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Growth Differentiation Factor-15 Suppresses Maturation and Function of Dendritic Cells and Inhibits Tumor-Specific Immune Response

Dendritic cells (DCs) play a key role in the initiation stage of an antigen-specific immune response. A variety of tumor-derived factors (TDFs) can suppress DC maturation and function, resulting in defects in the tumor-specific immune response. To identify unknown TDFs that may suppress DCs maturati... Full description

Journal Title: PLoS One Nov 2013, Vol.8(11), p.e78618
Main Author: Zhou, Zhizhong
Other Authors: Li, Weina , Yang, Song , Wang, Lili , Zhang, Kuo , Yang, Jing , Zhang, Wei , Su, Haichuan , Zhang, Yingqi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0078618
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title: Growth Differentiation Factor-15 Suppresses Maturation and Function of Dendritic Cells and Inhibits Tumor-Specific Immune Response
format: Article
creator:
  • Zhou, Zhizhong
  • Li, Weina
  • Yang, Song
  • Wang, Lili
  • Zhang, Kuo
  • Yang, Jing
  • Zhang, Wei
  • Su, Haichuan
  • Zhang, Yingqi
subjects:
  • United States–Us
  • China
  • Cancer
  • Prostate
  • Cytotoxicity
  • Liver
  • Hepatoma
  • Cd83 Antigen
  • Immunotherapy
  • Lymphocytes T
  • Immunotherapy
  • Prenatal Development
  • Cytokines
  • Biology
  • Oncology
  • Peptides
  • Interleukin 12
  • Animal Models
  • Kinases
ispartof: PLoS One, Nov 2013, Vol.8(11), p.e78618
description: Dendritic cells (DCs) play a key role in the initiation stage of an antigen-specific immune response. A variety of tumor-derived factors (TDFs) can suppress DC maturation and function, resulting in defects in the tumor-specific immune response. To identify unknown TDFs that may suppress DCs maturation and function, we established a high-throughput screening technology based on a human liver tumor T7 phage cDNA library and screened all of the proteins derived from hepatoma cells that potentially interact with immature DCs. Growth/differentiation factor-15 (GDF-15) was detected and chosen for further study. By incubation of DCs cultures with GDF-15, we demonstrate that GDF-15 can inhibit surface protrusion formation during DC maturation; suppress the membrane expression of CD83, CD86 and HLA-DR on DCs; enhance phagocytosis by DCs; reduce IL-12 and elevate TGF-β1 secretion by DCs; inhibit T cell stimulation and cytotoxic T lymphocyte (CTL) activation by DCs. By building tumor-bearing mouse...
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0078618
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleGrowth Differentiation Factor-15 Suppresses Maturation and Function of Dendritic Cells and Inhibits Tumor-Specific Immune Response
creatorZhou, Zhizhong ; Li, Weina ; Yang, Song ; Wang, Lili ; Zhang, Kuo ; Yang, Jing ; Zhang, Wei ; Su, Haichuan ; Zhang, Yingqi
ispartofPLoS One, Nov 2013, Vol.8(11), p.e78618
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0078618
subjectUnited States–Us ; China ; Cancer ; Prostate ; Cytotoxicity ; Liver ; Hepatoma ; Cd83 Antigen ; Immunotherapy ; Lymphocytes T ; Immunotherapy ; Prenatal Development ; Cytokines ; Biology ; Oncology ; Peptides ; Interleukin 12 ; Animal Models ; Kinases
descriptionDendritic cells (DCs) play a key role in the initiation stage of an antigen-specific immune response. A variety of tumor-derived factors (TDFs) can suppress DC maturation and function, resulting in defects in the tumor-specific immune response. To identify unknown TDFs that may suppress DCs maturation and function, we established a high-throughput screening technology based on a human liver tumor T7 phage cDNA library and screened all of the proteins derived from hepatoma cells that potentially interact with immature DCs. Growth/differentiation factor-15 (GDF-15) was detected and chosen for further study. By incubation of DCs cultures with GDF-15, we demonstrate that GDF-15 can inhibit surface protrusion formation during DC maturation; suppress the membrane expression of CD83, CD86 and HLA-DR on DCs; enhance phagocytosis by DCs; reduce IL-12 and elevate TGF-β1 secretion by DCs; inhibit T cell stimulation and cytotoxic T lymphocyte (CTL) activation by DCs. By building tumor-bearing mouse...
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titleGrowth Differentiation Factor-15 Suppresses Maturation and Function of Dendritic Cells and Inhibits Tumor-Specific Immune Response
descriptionDendritic cells (DCs) play a key role in the initiation stage of an antigen-specific immune response. A variety of tumor-derived factors (TDFs) can suppress DC maturation and function, resulting in defects in the tumor-specific immune response. To identify unknown TDFs that may suppress DCs maturation and function, we established a high-throughput screening technology based on a human liver tumor T7 phage cDNA library and screened all of the proteins derived from hepatoma cells that potentially interact with immature DCs. Growth/differentiation factor-15 (GDF-15) was detected and chosen for further study. By incubation of DCs cultures with GDF-15, we demonstrate that GDF-15 can inhibit surface protrusion formation during DC maturation; suppress the membrane expression of CD83, CD86 and HLA-DR on DCs; enhance phagocytosis by DCs; reduce IL-12 and elevate TGF-β1 secretion by DCs; inhibit T cell stimulation and cytotoxic T lymphocyte (CTL) activation by DCs. By building tumor-bearing mouse...
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citationpf e78618 vol 8 issue 11
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titleGrowth Differentiation Factor-15 Suppresses Maturation and Function of Dendritic Cells and Inhibits Tumor-Specific Immune Response
authorZhou, Zhizhong ; Li, Weina ; Yang, Song ; Wang, Lili ; Zhang, Kuo ; Yang, Jing ; Zhang, Wei ; Su, Haichuan ; Zhang, Yingqi
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abstractDendritic cells (DCs) play a key role in the initiation stage of an antigen-specific immune response. A variety of tumor-derived factors (TDFs) can suppress DC maturation and function, resulting in defects in the tumor-specific immune response. To identify unknown TDFs that may suppress DCs maturation and function, we established a high-throughput screening technology based on a human liver tumor T7 phage cDNA library and screened all of the proteins derived from hepatoma cells that potentially interact with immature DCs. Growth/differentiation factor-15 (GDF-15) was detected and chosen for further study. By incubation of DCs cultures with GDF-15, we demonstrate that GDF-15 can inhibit surface protrusion formation during DC maturation; suppress the membrane expression of CD83, CD86 and HLA-DR on DCs; enhance phagocytosis by DCs; reduce IL-12 and elevate TGF-β1 secretion by DCs; inhibit T cell stimulation and cytotoxic T lymphocyte (CTL) activation by DCs. By building tumor-bearing mouse...
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