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Simulation of upper airway occlusion without and with mandibular advancement in obstructive sleep apnea using fluid-structure interaction.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jbiomech.2013.08.010 Byline: Moyin Zhao, Tracie Barber, Peter A. Cistulli, Kate Sutherland, Gary Rosengarten Abstract: Obstructive Sleep Apnea (OSA) is a common sleep disorder characterized by repetitive colla... Full description

Journal Title: Journal of biomechanics October 18, 2013, Vol.46(15), pp.2586-2592
Main Author: Zhao, Moyin
Other Authors: Barber, Tracie , Cistulli, Peter A , Sutherland, Kate , Rosengarten, Gary
Format: Electronic Article Electronic Article
Language: English
Subjects:
CFD
Fsi
Mas
Mri
OSA
ID: E-ISSN: 1873-2380 ; DOI: 10.1016/j.jbiomech.2013.08.010
Link: http://search.proquest.com/docview/1443385836/?pq-origsite=primo
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title: Simulation of upper airway occlusion without and with mandibular advancement in obstructive sleep apnea using fluid-structure interaction.
format: Article
creator:
  • Zhao, Moyin
  • Barber, Tracie
  • Cistulli, Peter A
  • Sutherland, Kate
  • Rosengarten, Gary
subjects:
  • Air Pressure–Diagnostic Imaging
  • Airway Obstruction–Physiopathology
  • Computer Simulation–Surgery
  • Humans–Diagnostic Imaging
  • Magnetic Resonance Imaging–Physiopathology
  • Male–Diagnostic Imaging
  • Mandibular Advancement–Physiopathology
  • Middle Aged–Surgery
  • Models, Biological–Surgery
  • Oropharynx–Surgery
  • Radiography–Surgery
  • Sleep Apnea, Obstructive–Surgery
  • Airway Occlusion
  • CFD
  • Fsi
  • Mas
  • Mri
  • OSA
  • Upper Airway
ispartof: Journal of biomechanics, October 18, 2013, Vol.46(15), pp.2586-2592
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jbiomech.2013.08.010 Byline: Moyin Zhao, Tracie Barber, Peter A. Cistulli, Kate Sutherland, Gary Rosengarten Abstract: Obstructive Sleep Apnea (OSA) is a common sleep disorder characterized by repetitive collapse of the upper airway (UA). One treatment option is a mandibular advancement splint (MAS) which protrudes the lower jaw, stabilizing the airway. However not all patients respond to MAS therapy and individual effects are not well understood. Simulations of airway behavior may represent a non-invasive means to understand OSA and individual treatment responses. Our aims were (1) to analyze UA occlusion and flow dynamics in OSA using the fluid structure interaction (FSI) method, and (2) to observe changes with MAS. Magnetic resonance imaging (MRI) scans were obtained at baseline and with MAS in a known treatment responder. Computational models of the patients' UA geometry were reconstructed for both conditions. The FSI model demonstrated full collapse of the UA (maximum 5.83mm) pre-treatment (without MAS). The UA collapse was located at the oropharynx with low oropharyngeal pressure (-51.18Pa to -39.08Pa) induced by velopharyngeal jet flow (maximum 10.0m/s). By comparison, simulation results from the UA with MAS, showed smaller deformation (maximum 2.03mm), matching the known clinical response. Our FSI modeling method was validated by physical experiment on a 1:1 flexible UA model fabricated using 3D steriolithography. This is the first study of airflow dynamics in a deformable UA structure and inspiratory flow. These results expand on previous UA models using computational fluid dynamics (CFD), and lay a platform for application of computational models to study biomechanical properties of the UA in the pathogenesis and treatment of OSA. Author Affiliation: (a) School of Mechanical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia (b) Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, and University of Sydney, NSW, Australia (c) NHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS), University of Sydney and Woolcock Institute of Medical Research, Australia (d) School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, VIC 3053, Australia Article History: Accepted 20 August 2013
language: eng
source:
identifier: E-ISSN: 1873-2380 ; DOI: 10.1016/j.jbiomech.2013.08.010
fulltext: fulltext
issn:
  • 18732380
  • 1873-2380
url: Link


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titleSimulation of upper airway occlusion without and with mandibular advancement in obstructive sleep apnea using fluid-structure interaction.
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subjectAir Pressure–Diagnostic Imaging ; Airway Obstruction–Physiopathology ; Computer Simulation–Surgery ; Humans–Diagnostic Imaging ; Magnetic Resonance Imaging–Physiopathology ; Male–Diagnostic Imaging ; Mandibular Advancement–Physiopathology ; Middle Aged–Surgery ; Models, Biological–Surgery ; Oropharynx–Surgery ; Radiography–Surgery ; Sleep Apnea, Obstructive–Surgery ; Airway Occlusion ; CFD ; Fsi ; Mas ; Mri ; OSA ; Upper Airway
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