, José ; Pedroso De Lima, Maria ; Simões, Sérgio ; Moreira, João
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abstractAim: The design of novel F3-targeted liposomes with adequate features for systemic administration, to enable efficient intracellular delivery of siRNA toward both cancer and endothelial cells from angiogenic blood vessels. Materials & methods: Cellular association studies were performed by flow cytometry....
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pubFuture Medicine Ltd
doi10.2217/nnm.12.174
urlhttp://search.proquest.com/docview/1428792484/
date2013-09-01