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p16^sup INK4a^ protects against dysfunctional telomere-induced ATR-dependent DNA damage responses

Dysfunctional telomeres limit cellular proliferative capacity by activating the p53-p21- and ...-dependent DNA damage responses (DDR). The ... tumor suppressor accumulates in aging tissues, is a biomarker for cellular senescence, and limits stem cell function in vivo. While the activation of a p53-d... Full description

Journal Title: Journal of Clinical Investigation Oct 2013, Vol.123(10), pp.4489-501
Main Author: Wang, Yang
Other Authors: Sharpless, Norman , Chang, Sandy
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: © ProQuest LLC All rights reserved
ID: ISSN: 00219738 ; E-ISSN: 15588238
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recordid: proquest1448809810
title: p16^sup INK4a^ protects against dysfunctional telomere-induced ATR-dependent DNA damage responses
format: Article
creator:
  • Wang, Yang
  • Sharpless, Norman
  • Chang, Sandy
subjects:
  • Aging–Metabolism
  • Animals–Physiology
  • Apoptosis–Metabolism
  • Ataxia Telangiectasia Mutated Proteins–Genetics
  • Bone Marrow Transplantation–Metabolism
  • Cell Proliferation–Physiology
  • Cells, Cultured–Pathology
  • Cyclin-Dependent Kinase Inhibitor P16–Pathology
  • Cyclin-Dependent Kinase Inhibitor P21–Physiology
  • DNA Damage–Metabolism
  • DNA Repair–Metabolism
  • DNA-Binding Proteins–Metabolism
  • DNA-Binding Proteins–Metabolism
  • Female–Metabolism
  • Hematopoiesis–Metabolism
  • Hematopoietic Stem Cells–Metabolism
  • Intestine, Small–Metabolism
  • Male–Metabolism
  • Mice–Metabolism
  • Mice, Scid
ispartof: Journal of Clinical Investigation, Oct 2013, Vol.123(10), pp.4489-501
description: Dysfunctional telomeres limit cellular proliferative capacity by activating the p53-p21- and ...-dependent DNA damage responses (DDR). The ... tumor suppressor accumulates in aging tissues, is a biomarker for cellular senescence, and limits stem cell function in vivo. While the activation of a p53-dependent...
language: eng
source: © ProQuest LLC All rights reserved
identifier: ISSN: 00219738 ; E-ISSN: 15588238
fulltext: fulltext
issn:
  • 00219738
  • 0021-9738
  • 15588238
  • 1558-8238
url: Link


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titlep16^sup INK4a^ protects against dysfunctional telomere-induced ATR-dependent DNA damage responses
creatorWang, Yang ; Sharpless, Norman ; Chang, Sandy
ispartofJournal of Clinical Investigation, Oct 2013, Vol.123(10), pp.4489-501
identifierISSN: 00219738 ; E-ISSN: 15588238
subjectAging–Metabolism ; Animals–Physiology ; Apoptosis–Metabolism ; Ataxia Telangiectasia Mutated Proteins–Genetics ; Bone Marrow Transplantation–Metabolism ; Cell Proliferation–Physiology ; Cells, Cultured–Pathology ; Cyclin-Dependent Kinase Inhibitor P16–Pathology ; Cyclin-Dependent Kinase Inhibitor P21–Physiology ; DNA Damage–Metabolism ; DNA Repair–Metabolism ; DNA-Binding Proteins–Metabolism ; DNA-Binding Proteins–Metabolism ; Female–Metabolism ; Hematopoiesis–Metabolism ; Hematopoietic Stem Cells–Metabolism ; Intestine, Small–Metabolism ; Male–Metabolism ; Mice–Metabolism ; Mice, Scid
descriptionDysfunctional telomeres limit cellular proliferative capacity by activating the p53-p21- and ...-dependent DNA damage responses (DDR). The ... tumor suppressor accumulates in aging tissues, is a biomarker for cellular senescence, and limits stem cell function in vivo. While the activation of a p53-dependent...
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titlep16^sup INK4a^ protects against dysfunctional telomere-induced ATR-dependent DNA damage responses
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abstractDysfunctional telomeres limit cellular proliferative capacity by activating the p53-p21- and ...-dependent DNA damage responses (DDR). The ... tumor suppressor accumulates in aging tissues, is a biomarker for cellular senescence, and limits stem cell function in vivo. While the activation of a p53-dependent...
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pubAmerican Society for Clinical Investigation
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date2013-10-01