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Lipid peroxidation in hemoglobin-containing liposomes. Effects of membrane phospholipid composition and cholesterol content.

The effects of phospholipid-oxidation state and vesicle composition on lipid peroxidation in hemolysate-containing liposomes (hemosomes) were studied by the thiobarbituric acid assay. Liposomes (hemosomes) were prepared from egg phosphatidylcholine (PC) with either low (PC super(0.08)) or high (PC s... Full description

Journal Title: Biochimica et Biophysica Acta: Protein Structure and Molecular Enzymology 1986, Vol.857(2), pp.139-145
Main Author: Szebeni, J
Other Authors: Toth, K
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: © ProQuest LLC All rights reserved
ID: ISSN: 0167-4838
Link: http://search.proquest.com/docview/14460612/
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title: Lipid peroxidation in hemoglobin-containing liposomes. Effects of membrane phospholipid composition and cholesterol content.
format: Article
creator:
  • Szebeni, J
  • Toth, K
subjects:
  • Lipid Peroxidation
  • Hemoglobin
  • Liposomes
  • Phospholipid Composition
  • Cholesterol
  • Containing
  • Content
  • Effects on
  • Cholesterol
  • Containing
  • Content
  • Effects on
  • Hemoglobin
  • Lipid Peroxidation
  • Liposomes
  • Phospholipid Composition
ispartof: Biochimica et Biophysica Acta: Protein Structure and Molecular Enzymology, 1986, Vol.857(2), pp.139-145
description: The effects of phospholipid-oxidation state and vesicle composition on lipid peroxidation in hemolysate-containing liposomes (hemosomes) were studied by the thiobarbituric acid assay. Liposomes (hemosomes) were prepared from egg phosphatidylcholine (PC) with either low (PC super(0.08)) or high (PC super(0.66)) oxidation indices reflecting low and high conjugated diene/lipid hydroperoxy contents. Inclusion of either phosphatidylethanolamine or phosphatidylinositol in the membrane further increased lipid peroxidation in hemosomes prepared from PC super(0.66), whereas phosphatidic acid and phosphatidylserine were inhibitory. The rate of lipid peroxidation showed no correlation with the amount of encapsulated Hb, neither with the oxidation indices nor the polyunsaturated fatty acid contents of negatively charged phospholipids. The findings suggest a possible role for the high cholesterol content and preferential localization of phosphatidylserine in the inner bilayer leaflet of erythrocyte membrane in protecting against Hb-induced lipid peroxidation in the membrane.
language: eng
source: © ProQuest LLC All rights reserved
identifier: ISSN: 0167-4838
fulltext: fulltext
issn:
  • 01674838
  • 0167-4838
url: Link


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titleLipid peroxidation in hemoglobin-containing liposomes. Effects of membrane phospholipid composition and cholesterol content.
creatorSzebeni, J ; Toth, K
contributorSzebeni, J (correspondence author)
ispartofBiochimica et Biophysica Acta: Protein Structure and Molecular Enzymology, 1986, Vol.857(2), pp.139-145
identifierISSN: 0167-4838
subjectLipid Peroxidation ; Hemoglobin ; Liposomes ; Phospholipid Composition ; Cholesterol ; Containing ; Content ; Effects on ; Cholesterol ; Containing ; Content ; Effects on ; Hemoglobin ; Lipid Peroxidation ; Liposomes ; Phospholipid Composition
descriptionThe effects of phospholipid-oxidation state and vesicle composition on lipid peroxidation in hemolysate-containing liposomes (hemosomes) were studied by the thiobarbituric acid assay. Liposomes (hemosomes) were prepared from egg phosphatidylcholine (PC) with either low (PC super(0.08)) or high (PC super(0.66)) oxidation indices reflecting low and high conjugated diene/lipid hydroperoxy contents. Inclusion of either phosphatidylethanolamine or phosphatidylinositol in the membrane further increased lipid peroxidation in hemosomes prepared from PC super(0.66), whereas phosphatidic acid and phosphatidylserine were inhibitory. The rate of lipid peroxidation showed no correlation with the amount of encapsulated Hb, neither with the oxidation indices nor the polyunsaturated fatty acid contents of negatively charged phospholipids. The findings suggest a possible role for the high cholesterol content and preferential localization of phosphatidylserine in the inner bilayer leaflet of erythrocyte membrane in protecting against Hb-induced lipid peroxidation in the membrane.
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titleLipid peroxidation in hemoglobin-containing liposomes. Effects of membrane phospholipid composition and cholesterol content.
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abstractThe effects of phospholipid-oxidation state and vesicle composition on lipid peroxidation in hemolysate-containing liposomes (hemosomes) were studied by the thiobarbituric acid assay. Liposomes (hemosomes) were prepared from egg phosphatidylcholine (PC) with either low (PC super(0.08)) or high (PC super(0.66)) oxidation indices reflecting low and high conjugated diene/lipid hydroperoxy contents. Inclusion of either phosphatidylethanolamine or phosphatidylinositol in the membrane further increased lipid peroxidation in hemosomes prepared from PC super(0.66), whereas phosphatidic acid and phosphatidylserine were inhibitory. The rate of lipid peroxidation showed no correlation with the amount of encapsulated Hb, neither with the oxidation indices nor the polyunsaturated fatty acid contents of negatively charged phospholipids. The findings suggest a possible role for the high cholesterol content and preferential localization of phosphatidylserine in the inner bilayer leaflet of erythrocyte membrane in protecting against Hb-induced lipid peroxidation in the membrane.
urlhttp://search.proquest.com/docview/14460612/
date1986-01-01