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Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population.

OBJECTIVETranscription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903... Full description

Journal Title: Diabetes care November 2013, Vol.36(11), pp.3803-3811
Main Author: Corella, Dolores
Other Authors: Carrasco, Paula , Sorlí, Jose V , Estruch, Ramón , Rico-Sanz, Jesús , Martínez-González, Miguel Ángel , Salas-Salvadó, Jordi , Covas, M Isabel , Coltell, Oscar , Arós, Fernando , Lapetra, José , Serra-Majem, Lluís , Ruiz-Gutiérrez, Valentina , Warnberg, Julia , Fiol, Miquel , Pintó, Xavier , Ortega-Azorín, Carolina , Muñoz, Miguel Ángel , Martínez, J Alfredo , Gómez-Gracia, Enrique , González, José I , Ros, Emilio , Ordovás, José M
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Language: English
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ID: E-ISSN: 1935-5548 ; DOI: 1935-5548 ; DOI: 10.2337/dc13-0955
Link: http://search.proquest.com/docview/1445915965/?pq-origsite=primo
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title: Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population.
format: Article
creator:
  • Corella, Dolores
  • Carrasco, Paula
  • Sorlí, Jose V
  • Estruch, Ramón
  • Rico-Sanz, Jesús
  • Martínez-González, Miguel Ángel
  • Salas-Salvadó, Jordi
  • Covas, M Isabel
  • Coltell, Oscar
  • Arós, Fernando
  • Lapetra, José
  • Serra-Majem, Lluís
  • Ruiz-Gutiérrez, Valentina
  • Warnberg, Julia
  • Fiol, Miquel
  • Pintó, Xavier
  • Ortega-Azorín, Carolina
  • Muñoz, Miguel Ángel
  • Martínez, J Alfredo
  • Gómez-Gracia, Enrique
  • González, José I
  • Ros, Emilio
  • Ordovás, José M
subjects:
  • Aged–Epidemiology
  • Cardiovascular Diseases–Prevention & Control
  • Diabetes Mellitus, Type 2–Blood
  • Diet, Mediterranean–Genetics
  • Fasting–Blood
  • Female–Embryology
  • Humans–Prevention & Control
  • Incidence–Genetics
  • Male–Blood
  • Middle Aged–Blood
  • Odds Ratio–Blood
  • Polymorphism, Genetic–Blood
  • Risk Factors–Blood
  • Stroke–Blood
  • Transcription Factor 7-Like 2 Protein–Blood
  • Triglycerides–Blood
  • Transcription Factor 7-Like 2 Protein
  • Triglycerides
ispartof: Diabetes care, November 2013, Vol.36(11), pp.3803-3811
description: OBJECTIVETranscription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet. RESEARCH DESIGN AND METHODSA randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvención con DIetaMEDiterránea study was undertaken and major cardiovascular events assessed. Data were analyzed at baseline and after a median follow-up of 4.8 years. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for cardiovascular events. RESULTSThe TCF7L2-rs7903146 polymorphism was associated with type 2 diabetes (odds ratio 1.87 [95% CI 1.62-2.17] for TT compared with CC). MedDiet interacted significantly with rs7903146 on fasting glucose at baseline (P interaction = 0.004). When adherence to the MedDiet was low, TT had higher fasting glucose concentrations (132.3 ± 3.5 mg/dL) than CC+CT (127.3 ± 3.2 mg/dL) individuals (P = 0.001). Nevertheless, when adherence was high, this increase was not observed (P = 0.605). This modulation was also detected for total cholesterol, LDL cholesterol, and triglycerides (P interaction < 0.05 for all). Likewise, in the randomized trial, TT subjects had a higher stroke incidence in the control group (adjusted HR 2.91 [95% CI 1.36-6.19]; P = 0.006 compared with CC), whereas dietary intervention with MedDiet reduced stroke incidence in TT homozygotes (adjusted HR 0.96 [95% CI 0.49-1.87]; P = 0.892 for TT compared with CC). CONCLUSIONSOur novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence.
language: eng
source:
identifier: E-ISSN: 1935-5548 ; DOI: 1935-5548 ; DOI: 10.2337/dc13-0955
fulltext: fulltext
issn:
  • 19355548
  • 1935-5548
url: Link


