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Influence of [beta]-Carboline Produced from Glucose and Tryptophan on Protein Synthesis of Chicken Embryo Myoblasts

  Glycation is non-enzymatic reaction causing dehydrating condensation between carbonyl group of reducing sugars and amino group of proteins. In the case of glucose and tryptophan, this reaction forms Schiff base followed by two different reactions of Amadori rearrangement generating Amadori product... Full description

Journal Title: The Journal of Poultry Science 2012, Vol.49(4), p.300
Main Author: Nishimagi, Ryosuke
Other Authors: Kita, Kazumi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 13467395 ; E-ISSN: 13490486
Link: http://search.proquest.com/docview/1439332147/?pq-origsite=primo
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title: Influence of [beta]-Carboline Produced from Glucose and Tryptophan on Protein Synthesis of Chicken Embryo Myoblasts
format: Article
creator:
  • Nishimagi, Ryosuke
  • Kita, Kazumi
subjects:
  • &Amp
  • Beta
  • -Carboline
  • Glycation
  • Myoblast
  • Protein Synthesis
  • Tryptophan
ispartof: The Journal of Poultry Science, 2012, Vol.49(4), p.300
description:   Glycation is non-enzymatic reaction causing dehydrating condensation between carbonyl group of reducing sugars and amino group of proteins. In the case of glucose and tryptophan, this reaction forms Schiff base followed by two different reactions of Amadori rearrangement generating Amadori product and Pictet-Spengler reaction generating (1R,3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (PHP-THβC). Amadori product undergoes further complex reaction to form advanced glycation end products (AGEs). PHP-THβC is one of β-carbolines consisting of an indole skeleton and various side chains. As chickens are known to be one of hyperglycemic animals, it seems to be accelerated glycation and easily produced PHP-THβC when chickens are given excess dietary tryptophan. However, there are little investigations of physiological role of glycated tryptophan. In this study, therefore, various concentrations of PHP-THβC added into culture medium for chicken embryo myoblasts and protein synthesis was measured to clarify the relation of PHP-THβC to muscle protein synthesis. Protein synthesis of chicken embryo myoblasts was decreased by addition of PHP-THβC in range of physiological concentrations in the culture medium. In conclusion, it was supposed that the elevation of PHP-THβC levels in the serum of hyperglycemic animals would decrease muscle protein synthesis.
language: eng
source:
identifier: ISSN: 13467395 ; E-ISSN: 13490486
fulltext: fulltext
issn:
  • 13467395
  • 1346-7395
  • 13490486
  • 1349-0486
url: Link


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titleInfluence of [beta]-Carboline Produced from Glucose and Tryptophan on Protein Synthesis of Chicken Embryo Myoblasts
creatorNishimagi, Ryosuke ; Kita, Kazumi
ispartofThe Journal of Poultry Science, 2012, Vol.49(4), p.300
identifierISSN: 13467395 ; E-ISSN: 13490486
description  Glycation is non-enzymatic reaction causing dehydrating condensation between carbonyl group of reducing sugars and amino group of proteins. In the case of glucose and tryptophan, this reaction forms Schiff base followed by two different reactions of Amadori rearrangement generating Amadori product and Pictet-Spengler reaction generating (1R,3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (PHP-THβC). Amadori product undergoes further complex reaction to form advanced glycation end products (AGEs). PHP-THβC is one of β-carbolines consisting of an indole skeleton and various side chains. As chickens are known to be one of hyperglycemic animals, it seems to be accelerated glycation and easily produced PHP-THβC when chickens are given excess dietary tryptophan. However, there are little investigations of physiological role of glycated tryptophan. In this study, therefore, various concentrations of PHP-THβC added into culture medium for chicken embryo myoblasts and protein synthesis was measured to clarify the relation of PHP-THβC to muscle protein synthesis. Protein synthesis of chicken embryo myoblasts was decreased by addition of PHP-THβC in range of physiological concentrations in the culture medium. In conclusion, it was supposed that the elevation of PHP-THβC levels in the serum of hyperglycemic animals would decrease muscle protein synthesis.
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description  Glycation is non-enzymatic reaction causing dehydrating condensation between carbonyl group of reducing sugars and amino group of proteins. In the case of glucose and tryptophan, this reaction forms Schiff base followed by two different reactions of Amadori rearrangement generating Amadori product and Pictet-Spengler reaction generating (1R,3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (PHP-THβC). Amadori product undergoes further complex reaction to form advanced glycation end products (AGEs). PHP-THβC is one of β-carbolines consisting of an indole skeleton and various side chains. As chickens are known to be one of hyperglycemic animals, it seems to be accelerated glycation and easily produced PHP-THβC when chickens are given excess dietary tryptophan. However, there are little investigations of physiological role of glycated tryptophan. In this study, therefore, various concentrations of PHP-THβC added into culture medium for chicken embryo myoblasts and protein synthesis was measured to clarify the relation of PHP-THβC to muscle protein synthesis. Protein synthesis of chicken embryo myoblasts was decreased by addition of PHP-THβC in range of physiological concentrations in the culture medium. In conclusion, it was supposed that the elevation of PHP-THβC levels in the serum of hyperglycemic animals would decrease muscle protein synthesis.
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abstract  Glycation is non-enzymatic reaction causing dehydrating condensation between carbonyl group of reducing sugars and amino group of proteins. In the case of glucose and tryptophan, this reaction forms Schiff base followed by two different reactions of Amadori rearrangement generating Amadori product and Pictet-Spengler reaction generating (1R,3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (PHP-THβC). Amadori product undergoes further complex reaction to form advanced glycation end products (AGEs). PHP-THβC is one of β-carbolines consisting of an indole skeleton and various side chains. As chickens are known to be one of hyperglycemic animals, it seems to be accelerated glycation and easily produced PHP-THβC when chickens are given excess dietary tryptophan. However, there are little investigations of physiological role of glycated tryptophan. In this study, therefore, various concentrations of PHP-THβC added into culture medium for chicken embryo myoblasts and protein synthesis was measured to clarify the relation of PHP-THβC to muscle protein synthesis. Protein synthesis of chicken embryo myoblasts was decreased by addition of PHP-THβC in range of physiological concentrations in the culture medium. In conclusion, it was supposed that the elevation of PHP-THβC levels in the serum of hyperglycemic animals would decrease muscle protein synthesis.
copIbaraki
pubJapan Science and Technology Agency
urlhttp://search.proquest.com/docview/1439332147/
doi10.2141/jpsa.011114
pages300-302