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Mediterranean dietary pattern and depression: the PREDIMED randomized trial.

BACKGROUNDA few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studie... Full description

Journal Title: BMC medicine September 20, 2013, Vol.11, p.208
Main Author: Sánchez-Villegas, Almudena
Other Authors: Martínez-González, Miguel Angel , Estruch, Ramón , Salas-Salvadó, Jordi , Corella, Dolores , Covas, Maria Isabel , Arós, Fernando , Romaguera, Dora , Gómez-Gracia, Enrique , Lapetra, José , Pintó, Xavier , Martínez, Jose Alfredo , Lamuela-Raventós, Rosa María , Ros, Emilio , Gea, Alfredo , Wärnberg, Julia , Serra-Majem, Lluis
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1741-7015 ; DOI: 1741-7015 ; DOI: 10.1186/1741-7015-11-208
Link: http://search.proquest.com/docview/1459152508/?pq-origsite=primo
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title: Mediterranean dietary pattern and depression: the PREDIMED randomized trial.
format: Article
creator:
  • Sánchez-Villegas, Almudena
  • Martínez-González, Miguel Angel
  • Estruch, Ramón
  • Salas-Salvadó, Jordi
  • Corella, Dolores
  • Covas, Maria Isabel
  • Arós, Fernando
  • Romaguera, Dora
  • Gómez-Gracia, Enrique
  • Lapetra, José
  • Pintó, Xavier
  • Martínez, Jose Alfredo
  • Lamuela-Raventós, Rosa María
  • Ros, Emilio
  • Gea, Alfredo
  • Wärnberg, Julia
  • Serra-Majem, Lluis
subjects:
  • Aged–Prevention & Control
  • Aged, 80 and Over–Prevention & Control
  • Cardiovascular Diseases–Diet Therapy
  • Depression–Psychology
  • Diabetes Mellitus, Type 2–Epidemiology
  • Diet, Mediterranean–Epidemiology
  • Female–Epidemiology
  • Humans–Epidemiology
  • Male–Epidemiology
  • Middle Aged–Epidemiology
  • Nuts–Epidemiology
  • Olive Oil–Epidemiology
  • Plant Oils–Epidemiology
  • Risk Factors–Epidemiology
  • Spain–Epidemiology
  • Olive Oil
  • Plant Oils
ispartof: BMC medicine, September 20, 2013, Vol.11, p.208
description: BACKGROUNDA few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention. METHODSThis was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevención con Dieta Mediterránea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression. RESULTSWe identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98). CONCLUSIONSThe result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2. TRIAL REGISTRATIONThis trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639.
language: eng
source:
identifier: E-ISSN: 1741-7015 ; DOI: 1741-7015 ; DOI: 10.1186/1741-7015-11-208
fulltext: fulltext
issn:
  • 17417015
  • 1741-7015
url: Link


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titleMediterranean dietary pattern and depression: the PREDIMED randomized trial.
creatorSánchez-Villegas, Almudena ; Martínez-González, Miguel Angel ; Estruch, Ramón ; Salas-Salvadó, Jordi ; Corella, Dolores ; Covas, Maria Isabel ; Arós, Fernando ; Romaguera, Dora ; Gómez-Gracia, Enrique ; Lapetra, José ; Pintó, Xavier ; Martínez, Jose Alfredo ; Lamuela-Raventós, Rosa María ; Ros, Emilio ; Gea, Alfredo ; Wärnberg, Julia ; Serra-Majem, Lluis
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subjectAged–Prevention & Control ; Aged, 80 and Over–Prevention & Control ; Cardiovascular Diseases–Diet Therapy ; Depression–Psychology ; Diabetes Mellitus, Type 2–Epidemiology ; Diet, Mediterranean–Epidemiology ; Female–Epidemiology ; Humans–Epidemiology ; Male–Epidemiology ; Middle Aged–Epidemiology ; Nuts–Epidemiology ; Olive Oil–Epidemiology ; Plant Oils–Epidemiology ; Risk Factors–Epidemiology ; Spain–Epidemiology ; Olive Oil ; Plant Oils
descriptionBACKGROUNDA few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention. METHODSThis was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevención con Dieta Mediterránea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression. RESULTSWe identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98). CONCLUSIONSThe result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2. TRIAL REGISTRATIONThis trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639.
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titleMediterranean dietary pattern and depression: the PREDIMED randomized trial.
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titleMediterranean dietary pattern and depression: the PREDIMED randomized trial.
authorSánchez-Villegas, Almudena ; Martínez-González, Miguel Angel ; Estruch, Ramón ; Salas-Salvadó, Jordi ; Corella, Dolores ; Covas, Maria Isabel ; Arós, Fernando ; Romaguera, Dora ; Gómez-Gracia, Enrique ; Lapetra, José ; Pintó, Xavier ; Martínez, Jose Alfredo ; Lamuela-Raventós, Rosa María ; Ros, Emilio ; Gea, Alfredo ; Wärnberg, Julia ; Serra-Majem, Lluis
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abstractBACKGROUNDA few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention. METHODSThis was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevención con Dieta Mediterránea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression. RESULTSWe identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98). CONCLUSIONSThe result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2. TRIAL REGISTRATIONThis trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639.
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issue1
date2013-09-20