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titleMediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population.
creatorCorella, Dolores ; Carrasco, Paula ; Sorlí, Jose V ; Estruch, Ramón ; Rico-Sanz, Jesús ; Martínez-González, Miguel Ángel ; Salas-Salvadó, Jordi ; Covas, M Isabel ; Coltell, Oscar ; Arós, Fernando ; Lapetra, José ; Serra-Majem, Lluís ; Ruiz-Gutiérrez, Valentina ; Warnberg, Julia ; Fiol, Miquel ; Pintó, Xavier ; Ortega-Azorín, Carolina ; Muñoz, Miguel Ángel ; Martínez, J Alfredo ; Gómez-Gracia, Enrique ; González, José I ; Ros, Emilio ; Ordovás, José M
contributorCorella, Dolores (correspondence author) ; Corella, Dolores (record owner)
ispartofDiabetes care, November 2013, Vol.36(11), pp.3803-3811
identifier
subjectAged–Epidemiology ; Cardiovascular Diseases–Prevention & Control ; Diabetes Mellitus, Type 2–Blood ; Diet, Mediterranean–Genetics ; Fasting–Blood ; Female–Embryology ; Humans–Prevention & Control ; Incidence–Genetics ; Male–Blood ; Middle Aged–Blood ; Odds Ratio–Blood ; Polymorphism, Genetic–Blood ; Risk Factors–Blood ; Stroke–Blood ; Transcription Factor 7-Like 2 Protein–Blood ; Triglycerides–Blood ; Transcription Factor 7-Like 2 Protein ; Triglycerides
descriptionOBJECTIVETranscription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet. RESEARCH DESIGN AND METHODSA randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvención con DIetaMEDiterránea study was undertaken and major cardiovascular events assessed. Data were analyzed at baseline and after a median follow-up of 4.8 years. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for cardiovascular events. RESULTSThe TCF7L2-rs7903146 polymorphism was associated with type 2 diabetes (odds ratio 1.87 [95% CI 1.62-2.17] for TT compared with CC). MedDiet interacted significantly with rs7903146 on fasting glucose at baseline (P interaction = 0.004). When adherence to the MedDiet was low, TT had higher fasting glucose concentrations (132.3 ± 3.5 mg/dL) than CC+CT (127.3 ± 3.2 mg/dL) individuals (P = 0.001). Nevertheless, when adherence was high, this increase was not observed (P = 0.605). This modulation was also detected for total cholesterol, LDL cholesterol, and triglycerides (P interaction < 0.05 for all). Likewise, in the randomized trial, TT subjects had a higher stroke incidence in the control group (adjusted HR 2.91 [95% CI 1.36-6.19]; P = 0.006 compared with CC), whereas dietary intervention with MedDiet reduced stroke incidence in TT homozygotes (adjusted HR 0.96 [95% CI 0.49-1.87]; P = 0.892 for TT compared with CC). CONCLUSIONSOur novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence.
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titleMediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population.
descriptionOBJECTIVETranscription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet. RESEARCH DESIGN AND METHODSA randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvención con DIetaMEDiterránea study was undertaken and major cardiovascular events assessed. Data were analyzed at baseline and after a median follow-up of 4.8 years. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for cardiovascular events. RESULTSThe TCF7L2-rs7903146 polymorphism was associated with type 2 diabetes (odds ratio 1.87 [95% CI 1.62-2.17] for TT compared with CC). MedDiet interacted significantly with rs7903146 on fasting glucose at baseline (P interaction = 0.004). When adherence to the MedDiet was low, TT had higher fasting glucose concentrations (132.3 ± 3.5 mg/dL) than CC+CT (127.3 ± 3.2 mg/dL) individuals (P = 0.001). Nevertheless, when adherence was high, this increase was not observed (P = 0.605). This modulation was also detected for total cholesterol, LDL cholesterol, and triglycerides (P interaction < 0.05 for all). Likewise, in the randomized trial, TT subjects had a higher stroke incidence in the control group (adjusted HR 2.91 [95% CI 1.36-6.19]; P = 0.006 compared with CC), whereas dietary intervention with MedDiet reduced stroke incidence in TT homozygotes (adjusted HR 0.96 [95% CI 0.49-1.87]; P = 0.892 for TT compared with CC). CONCLUSIONSOur novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence.
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titleMediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population.
authorCorella, Dolores ; Carrasco, Paula ; Sorlí, Jose V ; Estruch, Ramón ; Rico-Sanz, Jesús ; Martínez-González, Miguel Ángel ; Salas-Salvadó, Jordi ; Covas, M Isabel ; Coltell, Oscar ; Arós, Fernando ; Lapetra, José ; Serra-Majem, Lluís ; Ruiz-Gutiérrez, Valentina ; Warnberg, Julia ; Fiol, Miquel ; Pintó, Xavier ; Ortega-Azorín, Carolina ; Muñoz, Miguel Ángel ; Martínez, J Alfredo ; Gómez-Gracia, Enrique ; González, José I ; Ros, Emilio ; Ordovás, José M
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6Humans–Prevention & Control
7Incidence–Genetics
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9Middle Aged–Blood
10Odds Ratio–Blood
11Polymorphism, Genetic–Blood
12Risk Factors–Blood
13Stroke–Blood
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15Triglycerides–Blood
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16Ortega-Azorín, Carolina
17Muñoz, Miguel Ángel
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abstractOBJECTIVETranscription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet. RESEARCH DESIGN AND METHODSA randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvención con DIetaMEDiterránea study was undertaken and major cardiovascular events assessed. Data were analyzed at baseline and after a median follow-up of 4.8 years. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for cardiovascular events. RESULTSThe TCF7L2-rs7903146 polymorphism was associated with type 2 diabetes (odds ratio 1.87 [95% CI 1.62-2.17] for TT compared with CC). MedDiet interacted significantly with rs7903146 on fasting glucose at baseline (P interaction = 0.004). When adherence to the MedDiet was low, TT had higher fasting glucose concentrations (132.3 ± 3.5 mg/dL) than CC+CT (127.3 ± 3.2 mg/dL) individuals (P = 0.001). Nevertheless, when adherence was high, this increase was not observed (P = 0.605). This modulation was also detected for total cholesterol, LDL cholesterol, and triglycerides (P interaction < 0.05 for all). Likewise, in the randomized trial, TT subjects had a higher stroke incidence in the control group (adjusted HR 2.91 [95% CI 1.36-6.19]; P = 0.006 compared with CC), whereas dietary intervention with MedDiet reduced stroke incidence in TT homozygotes (adjusted HR 0.96 [95% CI 0.49-1.87]; P = 0.892 for TT compared with CC). CONCLUSIONSOur novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence.
doi10.2337/dc13-0955
urlhttp://search.proquest.com/docview/1445915965/
issn01495992
date2013-11-01